Posted by admin on Jun 1, 2014 in |
Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in various organs depending upon its dose and the period of treatment. Tridax procumbens has been found to possess various significant medicinal properties. Present study is therefore done to study the histological changes on Kidney of albino rats due to effect of ethanolic extract of Tridax procumbens; orally at a single and daily administration of doses at 300mg/kg b.wt and 600mg/kg b.wt for intervals of 7, 14 and 21days. It is quite obvious that its administration may also affect the cellular organization of vital organs. After treatment period there was alterations occurred in histoarchitecture of kidney and it showed remarkable changes in cortex and medullary...
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Posted by admin on Jun 1, 2014 in |
Objective: To analyse and compare pattern of pre anaesthetic medication use in various surgical specialties. Methodology: Data was collected retrospectively from inpatient records of major surgeries in the Department of Surgery, Orthopaedics, Neurosurgery, Paediatric Surgery, Obstetrics and Gynaecology, Plastic surgery, Urology and Vascular Surgery at M.S. Ramaiah Hospitals, during the period of January 2012 to June 2012. Descriptive analysis was used to analyse the data .SPSS version 19 was used for analysis of data. Results: 752 pre anaesthetic records were analysed, the most frequently used pre anaesthetic medications, in the order of frequency among antianxiety drug is alprazolam (15.6%),followed by midazolam (7.6%),among opioid analgesics fentanyl (5.9%) followed by sufentanyl (0.1%),among antiemetic drugs ondansetron (57.3%),followed by ramosetron (22.8%) and metoclopromide (18.8%) , among gastro protective pantoprazole (74.6%),followed by ranitidine (11.9%), rabeprazole (8.3%),esomeprazole (2.9%) and glycopyrrolate was the only anticholinergic used . Conclusion: Our study gives an insight into the current practice pattern of anaesthetists for pre medication in various surgical specialties in a tertiary care hospital. . It also points...
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Posted by admin on Jun 1, 2014 in |
Street foods are very common sources of infectious diseases in Bangladesh. In present study the microbiological quality of three types of ice-creams obtained from street vendors in Dhaka city was evaluated. The microbiological quality of commercially produced Ice-creams (milk based, lolly and kulfi) was identified by examining total viable count (TVC) and association of enteropathogenic bacteria. The TVC and coliform count were determined respectively on Nutrient and MacConkey Agar after 24 hours incubation at 30̊C. Association of Salmonella, Shigella were detected on SS Agar and Vibrio on Thio-sulfate Citrate Bile Salts (TCBS) media .The average TVC for milk based, lolly and kulfi were 2.53×105 cfu/ml, 7.16×103 cfu/ml and 1.26×107 cfu/ml respectively. A total number of 86 strains were isolated from 3 types of Ice-creams. The association of pathogenic bacteria was the main concern though the TVC was apparently not so high. Besides this, the predominant types of bacteria of the family Enterobacteraceae and vibrionaceae were found (E.g. Plesiomonas, Enterobacter, Escherichia coli, Vibrio spp etc. Salmonella spp were isolated from...
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Posted by admin on Jun 1, 2014 in |
This work aimed to formulate amlodipine besylate Oro flash release films by solvent casting method. Various film forming polymers like Hydroxy propyl methyl cellulose (HPMC) E5, HPMC E15, sodium carboxymethyl cellulose, sodium alginate, xanthan gum were used and out of which HPMCE5 was found to be satisfactory. Propylene glycol was used as plasticizer at a range of 13-32%w/w of the film and 31%w/w was found to be the best concentration based on the flexibility and the strength of the film. Optimized formulation contains HPMC E5 as a film forming agent, propylene glycol as a plasticizer, tween 80 as a surfactant, peppermint oil as flavoring agent and aspartame as sweetening agent. Films were prepared by solvent casting method and found to satisfy the mouth dissolving time and other film parameters. 1.5 x 1.5 cm of film is required to be placed on to patient tongue which gets wet by saliva, rapidly hydrates, adheres to tongue and rapidly disintegrates and dissolves to release the drug for the oro – mucosal absorption...
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Posted by admin on Jun 1, 2014 in |
A protocol was devised for callus induction and in vitro micro propagation of Anisochilus carnosus. Leaf, nodal and immature inflorescence explants were cultured for callusing on solid MS medium with best callusing response achieved at higher concentrations of BAP (12mg/l) alone and in combination with 2,4-D (3mg/l) and IAA (5mg/l). Bud regeneration from inflorescence callus giving maximum (9.67±0.58) shoots per bud was achieved at 12mg/l BAP+5mg/l IAA. Elongated shoots were transferred to half strength MS liquid medium for in vitro rhizogenesis, with best rooting achieved in 2mg/l IBA giving maximum number of 13.00±1.00 roots per shoot. The rooted plantlets were hardened by transferring to polycups containing sterile soil and vermicompost in the ratio of 1:1. After 15 days of hardening, established plantlets were transferred to field with maximum...
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