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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Dec 1, 2014 in | 0 comments

EVALUATION OF HYDROXYPROPYLMETHYLCELLULOSE (HPMC) HYDROGEL MATRIX FOR DELIVERY OF TRIAMCINOLONE

The main purpose of this study was to evaluate hydrogel matrix systems of hydroxypropylmethylcellulose (HPMC) for oral release of poorly water-soluble drugs, by using triamcinolone (TR) as drug model. The influence of HPMC ratio (%) and compaction force (Kgf) on system performance were studied. Thus, several batches of tablets containing 10 mg of TR were prepared using distinct proportions of HPMC (30, 50 and 60 %; w/w), and characterized by: dimensions, weight, hardness, friability, disintegration time, swelling and dissolution. Regarding the dissolution profiles, several mathematical models were tested and the experimental data were fitted to a zero-order release. Additionally, the correlation between the swelling kinetics and the drug dissolution rate was established, suggesting the importance of the dependency of drug release from the swelling profile for all tested systems. However, there were not improvements for the system containing HPMC ratio higher than 30 % (w/w). To conclude, for the comparative evaluation of the system’s properties, the best technological conditions achieved were for the matrix produced under 7.5 kgf and...

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EFFECT OF Di-n-BUTYL PHTHALATE ON THE EPIDIDYMAL ANTIOXIDANT SYSTEM OF WISTAR RATS

The study evaluates the effect of di-n-butyl phthalate (DBP), a ubiquitous environmental contaminant, on epididymal antioxidant system of Wistar rats. Adult Wistar rats were orally administered DBP (500, 1000 and 1500 mg/ kg b.wt) for 7 days. Body weight increased significantly while caput and cauda epididymal weight decreased. Significant reduction in total protein concentration, lipid soluble antioxidant capacity and vitamin E levels were observed. Water soluble antioxidant activity decreased in caput epididymis at all dose level while it increased significantly in cauda epididymis. A dose dependent increase in lipid peroxidation, lipid hydroperoxides and ascorbic acid levels has been observed. The results  strongly suggests that enhanced lipid peroxidation and lipid hydroperoxides in caput and cauda epididymis is indicative of disruption of membrane fluidity and integrity which may partly be responsible for alteration in total antioxidant capacity and primary defense system-ascorbic acid and vitamin E. In fact, it is an imbalance between the generation and neutralization of reactive oxygen species which leads to epididymal oxidative stress which may be partly responsible...

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GAS CHROMATOGRAPHY AND MASS SPECTROMETRY ANALYSIS OF SOLANUM VILLOSUM (MILL) (SOLANACEAE)

In the present study the bioactive compounds of Solanum villosum leaves extract were used to evaluate by GC – MS method. 50g of fine powder was packed with No.1 Whatman filter paper and placed in soxhlet apparatus along with ethanol. The crude extract were collected and dried at room temperature, 30˚C after which yield was weighed and then performed to GC-MS analysis.  The Ethanol leaf extracts of Solanum villosum to identified Twelve bioactive components such as, Methyl 11,14,17-Eicosatrienoate (29.49%),  4-(3,5-Di-Tert-Butyl-4-Hydroxy Phenyl) Butyl Acrylate (12.04%), N-Hexadecanoic acid (9.41%), Phytol (8.54%),  2H-1-Benzopyran-6-ol, 3,4-Dihydro-2,5,7,8-Tetra methyl-2-(4,8,12-Trimethyl Tridecyl)-Acetate,(2R)-( (5.70%),  DL-Alpha Tocopherol (5.70%), Gamma – Tocopherol (3.55%), 3,4-Dihydro-3,5,8-Trimethyl-3-(4,8,12-Trimethyl Tridecyl)-(2H)1-Benzopyran-6-Acetate (3.55%), 3,7,11,15-Tetramethyl-2-Hexadecen-1-ol (3.38%), Cyclotrisiloxane, Hexamethyl (2.12%),  Trimethyl(4-(1,1,3,3-Tetramethyl butyl)Phenoxy) silane (2.12%), Octasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15- Hexadecamethyl (1.97%) were present.  In best of our knowledge, there is no documental evidence of gas chromatography and mass spectrum analysis to identify the chemical compounds from the plant species of Solanum villosum. This study helps to explore the potential compounds responsible for the biological activities of antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, Diuretic and analgesic...

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SPECTROFLUORIMETRIC STUDIES ON THE INTERACTION OF MOXIFLOXACIN WITH HERRING SPERM DNA

Moxifloxacin (MOX) is a fourth-generation synthetic fluoroquinolone antibacterial agent with many important therapeutic properties.  Fluorescence measurement was used to study the interaction of MOX with herring sperm DNA (Hs-DNA) in Tris-HCl, buffer of pH 7.4.  The intercalative binding mode and a static quenching mechanism were confirmed by the Stern-Volmer quenching rate constant (Kq) of 5.611 x 1013 mol-1 s-1(R2 = 0.99876) at 298 K.  The thermodynamic parameters (ΔH = -133.55 kJ mol–1 and ΔS = -349.98 J mol–1 K–1) were calculated at different temperatures, and they indicate that the main forces between MOX and Hs-DNA are hydrogen bonding and Van der Waals force.  We proved at the same time the presence of one single binding site on Hs-DNA, and the binding constant is 1.48 x 105 M–1 at physiological pH.  The results may provide a basis for further studies and clinical application of antibacterial...

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IN-VITRO ANTIFUNGAL SUSCEPTIBILITY REVEALS OCCURRENCE OF AZOLE AND ALLYLAMINE RESISTANCE AMONG CLINICAL ISOLATES OF CANDIDA ALBICANS AND CANDIDA NON ALBICANS FROM CENTRAL INDIA

Background: Drug resistance among Candida species constitutes the most significant problem in the treatment of Candidiasis.Systematic studies on antifungal drug susceptibility which may be useful in deciding clinical strategies are not routinely done in India and other developing countries. Objective: Aim of this study was testing sensitivity of clinical isolates of Candida albicans and non albicans to frequently prescribe antifungal drugs, fluconazole, ketoconazole, Itraconazole, Amphotericin B and Terbinafine. Material and methods: 25 strains of C. albicans and non albicans were tested in vitro for susceptibility to five antifungal agents, by using standard broth macro dilution method (CLSI M 27-A). Results: The present study revealed the percentage and extent of emerging drug resistance and cross resistance among Central Indian clinical isolates of C. albicans and non albicans against azoles and allylamine.  In the present study, the total percentage of resistance was found to be 84% (21/25). The drug for which maximum resistance were found was Ketoconazole (64%) followed by Itraconazole (44%) Terbinafine (24%) and lastly Fluconazole (20%). The total percentage...

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