Posted by admin on Jan 31, 2015 in |
Objective: The aim of this study was to evaluate the sleep quality and to identify risk factors for poor sleep quality in hemodialysis population. An additional aim of the study was to identify number of patients treated for their sleep problems. Method: 126 patients undergoing hemodialysis treatment were enrolled into the study. Subjective sleep quality was measured using Pittsburgh Sleep Quality Index. All the participants also completed Beck Depression Inventory questionnaire for evaluation of depressive symptoms. The pharmacotherapy and clinical, demographic and socioeconomic variables were also investigated. Results: Among the enrolled patients, poor sleep quality was reported in 67% (n=85). Depressive symptoms were identified in 75% (n=62) of the poor sleepers. Significant association was observed between variables like being single, female gender, older age, low socioeconomic status, increased financial reliability, spending more than INR 10,000 ($ 166) per month for treatment, overweight, morning dialysis shift and dialysis duration more than 3 years. Clinical conditions like depression, diabetes, limb pain, fatigue, hypertension, hypoalbuminemia, hypocalcaemia and hypophosphatemia and use of medications...
Read More
Posted by admin on Jan 31, 2015 in |
The present study investigated the phytochemical analysis of the major bioactive constituents of medicinal important plant of Punica granatum peels in its aqueous extract and green synthesis of silver nanoparticles and their evaluation for antibacterial activity. Flavonoid, phenol & tannins, carbohydrates, glycosides and etc were highly concentrated in the peels extract. The synthesis and characterization of silver nanoparticles was confirmed by UV-Visible spectroscopy. UV-Visible spectroscopy of the reaction medium containing silver nanoparticles show the maximum absorbance peaks 430nm (1%), 373nm (3%), 379nm (5%). Green synthesis of silver nanoparticles analyzed against bacterial cultures by using the disc diffusion method. The silver nanoparticles have shown bactericidal effects against E.coli (MTCC-40), Staphylococcus aureus (MTCC-7443), Proteus vulgaris (MTCC-*1771). The peels extract of Punica granatum quikely reduces Ag+ to Ago and enhance synthesis of silver nanoparticles with highly antibacterial...
Read More
Posted by admin on Jan 31, 2015 in |
Cancer is a class of disease, where the cells uncontrollably divide without any control over cell cycle and cell division. Various factors contribute to cause of cancer in many ways. Ultimately the cancer cell proliferates without control over cell cycle. Many factors involve in cell cycle amongst that one of the ideal target is Cyclin D1 which couples with cyclin dependent kinase 4, phosphorylates it and this complex promotes cell cycle to next phase. It has been proven that Cyclin D1 inhibition can prevent the progress of many cancers, particularly the breast cancer. So, in the present study Cyclin D1 is exclusively considered as a potent target and by using various commercial softwares and on line tools and databases a couple of drugs have been designed to bind to and inhibit Cyclin D1 and prevent the progress of cell cycle in cancerous cells, and all the designed molecules are evaluated for its pharmacokinetic properties, toxicities, potencies, pharmacophore and lastly its binding ability with the target has been studied and...
Read More
Posted by admin on Jan 30, 2015 in |
Phospholipase A2 is the enzyme that catalyzes the hydrolysis of the sn-2 fatty acyl bond of phospholipids, liberating free fatty acids and lysophospholipids. These enzymes are found in mammalian tissues, insects, reptiles, urochordates, invertebrates and echinoderms. Some of the PLA2 are toxic in nature. Venom from snakes and insects is largely composed of melittin, which is a stimulant of PLA2. In this study, Phylogenetic relationship of Phospholipase A2 were compared, tertiary &secondary structures of PLA2 in different species like Apismellifera, Najaatra, Varanusscalaris, Asterinapectinifera, Mesobuthustumulus, Rophilemanomadica were...
Read More
Posted by admin on Jan 30, 2015 in |
Objective: Antibiotics resistance patterns for many bacteria have changed significantly; causing poor clinical outcomes. The objective of the study was to measure the susceptibility of different antibiotics against specific clinical isolates for surveillance purpose. Method: Kirby-Bauer disc diffusion method was used to evaluate the susceptibility pattern of four antibiotics (commercially available disc) i.e., Amoxicillin, Cefixime, Ciprofloxacin and Levofloxacin against different clinical isolates collected from various hospitals. The clinical isolates selected for the proposed study were of Staphylococcus aureus, Streptococcus Pneumoniae, Klebsiella Pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and Escherichia coli. This collection of antibiotics and isolates were due to common pathogens and highly prescribed Oral antibiotics. Result: Results show that amoxicillin and cefixime are highly resistant; cefixime is sensitive against Salmonella typhi and Streptococcus Pneumoniae but 50 % resistant to the microbes. In quinolones, ciprofloxacin and levofloxacin have good sensitivity; Levofloxacin is a better choice against aforementioned pathogens. Conclusion: It was concluded that bacterial resistance rates vary among species and also from hospital to hospital. Irrational uses of antibiotics cause...
Read More
