Posted by admin on Jun 1, 2014 in |
For more than a century Peptic Ulcer Disease (PUD) has been considered to be a major cause of morbidity and mortality. Most first line treatment for PUD involves use of acid suppressing drugs and target against the eradication of Helicobacter pylori (H. pylori) infection. However, the treatment strategy employed in India is not well studied. Hence, this study aims to provide insight into the prescription pattern of drugs used in PUD in India. The data was extracted from the medical records of all patients diagnosed with PUD from June 2011 to May 2012. A retrospective analysis was done to study the prescribing pattern of the drugs. The data was noted down on a pre-designed proforma and analysed. Records of 200 patients were assessed. About 91% of patients were prescribed anti H. pylori kit and the most commonly prescribed kit being Esomeprazole H.P kit (59.7%) followed by Pantoprazole H P kit. Following this, all patients were started on Proton pump inhibitors (PPI) for duration of about 6.89±2.25 weeks. On the...
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Posted by admin on Jun 1, 2014 in |
We studied 90 patients undergoing elective as well as emergency caesarean section under spinal anaesthesia who developed hypotension after subarachnoid block (SAB). They were randomly divided in three groups: Group P Phenylephrine 100µg (n=30), Group E Ephedrine 6mg (n=30) or Group M Mephentermine 6mg (n=30) as IV bolus. Hypotension was defined as decrease in systolic arterial pressure > 20% of baseline values. Elevation of systolic arterial pressure in group P was significantly high for first 6 min of bolus dose as compared to group E and M. There was significant reduction in heart rate in group P. Neonatal Apgar score was >7 in all three...
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Posted by admin on Jun 1, 2014 in |
Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aureus support to cause inflammation in acne. The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. The ethanolic extract of Neem (leaves), Nutmeg (fruit), and Black pepper (fruit) were prepared and formulated into a topical gel. In vitro antibacterial activity was performed against P. acnes, S. epidermidis and S. aureus, using agar well diffusion method. The measured zones of inhibitions of the prepared formulations were compared with standard antibiotic (Clindamycin) and standard marketed topical herbal formulation. The prepared gels were evaluated for pH, viscosity, spreadability, stability, drug content, acute skin irritancy activity and in vitro diffusion. The results from the agar well diffusion showed that Neem,...
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Posted by admin on Jun 1, 2014 in |
In the present study, metronidazole was used for preparing floating dosage forms that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. Hydroxypropyl methylcellulose (HPMC K4M) and Carbopol-934P of different ratio were used to prepare Hydrodynamically Balanced Systems (HBS) by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters and post-compression parameters like hardness, friability, weight variation, uniformity of drug content, percentage swelling, in-vitro floating studies, in-vitro drug release and short term stability studies. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBS formulations showed good in-vitro floating properties with an optimum concentration of gas generating agents; sodium bicarbonate and citric acid. The rate of drug release decreased with increased hardness of tablets. Optimum concentration of HPMC K4M (140 mg) and Carbopol-934P (10 mg) along with excipients was found to...
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Posted by admin on Jun 1, 2014 in |
Evaluation of the anticancer effect of Trapa acornis (Family- Trapaceae) which has long been prescribed for various infectious and malignant diseases. The shells extract of Trapa acornis has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell proliferation assay, cell viability assay and cell cycle analysis. Bio-assays of extracts from Trapa acornis showed that a fraction (fraction 3) from an ethanolic extract had an anticancer effect on SKBR3 and MDA-MB435 human breast cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the plant extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this...
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