Posted by admin on Jan 31, 2015 in |
Adverse drug reactions are undesirable effects of drugs beyond its anticipated therapeutic uses occurring commonly in clinical practice. Although many of these ADRs are mild and disappear when the suspected drug is stopped or dose is reduced, some are more serious and last longer. Many studies have been published regarding hospital admission due to ADRs and it has been estimated that 2.9% to 5.6% of all hospital admissions are due to ADRs and 35% of the hospitalized patients experience an ADR during their hospital stay. Thus ADRs increase not only morbidity and mortality, but also add to the overall healthcare cost. In the present study a total of 1125 patients data were collected from six months study period. Out of 1125, 41 (3.64%) ADRs were identified. From among the 41patients, 22 (53.65%) were males and females were 19 (46.34%). This gender distribution percentage was compared with previous studies. The mean age of our study is 37.95±2.75 years and was compared with the previous similar studies. This study shows the...
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Posted by admin on Jan 31, 2015 in |
The immediate release tablet of antihypertensive drug Valsartan were prepared and evaluated to increase solubility and bioavailability of low soluble drug. The tablets were prepared by direct compression method using Surfactants such as Poloxamer 188, Sodium stearate, Sodium Lauryl Sulfate and Superdisintegrant such as Cross carmellose sodium were used in tablet formulation. The formulation were evaluated for various physical parameters, dissolution study and drug release profile. From all formulations the formulations F-C of batch B 3 i.e SLS-3 showed 98.04% drug release within 30 minutes, which was highest drug release than other batches. The optimized immediate release tablet of batch B 3i.e SLS-3 of formulation F-C showed no change in physical appearance, drug content or in dissolution pattern storage at 40± 20 C / 75 ± 5 % for 90 days. Finally it was concluded that batch B-3 containing formulation F-C i.e. SLS-3 shows highest drug...
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Posted by admin on Jan 31, 2015 in |
A novel method for the simultaneous estimation of Febuxostat and Diclofenac Potassium in combine dosage form was developed and validated by reverse phase high performance liquid chromatography. The determination was performed on an Inertsil C18 column (100mm x 4.6 mm ID, 5µm particle size) and the mobile phase consisting a mixture of 0.01M Ammonium di-hydrogen phosphate buffer (pH adjusted to 5 with orthophosphoric acid) and Acetonitrile (60:40, v/v) was delivered at a flow rate of 1 ml/min and detector wavelength at 287nm. The retention time of Febuxostat and Diclofenac Potassium was found to be 2.303 and 4.105min respectively. The linearity for Febuxostat and Diclofenac Potassium was obtained in the concentration range of 10-60µg/ml and 25-150µg/ml with correlation coefficients (r2) of the regression equations greater than 0.9999 in all cases respectively. Results of assay, accuracy and precision were statistically evaluated as per ICH guidelines. Febuxostat and Diclofenac Potassium were subjected to acid and alkali hydrolysis, thermal and photolytic forced degradation. In the forced degradation study Febuxostat and Diclofenac Potassium showed...
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Posted by admin on Jan 31, 2015 in |
A properly designed system will provide a high degree of assurance that every step, process, and change has been properly evaluated before its implementation. Validation is an important step carried out in order to control the entire process, and the process adapted to produce itself must assure that process will consistently produce the expected results and maintain the desired quality of the final product. Process validation is the validation of each and every step of the processes which involves series of activities carried out in order to have the assurance of the products manufactured. Each and every step should be scientifically planned, conducted and documented appropriately and for this one should have sound knowledge and understanding regarding the process as well as the product. So, the study here shows the research work done on the formulation and process validation of diclofenac sodium and paracetamol combination tablet, the critical process parameters involved in the manufacturing process and the consistency in the results of the three consecutive...
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Posted by admin on Jan 31, 2015 in |
The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities. Highly efficient and simple methods complying with principle of Green chemistry have been described in this manuscript for the synthesis with competent yields. As part of current studies, we here in report economical practical techniques like- microwave synthesis, mortal-pastel method (mechanochemistry) and by application of green solvents. On completion of reaction the products were characterized by IR, NMR and Mass Spectra. These methods are more convenient and reactions can be carried out in higher yield (80-96%), shorter reaction time (3-30 min) and milder conditions, without generation of pollution and safer to...
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