Posted by admin on Dec 25, 2014 in |
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance data reveals that all metal chelates of schiff bases are non electrolytes. IR spectra show that ligand is coordinated to the metal ion in a bidentate manner. From the magnetic and electronic spectral data it is found that the geometrical structures of these complexes are square planar. The activity data show the metal complexes to be more potent antifungal and antibacterial than the parent schiff base ligands against one or more fungal and bacterial...
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Posted by admin on Dec 25, 2014 in |
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and night blindness, skin and stomach disorders, ulcer, common fever, rheumatism, bronchitis, cancer etc., Leaves are the most widely used plant part. During the present study it has been observed that the ethnobotanical systems and herbal medicines as therapeutic agents are of a paramount importance in addressing health problems of traditional communities. The indigenous knowledge available with these people plays an important role in quick and proper identification of natural...
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Posted by admin on Dec 25, 2014 in |
The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD50 value. Our studies was extended to include the effect of the tested doses on different biochemical parameters including serum glucose concentration, transaminases and phasphatse activities, total protein, albumin, urea, uric acid, and creatinine levels in serum. In diabetic mice, serum glucose concentration, transaminases and phasphatse activities, urea, uric acid and creatinine levels were significantly increased but level of serum total protein and albumin were decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of E. alba leaves (200 mg/kg b. wt.), on comparison with diabetic group showed a significant decrease in transaminases and phasphatse...
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Posted by admin on Dec 25, 2014 in |
The objective of study to evaluate a drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for comparing the test drug diazepam 4mg/ kg applied transcranially, whereas both water for injection intraperitoneally and seasme oil transcranially used as a control group. In rod walking test and locomotor activity test used mice for evaluating transfer latency and mean locomotion for 05 minutes and it was observed that Diazepam transcranially has a significant amnesic effect (p<0.0001) as compared to control, and as same like standard. In elevated plus maze, morris water maze, and the pole climbing test have been used rats for evaluating transfer latency, escape latency and avoidance latency; it was observed that Diazepam transcranial has a significant amnesic effect (p<0.0001) as compared to control, and...
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Posted by admin on Dec 25, 2014 in |
Members of the genus Ipomoea of family Convolvulaceae besides being some of the most beautiful ornamental plants cultivated for their bell shaped flowers, are also of medicinal value, with some of them reported as cytotoxic agents against some cancer cell lines. The present study evaluates the anticancer activity of the leaf extracts of ten Ipomoea Jacq. Species growing in and around Mumbai, India, on the A 549 cellline and Hep-G2 cell line evaluated by the SRB assay. The crude aqueous extracts of leaves of Ipomoea species studied had significant cytotoxic effect on HEP G2 Cell Line and showed significant inhibitory effect on A549 cell line. , I. Cairica was the best growth inhibitor (GI50at 30.6µg/ml) for HEP G2 cell line followed by I. Hederifolia (GI50 at 38.1 µg/ml), I. Carnea (GI50 at 40.0 µg/ml). Considering the A549 cell line, none of the crude extracts showed GI50 inhibition upto80 µg/ml with the exception of I. aquatic which showed GI50at 75.6...
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