Posted by admin on Oct 1, 2014 in |
The present study was aimed to screen the antioxidant activity and phytochemical content of bryophyte species Marchantia paleacea Bertol., Marchantia linearis Lehm. & Lindenb. and Conocephalum conicum (L.) Underw. collected from Darjeeling hills of Eastern Himalaya, India. The free radical scavenging activities were measured in-vitro by DPPH radical, metal chelating, superoxide, ABTS+, reducing power, anti-lipid peroxidation, and nitric oxide scavenging activity. Total phenol, flavonoids, and ortho-dihydric phenol present in the samples were also estimated. Qualitative phytochemical screening was carried out to detect the presence of varied phytochemicals. Thin-layer chromatography (TLC) and TLC bioautography assay were also performed to confirm the presence of different bioactive compounds and its free radical scavenging potential. All the tested bryophyte species showed potential antioxidant activity and the existence of different phytochemicals. The results obtained from this work indicated that all the three bryophyte species analyzed are a potent source for antioxidants and can be pharmaceutically explored in...
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Posted by admin on Oct 1, 2014 in |
From TLC examination of fractions of benzene and benzene: ether (5:5) extract of the stem bark of B. monosperma revealed the separable mixture. These fractions were subjected to rechromatography. Isolated compounds were purified and crystallized by chloroform: methanol. After isolation and purification afforded white crystalline substance which was subjected to physical, chemical and spectral analysis and identified as Tetratriacont -15-ene(1), Hepta cos-11-ene(2), 15-hydroxyl ethylheptadec-12-enoate(3), 10-hydroxy dodecyltridec-5 enoate(4), based on spectral evidence....
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Posted by admin on Oct 1, 2014 in |
In this research study, the effect of drug release of albendazole chewable tablets has been determined. The drug release is calculated by using the disintegration process, which is directly related to the hardness of tablets. The tablets are prepared by using three types of granulating methods are non-aqueous granulation, aqueous granulation, and direct compression. The tablets are evaluated by calculating different parameters such as hardness, friability, disintegration, assay, and in-vitro dissolution studies. The % drug release was determined by using U V spectrophotometry. In the three techniques and the non-aqueous granulation was the better technique for the formulation of tablets, dissolution rate, and % drug release other than aqueous granulation and direct compression method. So by this, we can say the non- aqueous technique gives immediate drug release by which the drug can be used at the time of emergency and gives relief to the patient, and the chewable tablets can use for the children easily. The present study was to prepare the chewable albendazole tablets by granulating techniques,...
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Posted by admin on Oct 1, 2014 in |
Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem, and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl acetate (in 9:1 ratio) and Toluene: Ethyl acetate: Formic acid (in 5:5:0.2 ratio) for PE and chloroform fractions respectively. Result and Conclusion: The results of the preliminary phytochemical screening revealed the presence of various chemical compounds like alkaloids, glycosides, flavonoids, carbohydrates, anthraquinone, tannins, phenols, terpenoids, fixed oil, and fats. The organoleptic study revealed the specific nature of the plant parts used in the study. The behavior of the powdered plant parts in the presence of various chemicals was studied. TLC analysis of the petroleum ether and chloroform fraction of the leaves of Excoecaria agallocha L. revealed bands indicating the presence of various compounds that could act as potential...
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Posted by admin on Oct 1, 2014 in |
Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models. Method: Three LX transdermal patches (F1, F2, and F3) consist of Eudragit RL-100, and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethyl phthalate as a plasticizer. The physicochemical compatibility of the drug and the polymers was studied by differential scanning calorimetry. The prepared LX transdermal patches were evaluated for their drug content, patch thickness, folding endurance, surface pH, and in vitro drug permeation. The anti-inflammatory activity of LX transdermal patch was determined using two experimental animal designs, one for acute inflammation (rat paw edema) and the other for chronic inflammation (granuloma pouch) on eighty adult albino rats. The results obtained were statistically analyzed. Results: The data showed physicochemical compatibility between the drug and the polymers used. The LX patches (F1, F2, and F3) prepared were uniform thickness, drug content, and the pH of...
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