Posted by admin on Dec 25, 2014 in |
The two pure phytochemicals characterized as cis-piperine and trans-piperine isolated from the dried fruits of Piper longum were tested for antihepatotoxic activity at the dose of 50 mg/kg orally respectively, against silymarin as a standard reference. The toxicity was induced by CCl4, and then various biological parameters such as AST, ALT, ALP, SOD, GPx, GSH, total protein, total albumin and total bilirubin were measured at 134.24 IU/L 71.96 IU/L, 375.02 IU/L, 37.02 U/g, 17.02 U/g, 29.12 U/g, 1.95 g/dl, 1.09 g/dl, 4.16 g/dl respectively. The phytochemicals cis-piperine and trans-piperine showed significant antihepatotoxic activity. Both cis-piperine and trans-piperine exhibited antihepatotoxic activity by reducing the increased levels of serum AST by 90.14%, 91.19% ALT by 82.65%, 58.12% and ALP by 97.37%, 92.23% when compared with standard drug silymarin that have decreased AST by 91.64%, ALT by 89.92%, ALP by 94.54%, respectively, and by elevation in the antioxidants SOD, GPx, and GSH) respectively, and total albumin, total protein. The overall experimental results have suggested that the both the isomers of piperine possessed...
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Posted by admin on Dec 25, 2014 in |
The aim of this study was to investigate the possible anticonvulsant effect of a Dihydropyridine calcium antagonist, Isradipine, which easily crosses the blood–brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures and PTZ induced seizures. The seizures were induced in rats by maximum electroshock method and chemically by pentylenetetrazole (PTZ). Isradipine delayed the onset of action and time of death to 213.21 ± 32.46 seconds and 952.85 ± 9.81 seconds respectively when compared with control in PTZ induces seizures model. The present study indicates that Isradipine showed significant anticonvulsant effect against maximal electroshock and PTZ induced convulsion in...
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Posted by admin on Dec 25, 2014 in |
The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol also possess anti-cancer properties in addition to its sedative effects. Cytotoxicity of all the synthesized compounds was examined against a panel of four human solid tumor cell lines, SK-MEL, KB, BT-549, SK-OV-3, and one human leukemia cell line, HL-60. To compare their tumor selectivity over normal cell lines, VERO cells were also included. The results indicate that these novel conjugates might represent a new class of anti-tumor agents that possess selectivity toward cancer cells over normal...
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Posted by admin on Dec 25, 2014 in |
The present study aimed to evaluate bioactive compounds and total antioxidant activity of differentfruits viz Phyllanthus emblica, Limonia acidissima, Syzygium cumini, Artocarpus hirsutus, Carissa congesta, Anacardium occidentale. Phytochemical study confirms the presence of carbohydrates, proteins, amino acids, cardiac glycosides, steroids, terpenoids and flavonoids in all the fruit extract. Ascorbic acid was used as a standard antioxidant. The reducing power and total antioxidant activity were high in Phyllanthus emblica and low in Carissa congesta. In DPPH assay Phyllanthus emblica exhibited highest activity whereas A.hirsutus showed lowest activity. Thus the study suggests that Phyllanthus emblicafruit is a better source of natural antioxidant, which might be helpful in preventing oxidative stress related...
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Posted by admin on Dec 25, 2014 in |
Objectives: To determine the incidence, causes, patterns, outcomes and predictors of medication errors (ME) in psychiatric practice. Methodology: A prospective observational study was conducted in the psychiatry department of a tertiary care hospital over a period of 6 months. Patients of either sex and aged ≥ 18 years receiving at least one psychotropic agent were included in the study and analyzed for the ME. The collected data was analyzed for the incidence, causes and patterns of medication errors. Predictors of medication errors were determined using bivariate non parametric analysis. The variables considered to determine predictors were age, gender, length of hospital stay and number of medications. Results: During the study period 215 medication errors were identified from 166 patients and the incidence of medication error was found to be 1.3 per patient. The average number of ME in a patient was 2.1. The most common types of medication errors observed were dose omission (42.12%), wrong technique (11.57%) and wrong administration (10.60%). Factors responsible for medication errors were performance deficit...
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