Posted by admin on Dec 25, 2014 in |
Objectives: To determine the incidence, causes, patterns, outcomes and predictors of medication errors (ME) in psychiatric practice. Methodology: A prospective observational study was conducted in the psychiatry department of a tertiary care hospital over a period of 6 months. Patients of either sex and aged ≥ 18 years receiving at least one psychotropic agent were included in the study and analyzed for the ME. The collected data was analyzed for the incidence, causes and patterns of medication errors. Predictors of medication errors were determined using bivariate non parametric analysis. The variables considered to determine predictors were age, gender, length of hospital stay and number of medications. Results: During the study period 215 medication errors were identified from 166 patients and the incidence of medication error was found to be 1.3 per patient. The average number of ME in a patient was 2.1. The most common types of medication errors observed were dose omission (42.12%), wrong technique (11.57%) and wrong administration (10.60%). Factors responsible for medication errors were performance deficit...
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Posted by admin on Dec 25, 2014 in |
ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and acetonitrile (45: 55 v/v) as mobile phase at flow rate of 1.2 mL/min. In this developed method Clopidogrel and Rosuvastatin eluted at a retention time of 4.697 and 3.337 min respectively. The proposed method is having linearity in the concentration range from 10 to 50μg/mL of Clopidogrel and Rosuvastatin. The current method was validated with respect to linearity; precision, lowest limit of detection (LOD), accuracy and recovery according to the USFDA guidelines. The system consisted of a pump (Shimadzu, prominence, UFLC), with 20µl sample injector, along with a PDA detector at a wavelength of 243 nm and 220 nm for Rosuvastatin and Clopidogrel respectively. Data was compiled using Shimadzu LC Solution software. A...
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Posted by admin on Dec 25, 2014 in |
Octenyl succinate derivatives (OSA) of cassava starch having different degree of substitution (DS) were synthesized by microwave irradiation in solid state using a monomode reactor and the drug, theophylline (Thp) was successfully incorporated in the modified starches for getting controlled release properties. The reaction conditions were optimized for maximizing the DS by response surface methodology and it ranged from 0.002 to 0.021, for the different modified starches. Pre-formulation study was done by Fourier transformed infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) for testing the drug-excipient compatibility. Drug incorporated tablets were prepared using the modified starches and their properties were studied. The spectral and DSC studies showed that there was a good compatibility between OSA starch matrix and theophylline. The in vitro drug release study was performed under different conditions of pH and time as well as after storage of the tablets for different time durations. The in vitro release rate was found to be significantly related to the DS of the modified starch and more sustained release of...
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Posted by admin on Dec 25, 2014 in |
A simple, rapid, RP-HPLC method developed for the simultaneous estimation of paracetamol and zaltaprofen in commercial pharmaceutical formulation by applying Derringer’s desirability function. The dependent variables such as Capacity factor of first peak, α value and retention time of tR3 as the responses with three important independent factors of organic phase composition, pH of mobile phase and flow rate, were used to design mathematical models. The experimental responses were fitted into a second order polynomial and the three responses were simultaneously optimized. The optimum assay conditions were: Methanol-Water (pH 3.5 adjusted with 10 % O-phosphoric acid) (60:40 % v/v)as the mobile phase and at a flow rate of 0.98 ml/min. while using this optimum condition, baseline separation with a minimum resolution of 2.0 and a run time of less than 10 min were achieved. This method showed good agreement between the experimental data and predictive value throughout the studied parameter space. The optimized assay condition was validated according to ICH guidelines to confirm specificity, linearity, accuracy and...
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Posted by admin on Dec 25, 2014 in |
Phytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking simulation by phytoestrogen. Docking experiment bring to light that phytoestrogens prevents the binding of oestradiol with its receptor, thereby down regulating the signalling pathway and also acts as inhibitor of enzymes involved in the biosynthesis of endogenous oestradiol. In the present study, thirty phytoestrogen reported from A. racemosus were selected as ligand along with reference compounds using Maestro 9.3. Rutin, shatavarin I, 3, 6, 4′ – trimethoxy-7-O-β-D-glucopyranosyl [1→4]-O-α-D-xylopyranoside glucopyranpsyl, 8-methoxy-5,6,4-trihydroxyisoflavone-7-O-β-D-glucopyranoside,shatavarin X, racemoside A, immunoside showed better interactions with their targets indicated from their respective dock...
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