Posted by admin on Nov 1, 2014 in |
Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies. . Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted acetophenone with thiosemicarbazone in the presence of hot ethanol. All the transition-ligands 1:2 complexes have been isolated in the solid state, are stable in air, and characterized on the basis of their elemental and spectral data. They were found to be active against influenza, protozoa, small pox, and certain kinds of tumor. Their metal complexes were used, in various biological systems, polymers, dyes, anti-inflammatory, analgesic and anti-oxidative action. The Schiff bases and their metal complexes were used in various biological activities such as antimicrobial, antifungal, antiviral, insecticides, and antitumor...
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Posted by admin on Nov 1, 2014 in |
The acute dental abscess is frequently underestimated in terms of its morbidity and mortality. The risk of potentially serious consequences arising from the spread of a dental abscess is still relevant today with many hospital admissions for dental sepsis. Acacia nilotica was commonly known in India as Babul has a wide range of medicinal uses. In the present study antibacterial activity of different parts of Acacia nilotica was studied to evaluate their potential for being used as natural antibacterial agent against various dental infections. The bioactivity Acacia nilotica was analyzed crude extracts of bark, leaves, and Pod of Acacia nilotica against five dental pathogens (Lactobacillus acidophilus, Streptococcus sanguinis, Streptococcus salivarius, Aggregatibacter actinomycetemcomitans) using agar diffusion technique and determine the minimum inhibitory concentration of each extract against the dental pathogen. The present study conducted to evaluate the highest anti dental infection property of different extract of Acacia nilotica. In this study the pod extract shows highest antibacterial potential followed by the bark extract and leaves...
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Posted by admin on Nov 1, 2014 in |
The increasing resistance of microbes to conventional drugs has promoted the scientists to search for new biocides with broad activity. Plant derived essential oils (EOs) have been known to show antimicrobial activity against specific pathogens and therefore could be considered as alternative antimicrobial agents in controlling pathogens. The present study was done to investigate the antimicrobial activity of soybean, rice, mustard, olive, coconut and castor oil against 24 isolates of 6 different types of food borne pathogens. Antibacterial activities of essential oils were determined using agar disc diffusion assay. All EOs showed antibacterial activity against Escherichia coli, Pseudomonas sp., Staphylococcus aureus, Vibrio cholerae, Klebsiella spp., and Salmonella spp. Staphylococcus aureus was found more sensitive to soybean and mustard oils compared to other Gram negative bacteria. Castor oil was effective against most of the bacteria namely Escherichia coli, Staphylococcus aureus, Vibrio cholerae, Klebsiella spp. and Salmonella spp. The antibacterial activity of EOs could be used for treatment of bacterial infection and preservation of...
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Posted by admin on Nov 1, 2014 in |
Halfmer of chicoric acid derivatives in two series were planned to synthesized and evaluated for their capacity to reduce the viral load in the human plasma by ROTOR GENE-Q (5 Plex) Real Time PCR method to check their biological activity. Different substituted hydroxy cinnamic acids has been conjugated with different amino acid in N-series and in K-Series same substituted hydroxy cinnamic acids has been conjugated with thio derivative of same amino acids In Anti-HIV evaluation K series (Containing Sulfur as a linker) was found to be have highest activity in terms of in-vitro viral load. Compound K-11 (2-{[(2E)-3-(4-hydroxyphenyl) prop-2-enoyl]-sulfanyl}propanoic acid) was found to be most active with viral load 72 copies/ml and 91.69% decrease in viral load. Among two series K (Mercapto series) is more active and among all compounds K-11 is most active compounds against HIV-1 virus in terms of viral load. So, the activities of compounds constitute a strong rationale for further...
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Posted by admin on Oct 31, 2014 in |
A new simple and rapid reverse-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250 × 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The eluents were monitored at 236 nm by using PDA detector. The retention time for cefpodoxime proxetil was found to be 4.5 min, respectively. The cefpodoxime proxetil followed linearity in the concentration range of 5-30 μg/mL (r2 = 0.998). The amount of drug estimated by proposed method was found to be in good agreement with label claim. The developed method was validated for sensitivity, accuracy, precision. The LOD and LOQ values were found to be 0.0004 and 0.0012 μg respectively for cefpodoxime proxetil. The proposed method can be used for routine analysis of both these drugs simultaneously in their combined dosage...
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