Posted by admin on Oct 1, 2014 in |
Selenium (Se) plays a vital role in maintaining the body’s homeostasis. Selenoproteins have been found to play an integral role in the body’s defense against oxidative stress. Type-2 diabetes mellitus is considered as an inflammatory state with high oxidative load and is one of the major chronic diseases prevalent in Pakistan. Serum levels of selenium in type 2 diabetic patients and healthy individuals were determined. The sample size consisted of 120 subjects. Inductively coupled plasma optical emission spectrometry was used for the serum selenium determination. Statistical analysis was done at the confidence interval (CI) of 95%. No significant difference was determined in the mean serum selenium levels of type 2 diabetic patients and healthy persons. Moreover, the studied population was observed to be selenium-replete population. Hence, laboratory evidence for prescribing selenium supplement is of vital importance and requires extreme care irrespective of the involvement of oxidative stress...
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Posted by admin on Oct 1, 2014 in |
Treatment of implant-related MRSA osteomyelitis is a real challenge both for the physician and the patient. We evaluated the comparative efficacy of tigecycline, a novel broad-spectrum glycycline antibiotic and the glycopeptide antibiotic teicoplanin in the treatment of implant-related MRSA osteomyelitis in an experimental rat model. Implant related MRSA osteomyelitis was studied in the tibial metaphysis of 60 rats. When compared to the control groups, the number of microorganisms was found to be significantly lower in the study groups, but there was no statistically significant difference between tigecycline and teicoplanin. respectively. Tigecycline with its good tissue penetration and lower side effects were found to be as effective as teicoplanin in implant-related MRSA osteomyelitis, even if the implant is retained. It could be considered as an alternative to glycopeptides because of the efficacy and because of the lower adverse effects in long term usage. Further studies are warranted to suggest a standard medical treatment for implant-related...
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Posted by admin on Oct 1, 2014 in |
The present study compiled the formulation and standardization of polyherbal liver syrup named “LivPro” followed by in-vivo and in-vitro hepatoprotective activity in CCl4 intoxicated rat. LivPro was formulated by using the lyophilized ethanolic extract of A. millefolium, C. spinosa, C. intybus, and P. kurroa. Further, the standardization of LivPro was performed following the guidelines of WHO and Indian Pharmacopoeia. Wistar albino rats were treated with vehicle, silymarin, and LivPro (5, 10 and 15 ml/kg) continuously for 14 days. CCl4 was administered on every alternate day for a week. Results postulated that LivPro had pH 5.04, specific gravity 0.8269; viscosity 78.01 poise, relative density 1.271 gm/ml, and refractive index 1.432. LivPro showed a rich quantity of flavonoid (480 mg/gm), total phenol (396 mg/gm) and alkaloid (103 mg/gm). The concentration of lead and arsenic in the tested formulation was found to be within the limit. The total plate count and viable aerobic microbial count in the formulation were 480, and 415 CFU/gm and the yeast and mold count was less than 100...
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Posted by admin on Oct 1, 2014 in |
Spontaneous reporting of adverse drug reactions (ADRs) is a broadly experienced technique of practicing pharmacovigilance (PV) activity. However, the progression of pharmacovigilance programs is limited by under-reporting of ADRs, as it is considered one of the major problems associated with PV programs development. This is the first study of its kind in the United Arab Emirates (UAE) that examines what inhibits and what motivates the community pharmacists (CPs) to report ADRs. Face to face questionnaire was used for data collection. Random sampling method was used to approach the potential respondents. Descriptive analysis was conducted using SPSS 20. Many barriers had been revealed that prohibit pharmacists participation in PV program; unavailability of reporting forms (81.8%), unknown address to contact (79.8%), the belief that all serious ADRs are detected before registration (70%), pharmacists unfamiliarity of how to report (69.1%) were the commonly shared reasons for under-reporting by CPs. Also, the majority (82.1%) of the respondents agreed that encouraging patients to report ADRs to the pharmacists is an important factor necessary for...
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Posted by admin on Oct 1, 2014 in |
Quantitative Structure-Activity Relationships (QSAR) is based on the assumption that the activity of a certain chemical compound is related to its structure. More precisely, this approach says that the activity or the property is related to the chemical structure through a certain mathematical algorithm or rule. Quantitative structure-activity relationship (QSAR) analysis used to understand the structural factors responsible for PPAR-γ agonistic activity of some 2- Alkoxydihydrocinnamates. Several pharmacophore-based models indicated the importance of steric, hydrophobic, and hydrogen bond acceptor groups to agonistic...
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