Posted by admin on Jun 1, 2014 in |
We studied 90 patients undergoing elective as well as emergency caesarean section under spinal anaesthesia who developed hypotension after subarachnoid block (SAB). They were randomly divided in three groups: Group P Phenylephrine 100µg (n=30), Group E Ephedrine 6mg (n=30) or Group M Mephentermine 6mg (n=30) as IV bolus. Hypotension was defined as decrease in systolic arterial pressure > 20% of baseline values. Elevation of systolic arterial pressure in group P was significantly high for first 6 min of bolus dose as compared to group E and M. There was significant reduction in heart rate in group P. Neonatal Apgar score was >7 in all three...
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Posted by admin on Jun 1, 2014 in |
Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aureus support to cause inflammation in acne. The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. The ethanolic extract of Neem (leaves), Nutmeg (fruit), and Black pepper (fruit) were prepared and formulated into a topical gel. In vitro antibacterial activity was performed against P. acnes, S. epidermidis and S. aureus, using agar well diffusion method. The measured zones of inhibitions of the prepared formulations were compared with standard antibiotic (Clindamycin) and standard marketed topical herbal formulation. The prepared gels were evaluated for pH, viscosity, spreadability, stability, drug content, acute skin irritancy activity and in vitro diffusion. The results from the agar well diffusion showed that Neem,...
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Posted by admin on Jun 1, 2014 in |
In the present study, metronidazole was used for preparing floating dosage forms that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. Hydroxypropyl methylcellulose (HPMC K4M) and Carbopol-934P of different ratio were used to prepare Hydrodynamically Balanced Systems (HBS) by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters and post-compression parameters like hardness, friability, weight variation, uniformity of drug content, percentage swelling, in-vitro floating studies, in-vitro drug release and short term stability studies. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBS formulations showed good in-vitro floating properties with an optimum concentration of gas generating agents; sodium bicarbonate and citric acid. The rate of drug release decreased with increased hardness of tablets. Optimum concentration of HPMC K4M (140 mg) and Carbopol-934P (10 mg) along with excipients was found to...
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Posted by admin on Jun 1, 2014 in |
Evaluation of the anticancer effect of Trapa acornis (Family- Trapaceae) which has long been prescribed for various infectious and malignant diseases. The shells extract of Trapa acornis has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell proliferation assay, cell viability assay and cell cycle analysis. Bio-assays of extracts from Trapa acornis showed that a fraction (fraction 3) from an ethanolic extract had an anticancer effect on SKBR3 and MDA-MB435 human breast cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the plant extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this...
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Posted by admin on Jun 1, 2014 in |
Three Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods was developed for the determination of cefdinir in bulk powder and in pharmaceutical preparation. Method (A) Ratio derivative method(1DD); is used for the determination of intact cefdinir in presence of its degradation product at 307 nm in the range of 2 – 14 µg ml-1 with LOD of 0.049 µg ml-1 and LOQ of 0.162 µg ml-1. Method (B) Ratio difference method ;is based on measuring the difference in the amplitude of intact cefdinir in presence of its degradation product at two different wavelengths ,this is done at 219 nm and 250 nm in the range of 2 – 14 µg ml-1 with LOD of 0.050 µg ml-1 and LOQ of 0.165 µg ml-1. Method (C) First derivative method(1D); is used for the determination of intact cefdinir in presence of its degradation product at 304 nm in the range of 2 – 14 µg ml-1 with LOD of 0.034 µg ml-1 and LOQ of 0.114 µg ml-1. The methods...
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