Posted by admin on Jul 1, 2014 in |
Increased production of reactive oxygen species plays important role in pathogenesis of chronic fluoride toxicity resulting from prolonged exposure to fluoride. Oral (NaF) fluoride administration to rats at 20 mg/kg b.w./day for 30 days resulted in elevation in MDA, free amino acid N2, NO level and decreased activities of SOD, GPx, CAT, GR and reduced non enzymatic antioxidant like GSH. Significant alteration in protein and nucleic acid metabolism in discrete brain regions was observed associated with altered activities of proteolytic and transaminase enzymes in treated animals. Neanotis wightiana is traditionally used by local people of Tripura for brain and liver disorders. 3α-hydroxy olean-12-en-27-oic acid isolated from the plant was administered to rats at a dose of 5 mg/kg b.w./day orally for the last 14 days of fluoride exposure in order to elucidate the antioxidative role of this triterpenoid compound in brain protein and nucleic acid metabolism during toxic insult. The present study indicates that the compound appreciably prevented NaF-induced changes in above mentioned parameters in rat brain by antagonizing...
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Posted by admin on Jul 1, 2014 in |
Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The incident of CAD is rising and they are predicted to be the biggest causes of death by 2020 in India. Therefore, the aim of the present study was to assess the association of oxidative stress, antioxidant enzyme and lipid status parameters in CAD patients and to compare the results age- sex matched healthy control in our community. Three hundred participants were enrolled for the present study, with their ages ranging from 40 to 60 years from Era’s Lucknow Medical College & Hospital, Lucknow. Out of which one hundred fifty were clinically new diagnosed case of coronary artery disease like angina pectoris and Myocardial infarction (MI), remaining one hundred fifty were healthy controls. These participants were investigated for serum lipid profile i.e. total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL). High density lipoprotein (HDL) along with blood levels of TBARS and some antioxidant enzyme namely Catalase (CAT), Superoxide dismutase (SOD),...
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Posted by admin on Jul 1, 2014 in |
The purpose of this study was to evaluate the quality of the commonly prescribed imported and locally manufactured antipsychotic drugs (chlorpromazine and thioridazine tablets) that are marketed in drug retail outlets in Ethiopia. Four different sources of Chlorpromazine and two thioridazine tablets were assessed in this investigation. The quality of the samples was examined in seven aspects: percent label amount (assay), weight variation, hardness, percent friability, purity, disintegration time and dissolution rate according to British pharmacopeia (2000) specification. The identity of the tablets was confirmed using FT-IR spectrophotometer. All chlorpromazine and thioridazine samples showed acceptable weight variation as none had percent deviation in weight greater than 5% as stipulated by BP (2000). The mean disintegration times of the products ranged from 4.50 ±0.84 (for chlorpromazine from Cyprus) to more than 60 min (for chlorpromazine Korea). All the tested samples showed active ingredient content with in the acceptable range (from 92.5%-107.5%). Thioridazine 25 mg showed high drug content (107±0.5) and the lowest amount was recorded for chlorpromazine from Cyprus (93.0...
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Posted by admin on Jul 1, 2014 in |
Among various novel drug delivery systems fast dissolving tablets have attracted great attention in recent years due to their ability to release the drug content gradually. Therefore the demand for this dosage form has been increased since last few years especially in patients with swallowing difficulties as this dosage form provides advantage of being swallowed without water. The objective of this research study was to prepare and evaluate fast dissolving tablet of Fexofenadine for acting as a suitable approach to the treatment of allergy together with improved efficacy and reduced dosing frequency. The tablets were prepared by direct compression technique after incorporating superdisintegrants (Ac-di-sol, Sodium starch Glycolate and Crospovidone) in concentrations (1-4%). For preliminary studies twelve (F1-F12) formulations were prepared. Optimization technique was employed to predict the best formulation of all combinations prepared. Pre and Post compression characterization was done on tablets. Then co processed superdisintegrants were used for formulation of tablets showing superior properties. In investigation 32 full factorial design was employed to investigate the combined effect of...
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Posted by admin on Jul 1, 2014 in |
Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersions based on the concept that the drug is dispersed in an inert water-soluble carrier at solid state. Several water soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. Thus the solid dispersion technique can be successfully used for the improvement of dissolution of Fenofibrate. Various solvents, carrier materials, diluents, disintegrating agents, lubricants has been used for the preparation of solid dispersion of fenofibrate. Over the years, a variety of solubilization techniques have been studied and widely used, by many estimates up to 40 per cent of new chemical entities discovered by the pharmaceutical industry today are poorly soluble or lipophilic compounds. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various techniques...
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