Posted by admin on Dec 1, 2014 in |
This study was conducted as a single blind, randomized and standard controlled clinical trial in cases of Falij Nisfi (Hemiplegia) due to ischaemic stroke. Forty eligible patients of Hemiplegia were randomized into test and control groups, comprising 20 patients in each. Test group was given Nuskha munzije balghamfor12 days, followed byNuskha Mushile Balgham, mixed with Munzije Balgham for next two consecutive days in decoction form, orally. Massage was started from 15th day with Roghan Malkangani on spinal column and paralyzed limbs for 15 minutes daily till 28th day. Control group was given tablet Piracetam Hydrochloride, 800 mg twice a day. Hypertensive patients in both groups, A and B, also received tablet Aspirin, 75 mg and tablet lisinopril, 2.5 mg, once daily for 28 days. The assessment of efficacy was based on “Stroke Rehabilitation Assessment of Movement (STREAM)”. Pre and post treatment values of STREAM were subjected to statistical analysis within and between the groups using Paired‘t’ test, Wilcoxon matched pairs signed rank test, and Kruskal-Wallis test with Dunn’s multiple...
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Posted by admin on Dec 1, 2014 in |
The antidiabetic potential of ethanolic extract of bijasar (Pterocarpus marsupium Roxb.) heartwood was evaluated in the streptozotocin-nicotinamide induced type 2 diabetic model. Graded doses of the ethanolic heartwood extract were administered to normal and experimental diabetic rats for 12 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the bijasar heartwood by Indian herbal practitioners for treatment of diabetics in different part of the Indian...
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Posted by admin on Dec 1, 2014 in |
Ravenala madagascariensis Sonn. is one of the most popular medicinal plants in Madagascar, India and several African countries. It is used in the treatment of many diseases, and particularly in those of diabetes. The duration of treatment, often for life, and its relatively high cost for certain social categories, constrain more and more patients to use this plant. Its chemical constituents were still little studied and this problem could create significant damage in case of intoleranceor abuse during its use.The present study undertaken on the leaves of Ravenala madagascariensis, led to the isolation and structural elucidation of two new compounds (1 and 2), together with the known cycloartanol triterpene (3) which was isolated for the first time from this plant. Their structures were elucidated as (2E, 7R, 11R) phytyl-3, 7, 11, 15-tetramethylhexadec-2-enyl pentadecanoate (1) and (24S, 31S)-cycloartan-31, 32-diol (2). Structural determinations were made on the basis of analysis of 1D and 2D-NMR spectroscopic data. The complete 1H and 13C resonance assignments were also carried out by using 1H-1H COSY,...
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Posted by admin on Dec 1, 2014 in |
The presence of Non-steroidal Anti-Inflammatory drugs (NSAIDs) and β-lactam residues in foodstuff constitutes a potential risk to the human health and undesirable effects on consumers. Now-a-days these drug residues are also recognized as an emerging environmental problem. The present work describes the development of a sensitive, reproducible, and accurate method using liquid chromatography with ultraviolet detector for simultaneous determination of the (NSAIDs) and β-lactam antibiotics (paracetamol, nimesulide, amoxicillin, and ampicillin) in buffalo raw milk. The extraction method involves liquid-liquid extraction using diethyl ether and centrifugation followed by evaporation under pressure using Nitrogen. The percentage recovery of the (NSAIDs) and β-lactam antibiotics was 85 and 90 % respectively with relative standard deviations between 0.4 and 0.9%. The limits of quantification (LOQs) for all these compounds were in the range of 1 to 3 ng/ml, which are lower than the Maximum Residue Limits (MRLs) established by the Food and Drug Administration (FDA) for the studied (NSAIDs) and β-lactams in milk, making the method suitable for performing routine analysis. The methods were...
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Posted by admin on Dec 1, 2014 in |
A rapid and sensitive RP-HPLC method with UV detection and UV spectrophotometric method for the determination of Lamivudine, Tenofovir and Efavirenz simultaneously in combined tablet dosage form was developed. Chromatography was performed with mobile phase containing a mixture of methanol: Water (pH adjusted to 2.5) and 0.1 % TEA in the proportion of (68: 32 % v/v) the samples were injected onto Symmetry C18 Column (4.6 x 100mm, 5μm, Make: HYPERSIL ODS) column. The flow rate was 1.2ml.min–1. The samples were detected at 260nm. The UV spectrophotometric method was performed at 272nm for Lamivudine, 260 nm for Tenofovir and 247 nm for Efavirenz, and samples were prepared with a solution of Water methanol (30:70 % v/v). The assay was linear in range from 25% to 150% targeted concentration and regression coefficient for all three drugs was found to be 0.999 highly significant for the method. The proposed methods were simple, rapid, precise, accurate and sensitive, and can be used for the routine of the quality control in...
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