Posted by admin on Dec 1, 2014 in |
Leaves and flowers of Inula viscosa (L.) were collected from fields in Al-Qadmous, Syria. Essential oil was isolated by classical method of hydro distillation using the Clevenger-type apparatus. Its chemical composition was analyzed by GC/MS. The analysis led to the identification of48 and 43 components in flowers and leaves, respectively. Essential oils were characterized by a high content of oxygenated sesquiterpenes (53.85% and 54.29%, respectively), with E-Foreseen Epoxide (22.41 % and 16.55%, respectively) and Nerolidol B (15.70% and 13.64%, respectively), as the main...
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Posted by admin on Dec 1, 2014 in |
Arnica montana L. (Asteraceae) is a valuable medicinal plant species, endemic to Europe, which is threatened in many countries due to its overharvesting. The increasing market demand requires development of an effective method for A. montana rapid propagation, offering the possibility for its field cultivation as an alternative to plant gathering from nature. Three in -vitro culture systems were compared to determinethe best shoot multiplication of A. montana: agar-gelled medium, static liquid medium and Temporary Immersion System (TIS RITA®). Murashige and Skoog (MS) nutrient medium supplemented with 1 mg/l BA and 0.1 mg/l IAA was used in all experiments. The highest micropropagation rate (18.2 shoots/explant,for 5 weeks) was obtained via TIS culture. Besides, these plants showed higher sesqiuterpene lactones content than those derived from the other tested systems. The shoots were successfully in -vitro rooted and ex-vitro adapted. The elaborated method for mass multiplication of A. montana allows significant enhancement of the in -vitro process and could be applied to produce planting material, thus contributing to the conservation of...
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Posted by admin on Dec 1, 2014 in |
Background: Drug induced liver injury (DILI), especially; due to use of immunosuppressive agents is a growing concern. Lack of awareness about available treatment options limits its management. This observational study was conducted to characterize Russian population receiving ademetionine as a hepatoprotectant against DILI triggered due to immunosuppressive drugs. Methods: A total of 105 patients having DILI with cholestasis (by immunosuppressives) aged 18-65 years were enrolled in a multicentric, non-interventional, prospective observational study. The study had three phases (Start up: Ademetionine intravenous/intramuscular 400-800 mg/day, 2 weeks; Maintenance: 800-1600 mg/day, 4 weeks, orally; Follow up: At end of 4 weeks post-treatment). Profiling of patients, reasons for prescribing ademetionine and safety parameters were assessed. Changes from baseline in the levels of laboratory parameters, signs and symptoms of cholestasis and depressed mood were also assessed. Results: All enrolled patients were Caucasian (44.4 years; smokers: 41.9%; consumed alcohol daily: 31.4%; history of psoriasis: 86.7%). Methotrexate was the most commonly used immunosuppressive agent (used in 80.0% of patients). Post treatment with ademetionine, levels of various...
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Posted by admin on Dec 1, 2014 in |
The decoction of Simarouba amara stem bark has been used to treat malaria, inflammation, diarrhea and as tonic. The aim of this study was to evaluate acute and subacute toxicities of the aqueous extract of S. amara stem bark (SAAE) in rats and mice, respectively. For the acute toxicity test, the SAAE was administered in a single oral dose of 2.0 g/kg (n = 5/group/sex) and in the subacute, the following doses were used: 0.25, 0.5 and 1.0 g/kg/day (n = 12/group/sex, p.o.), for 30 consecutive days. In the acute toxicity, SAAE did not produce mortality nor clinical signs of toxicity. The subacute treatment did not alter water intake, however, in the last week there were reductions body mass gain of males and females treated with the highest dose. The males showed increased levels of total protein and albumin (all doses), of alkaline phosphatase and total bilirubin (doses of 0.5 and 1.0 g/kg) and leukocytosis (1.0 g/kg). The females showed hyperuricemia (0.5 and 1.0 g/kg), hypertriglyceridemia (1.0 g/kg) and...
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Posted by admin on Dec 1, 2014 in |
The aim of this work was to investigate of the antimicrobial and antioxidant potentials of methanol extracts from Ficus carica. Methanol extracts were screened for antimicrobial activity against different species of Gram positive andGram negative bacteria and one yeast. The methanol extract of Ficus carica showed maximum inhibition zone of 10 mm against Listeria monocytogenes. In addition to, the plant extracts were tested against the stable DPPH (2, 2-diphenyl-1-picryl-hydrazyl-hydrate) free-radical. Trolox was chosen as a standard antioxidant. Finally, the methanol extract displayed a strong antioxidant activity (Trolox equivalent= 1.33 mM). Ficus carica methanol extracts have antimicrobial and antioxidant...
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