Posted by admin on Feb 1, 2015 in |
Stoichiometry and apparent stability constant (KC) of the complex formed between Cu(II), hexamine and taurine were determined in water and methanol-water mixtures (% methanol w/w: 3.11; 6.15; 10.4; 15.2; 19.9 and 25.3) by UV–vis spectroscopy at 25o C and constant ionic strength (0.05 M, sodium chloride). Stoichiometry of the ternary complex (1:1: 2, metal: hexamine: taurine) is not modified with an increase in methanol percentage in the analyzed interval. The value of KC in water is greater than in the binary solutions. The effects of changing solvent composition on KC data were explained by linear solvation free energy relationships using the solvatochromic parameter of Kamlet and Taft (α, ß and π*). Multiple linear regression analysis indicates that the hydrogen bond donating ability (α) of the solvent and non-specific interactions (π*) play an important role in the degree of occurrence of the reaction. The effect of temperature on KC was also analyzed by assessing standard entropy and enthalpy variations of the reaction in water. Finally, the structure of the complex...
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Posted by admin on Jan 31, 2015 in |
Depression is a well defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easily annoyed and disinclined to rest. It is a very important public health problem which is devastating millions of life all over world and making the scenario very pathetic. Number of the patients is suffering with psycho-somatic disorders where placebo and psycho therapies work well. Efficacy of placebo on depression due to vague reasons and with vague symptoms is significant and wonderful. It comes through exchange of belief and trust between patient and physician. Placebo response can be vividly observed and measured. Therefore, by applying placebo therapy in genuine cases of aforesaid type of depression, one can be saved from side effects of drugs and un-necessary expenditure as...
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Posted by admin on Jan 31, 2015 in |
This study was performed to determine the anti-ulcer effects of ethanol extract of Parkia speciosa on Indomethacin induced peptic ulcer in Albino rats. Rats of female sex weighing between 150 g – 200 g were used. Rats were divided into six groups with six rats in each group. Omeprazole (20 mg/kg) were used as a standard drug for this study. Parkia speciosa extract were given in three different doses comprised of 100 mg/kg, 200 mg/kg and 400 mg/kg. Pre-treatment were done for 14 days and at the end of the 14th day, rats were kept fasted for 24 hours before administration of Indomethacin at 30 mg/kg. Administration of drugs was done orally. At the end of the study, rats were sacrificed and stomachs were open and stored in 10% formalin solution. The acidity of gastric juice, gastric mucosal lesion and histological changes were studied. Extracts of Parkia speciosa showed a significant (P<0.05) reduction in acidity of gastric juice as compared to the ulcer control group. Two doses of Parkia...
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Posted by admin on Jan 31, 2015 in |
Bacopamonnieri L. Pennell (family: Sclorphulariaceae) is a reputed drug of Ayurveda. The present study was undertaken to investigate the antidepressant activity of alcoholic extract of B. monnieri was studied at doses of 40 mg / kg and 80 mg / kg against TST and FST mice model of depression. Dose dependent reductions in immobility time were observed in TST and FST mice model of depression. The results showed that the alcoholic extract decreased immobility time with the increase swimming time. Ethanolic extract (40, 80 mg / kg, p.o.) (P<0.01) significantly reduced the immobility time by 10 and 15 seconds as compared to the immobility time of control in both the screening models. Imipramine at doses of (20 mg/kg, p.o.,) was selected as reference standard. These results suggested the anti-depression activity of the plant extract. The effect of the extract was 5-20 times less potent than standard imipramine group which was used as a standard. It may be concluded that the alcoholic extract of B. monnieri produces an antidepressant like...
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Posted by admin on Jan 31, 2015 in |
A simple, rapid, and sensitive high-performance liquid chromatographic method with UV detection has been developed and validated according to the ICH guidelines for the quantization of Cefixime (CFXM) and Ofloxacin (OFLO) in tablet preparation. Chromatographic separation was carried out in a Agilent Zorbax Eclipse XDB-C18 column (150 mm × 4.6 mm; 5 μm particle size) of Agilent Technologies with simple mobile phase composition of 25 mM KH2PO4 in water (pH 4.63, maintained by dil Phosphoric acid) and Methanol (65:35, v/v) at a flow rate of 0.5 ml min-1 with injection Volume of 20 µl where detector was set at 288 nm with a total run time of 10 mins. The method was linear over the concentration range of 20-100, μg ml-1 for both of CFXM and OFLO with a correlation coefficient of 0.999 and 0.999 respectively. Limit of quantifications (LOQ) of 5.53, 5.24 and limit of detections (LOD) 1.82, 1.73 μg ml-1 for CFXM and OFLO respectively. Accuracy and precision values of both within-run and between-run obtained from six...
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