Posted by admin on Oct 1, 2014 in |
Background and Objectives: Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. One of the leading causes of diabetes mellitus related morbidity and mortality is diabetic nephropathy. The earliest stage of diabetic nephropathy is Microalbuminuria, which is the excretion of extremely small quantities of albumin in the range of 30 – 300 mg/day. Hypomagnesaemia may be a risk factor for the progression of complications in type 2 diabetes mellitus. Material and Methods: The material for the present study comprised of 60 patients of type2 diabetes mellitus. Glycosylated hemoglobin, serum magnesium, and urinary microalbumin were measured. Results: It was found that the glycemic control, as indicated by glycosylated hemoglobin, is related significantly to microalbuminuria. Poor glycemic control leading to renal damage causes microalbuminuria. A significant inverse correlation between serum magnesium and urinary microalbumin levels was also observed. Conclusion: Estimation of urinary microalbumin, glycosylated hemoglobin and serum magnesium should be routinely done in confirmed cases of type 2 diabetes mellitus....
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Posted by admin on Oct 1, 2014 in |
In the present study antiurolithic activity of various extract of the whole plant of Ageratum consider Linn. was investigated on experimentally urolithiasis induced male albino wistar rats. Urolithiasis was induced in animals by using ethylene glycol (5% v/v, 2ml/rat/7days). Experimental induction of hyperoxaluria results in the rapid formation of calcium oxalate crystals in the renal tubules of experimental animals. The investigation was done based on estimation of stone-forming constituents oxalate, calcium, and phosphate, in kidney and urine. Treatment with ethyl acetate, ethanol and aqueous extract (500mg/kg, p.o) of Ageratum conzoides, the standard group treated with calculi (500mg/kg, p.o) and a positive control group treated with the only saline. The results are compared with calculi, ethanolic extracts, and ethyl acetate extract are significantly lowered the increased levels of oxalate, calcium, and phosphate in urine and also significantly reduced their retention in the kidney. The presented data indicate that administration of Ageratum conzoides extracts decrease urolithiasis and also prevented the formation of urinary stones; it proves the antiurolithiatic activity of the...
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Posted by admin on Oct 1, 2014 in |
Comparative DFT calculations have been studied for Paracetamol (PA) and its analog Phenacetin (PH) to verify their electronic resemblance. DFT studies concluded that PA and PH have the lower energy predominant trans conformers with respect the cis-conformers. From TD-DFT studies, the electronic transition energies between the ground state and singlet excited states for the two conformers have been done. The metabolized product of PA or PH, i.e., m-PA in the liver of the human being is N-acetylimidoquinone. The electron affinity, Ea, of metabolized Paracetamol (m-PA) is sufficient to interact with the nucleic acid bases in the liver. So long as the m-PA product is produced in the liver and the electron transfer energy, Eet, between m-PA and nucleic acid bases has very small energy value with guanine, i.e., 0.382 eV, from the nucleus of the cell in the liver producing a spontaneous electron transfer from the nucleus to m-PA producing cationic nucleus leading to the carcinogenic behavior of the cell in the liver. The presence of glutathione in the...
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Posted by admin on Oct 1, 2014 in |
In recent years, a large number of oils and their constituents have been investigated for their antimicrobial properties against bacteria and fungi. The present investigation evaluated the antimicrobial potential of edible medicinal oils of Cocos nucifera, Helianthus annus, Brassica juncea, Ricinus communis, Arachis hypogea, Glycine max, Gossypium hirsutum and Sesamum indicum extracted from different solvents. There is a basis for the traditional use of these plants for local health remedies. Oils of these plants were screened for their antimicrobial activity against human pathogenic bacteria and fungi, causing skin diseases. The antimicrobial activity of these oils was investigated against Escherichia coli, Trichophyton rubrum and Candida albicans by agar well diffusion method, Helianthus annus seed oil showed maximum antimicrobial activity against tested bacteria and fungi with MIC values ranging from 0.62 to 40 mg/mL using inhibitory zone estimation. These results support the edible medicinal oils can be used to cure skin...
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Posted by admin on Oct 1, 2014 in |
Hippophae rhamnoides, is known well for its cardioprotective, immunomodulatory, and antioxidant property; hence an effort was taken to evaluate its neuroprotective effect on scopolamine-induced neurochemical impairment and cognitive dysfunction. Male Sprague Dawley rats were induced with 2 mg/kg body weight of scopolamine as a single dose for 14 days, along with test formulation for four weeks and its efficacy was assessed on the cholinergic and other neurotransmitter systems according to standard laboratory method. It was found that the neurotoxin scopolamine elicited marked decrease in the level of neurotransmitters and cognitive function. A significant increase was found in the level of neurotransmitters, ChAT enzyme activity, and active avoidance learning score after the treatment of with test formulation showing values of P<0.05 & P<0.001. The study thus provides evidence for the potential effect of H. rhamnoides in improving the cognitive functions by stimulating the cholinergic system. Hence, it may be useful in the future as an alternative medicine for neurodegenerative disorders especially those of Dementia and Alzheimer’s after further confirmations and...
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