Posted by admin on Dec 25, 2014 in |
The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol also possess anti-cancer properties in addition to its sedative effects. Cytotoxicity of all the synthesized compounds was examined against a panel of four human solid tumor cell lines, SK-MEL, KB, BT-549, SK-OV-3, and one human leukemia cell line, HL-60. To compare their tumor selectivity over normal cell lines, VERO cells were also included. The results indicate that these novel conjugates might represent a new class of anti-tumor agents that possess selectivity toward cancer cells over normal...
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Posted by admin on Dec 25, 2014 in |
The present study aimed to evaluate bioactive compounds and total antioxidant activity of differentfruits viz Phyllanthus emblica, Limonia acidissima, Syzygium cumini, Artocarpus hirsutus, Carissa congesta, Anacardium occidentale. Phytochemical study confirms the presence of carbohydrates, proteins, amino acids, cardiac glycosides, steroids, terpenoids and flavonoids in all the fruit extract. Ascorbic acid was used as a standard antioxidant. The reducing power and total antioxidant activity were high in Phyllanthus emblica and low in Carissa congesta. In DPPH assay Phyllanthus emblica exhibited highest activity whereas A.hirsutus showed lowest activity. Thus the study suggests that Phyllanthus emblicafruit is a better source of natural antioxidant, which might be helpful in preventing oxidative stress related...
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Posted by admin on Dec 25, 2014 in |
Objectives: To determine the incidence, causes, patterns, outcomes and predictors of medication errors (ME) in psychiatric practice. Methodology: A prospective observational study was conducted in the psychiatry department of a tertiary care hospital over a period of 6 months. Patients of either sex and aged ≥ 18 years receiving at least one psychotropic agent were included in the study and analyzed for the ME. The collected data was analyzed for the incidence, causes and patterns of medication errors. Predictors of medication errors were determined using bivariate non parametric analysis. The variables considered to determine predictors were age, gender, length of hospital stay and number of medications. Results: During the study period 215 medication errors were identified from 166 patients and the incidence of medication error was found to be 1.3 per patient. The average number of ME in a patient was 2.1. The most common types of medication errors observed were dose omission (42.12%), wrong technique (11.57%) and wrong administration (10.60%). Factors responsible for medication errors were performance deficit...
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Posted by admin on Dec 25, 2014 in |
ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and acetonitrile (45: 55 v/v) as mobile phase at flow rate of 1.2 mL/min. In this developed method Clopidogrel and Rosuvastatin eluted at a retention time of 4.697 and 3.337 min respectively. The proposed method is having linearity in the concentration range from 10 to 50μg/mL of Clopidogrel and Rosuvastatin. The current method was validated with respect to linearity; precision, lowest limit of detection (LOD), accuracy and recovery according to the USFDA guidelines. The system consisted of a pump (Shimadzu, prominence, UFLC), with 20µl sample injector, along with a PDA detector at a wavelength of 243 nm and 220 nm for Rosuvastatin and Clopidogrel respectively. Data was compiled using Shimadzu LC Solution software. A...
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Posted by admin on Dec 25, 2014 in |
Octenyl succinate derivatives (OSA) of cassava starch having different degree of substitution (DS) were synthesized by microwave irradiation in solid state using a monomode reactor and the drug, theophylline (Thp) was successfully incorporated in the modified starches for getting controlled release properties. The reaction conditions were optimized for maximizing the DS by response surface methodology and it ranged from 0.002 to 0.021, for the different modified starches. Pre-formulation study was done by Fourier transformed infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) for testing the drug-excipient compatibility. Drug incorporated tablets were prepared using the modified starches and their properties were studied. The spectral and DSC studies showed that there was a good compatibility between OSA starch matrix and theophylline. The in vitro drug release study was performed under different conditions of pH and time as well as after storage of the tablets for different time durations. The in vitro release rate was found to be significantly related to the DS of the modified starch and more sustained release of...
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