Posted by admin on May 1, 2014 in |
The aqueous and methanol extracts of the seeds of Moringa oleifera (Family: Moringaceae) and the seeds of Mormordica charantia (Family: Cucurbitaceae) were screened for their antimicrobial activity against three human pathogenic bacterial strains and three fungal strains by agar-well diffusion assay. The pattern of inhibition varied with the solvent used for extraction and the microorganisms tested. Among these extracts, methanol extract showed significant antimicrobial activity against all the six tested microbes. The most susceptible microorganism was Staphylococcus aureus which showed 8 mm and 7 mm zone of inhibition with methanol extract of M.oleifera and M.charantia respectively. M.oleifera methanol extract was significantly effective against the fungi C.albicans as comparable to the standard flucanozole. Preliminary phytochemical analysis of different extracts revealed the presence of flavonoids, terpenoids and tannins in M.oleifera methanol extract and the presence of alkaloids, glycosides and tannins in M.charantia methanol extract. These compounds may have contributed to their antimicrobial...
Read More
Posted by admin on May 1, 2014 in |
Finding out the alternative uses of the clinically proven and time tested drugs can be one of the best options for drug discovery research. In view of this the present study was carried out to evaluate α-amylase inhibitory activity of the some of the commonly used drugs. The drugs were procured as gift samples from pharmaceutical companies and were evaluated for in-vitro α-amylase inhibitory activity using a colorimetric assay. The results revealed that Buspirone, Amlodipine, Diltiazem, Verapamil, Chlorpheniramine maleate and Cetirizine had prominent α – amylase inhibitory potential in comparison to Acarbose. The drugs exhibiting prominent in-vitro α- amylase inhibitory activities are to be further evaluated in the in-vivo models so that can be used as add – on therapy in diabetes...
Read More
Posted by admin on May 1, 2014 in |
Bryophytes have unique aroma, taste and possess bioactive potential compounds with medicinal properties. Chemical studies of the bryophytes were limited in India due to the small size and expertise in identification of the species. Many of the bryophytes are used as folklore medicine by local tribes. The solvent extracts results poor yield leads to insufficient for testing biological activity. In vitro culture and suitable chemical synthesis was an alternative undertaken to overcome this issue. In the present study, the bioactive phytochemicals of Marchantia linearis and M. polymorphahave been analyzed using GC-MS. The phytochemical composition of the whole thallus ethanol extract was investigated using Perkin-Elmer Gas Chromatography – Mass Spectroscopy. GC-MS analysis of M. linearisand M. polymorphaethanol extracts revealed the presence of the GC-MS chromatogram of the many peaks .The major compounds inM. linearis and M. polymorpha are n-hexadecanoic acid (28.13% and 18.72% respectively) followed by 1,2 benzene dicarboxylic acid (17.63% and 8.93% respectively). The medicinal potentiality of the liverworts may be due to the bioactive compounds present in the...
Read More
Posted by admin on May 1, 2014 in |
Topical gel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. Topical delivery of drugs can be achieved by incorporating drug into the gel matrix for effective delivery of drugs, thus avoiding first pass metabolism and for increased local action in pain management and skin diseases. NSAID’s are non-steroidal drugs having excellent anti-inflammatory and analgesic activity but NSAID’s produces GIT ulceration, liver and kidney trouble especially in case of oral administration. In view of adverse drug reaction associated with oral formulations, many NSAID’s are increasingly administered by topical route. Hydrophilic polymers like Guar gum and Carbopol 940 of varying concentrations were used in an attempt to develop topical hydrogel formulations of diclofenac sodium. Evaluation tests for visual appearance, pH, viscosity, spreadability, assay, in vitro drug release, ex vivo drug release were carried out. In vitro drug release studies were carried out by using USP V dissolution apparatus. The effects of polymer composition...
Read More
Posted by admin on May 1, 2014 in |
Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induced convulsions in rats. MES Model: rats were divided into 4 groups of 6 rats each. GROUP-I (NC) received 2% GA 2ml, GROUP-II (STD) received Phenytoin 25mg/kg, GROUP-III, IV received low dose (300 mg/kg) & high dose (600 mg/kg) of Sapindus laurifolia respectively orallyConvulsions were produced in all groups by giving maximal electric shock of 150 mA for 0.2sec after 1 hour of giving test and standard drugs orally. Tonic clonic seizures were produced after giving electric shock. Recovery time was noted. The percentage of inhibition of convulsions by drugs was measured and compared between the control, standard and test. PTZ model: Rats weredivided and test drugs were given same as above model but...
Read More
