Posted by admin on Dec 1, 2014 in |
A number of trisubstituted 2-pyrazolines which are known for their biological importance like antimicrobial, anti-inflammatory, antitubercular, analgesic, anticancer, antimalarial, anti-viral, antihelmentic activities are prepared by reacting chalcones with phenyl hydrazine in absolute ethanol in presence of pyridine. In the present investigation an attempt has been made for the synthesis of 2-pyrazoline derivatives and subjected to molecular properties prediction by molinspiration, molsoft and osiris softwares. The synthesized compounds have been confirmed by IR, Mass and 1HNMR spectral data. These compounds were also screened for various biological activities like antifungal, anti-inflammatory and acute toxicity activity by standard methods. The synthesized compounds have shown moderate to good antifungal, anti-inflammatory activity and some of the synthesized compounds have shown significant activity as compared with standard. Compound 5d showed good antiinflammatory activity, compounds 5c, 5d, and 5e showed higher antifungal activity and all the synthesized compounds were found to be in conformity with lipinski’s...
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Posted by admin on Dec 1, 2014 in |
Baccharis trimera is used in traditional medicine in South American countries for treatment of diseases, such as digestive disturbances, rheumatism, diabetes and inflammatory processes. Given its pharmacological potential, the aim was to characterize the vegetal drug B. trimera and attain and standardize its lyophilized extract to use as raw vegetal material in the development of phytotherapeutic medicine. Chemical identification and prospecting, granulometric determination, loss by desiccation, total ash and caffeic acid through High-Performance Liquid Chromatography were carried out. The lyophilized extract obtained was submitted to assays for determining caffeic acids, rheology, hygroscopicity, solubility, superficial area, porosity, particle size through laser granulometry and the thermogravimetric curve. The assays demonstrated that the sample is within the described specifications in literature and, therefore, is adequate to obtain the liquid extract and later dry and standardized in relation to the content of caffeic acids. The lyophilized extract was fine powder, demonstrating the necessity for addition of excipients that make possible the use of the input for the attainment of solid pharmaceutical forms. It...
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Posted by admin on Dec 1, 2014 in |
The interaction of omeprazole with different types of antibiotics was investigated in biological buffer at physiological pH=7.4 by using electrochemical (cyclic and linear sweep voltammetry) method. The reduction processes of omeprazole in the absence of and in the presence of azithromycin, clarithromycin, roxithromycin and doxycyclline are irreversible. Omeprazole interacts in solution with antibiotics structures by a predominantly electrostatic mechanism. From electrochemical data, The 1:2, 1:1, 1:1 and 1:2 complexes of azithromycin-omeprazole, clarithromycin-omeprazole, roxithromycin-omeprazole and doxycycline-omeprazole are formed with the binding constants β = 3.930 (±0.15), 0.985 (±0.02), 0.321 (±0.01) and 8.230 (±0.21) µM-1 respectively. The results show that, the binding affinity of omeprazole increases in the sequence: roxithromycin > clarithromycin > azithromycin >...
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Posted by admin on Dec 1, 2014 in |
Leaves and flowers of Inula viscosa (L.) were collected from fields in Al-Qadmous, Syria. Essential oil was isolated by classical method of hydro distillation using the Clevenger-type apparatus. Its chemical composition was analyzed by GC/MS. The analysis led to the identification of48 and 43 components in flowers and leaves, respectively. Essential oils were characterized by a high content of oxygenated sesquiterpenes (53.85% and 54.29%, respectively), with E-Foreseen Epoxide (22.41 % and 16.55%, respectively) and Nerolidol B (15.70% and 13.64%, respectively), as the main...
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Posted by admin on Dec 1, 2014 in |
Arnica montana L. (Asteraceae) is a valuable medicinal plant species, endemic to Europe, which is threatened in many countries due to its overharvesting. The increasing market demand requires development of an effective method for A. montana rapid propagation, offering the possibility for its field cultivation as an alternative to plant gathering from nature. Three in -vitro culture systems were compared to determinethe best shoot multiplication of A. montana: agar-gelled medium, static liquid medium and Temporary Immersion System (TIS RITA®). Murashige and Skoog (MS) nutrient medium supplemented with 1 mg/l BA and 0.1 mg/l IAA was used in all experiments. The highest micropropagation rate (18.2 shoots/explant,for 5 weeks) was obtained via TIS culture. Besides, these plants showed higher sesqiuterpene lactones content than those derived from the other tested systems. The shoots were successfully in -vitro rooted and ex-vitro adapted. The elaborated method for mass multiplication of A. montana allows significant enhancement of the in -vitro process and could be applied to produce planting material, thus contributing to the conservation of...
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