Posted by admin on May 1, 2014 in |
A new series of thiazolo [3′,2′;1,2] pyrimido [5,4,e] pyrimidines and thiazolo [3′,2′;1,2] [1,2,4] triazolo [3”,4”-c]pyrimido [5,4-e] pyrimidines linked to 2-pyrazolin-5-one moiety were prepared by derivatization of the hydrazine functionality of the heterocyclic hydrazine with various reagents. The newly synthesized compounds were characterized by elemental analyses and spectroscopic techniques. The antimicrobial, anti-inflammatory, and analgesic activities of the synthesized compounds were evaluated using agar diffusion method, carrageenan-induced paw edema, and writhing assays, respectively. The finding of the study showed that, compounds 1a, b, 3a, b, 7b and 15a, b have excellent antimicrobial potency. In the anti-inflammatory activity, compounds 2a and 2b showed remarkable activities (30% and 32%, respectively). For the analgesic activity, the same compounds 2a and 2b gave significant activities (27% and 29%,...
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Posted by admin on May 1, 2014 in |
Rapid expansion of supercritical solution (RESS) has provided a promising alternative to produce ultrafine particles of heat-sensitive materials. Stearic acid is a good lipid for development of solid lipid nanoparticles (SLNs) in drug delivery systems. Therefore, currently, much research on the micronization of stearic acid is going on. In this study, formation of submicron stearic acid was reported by using RESS process. Thanks to high solubility of stearic acid in supercritical CO2, RESS can be used to produce stearic acid nanoparticles and so in this process, extraction temperature and pressure are a bit more than critical point of SC-CO2. The unprocessed and processed stearic acid powders were characterized by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and Fourier transform infrared spectrophotometry (FT-IR). FT-IR analysis and XRD pattern of processed stearic acid showed that the degree of crystallinity was reduced without any chemical structural change. DSC analysis showed a 2.7◦C decrease in the melting point from that of bulk stearic acid. Also, the RESS...
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Posted by admin on May 1, 2014 in |
Citrullus colocynthis is a wild common plant in arid and semi arid areas of Algeria which are characterized by high incidence of scorpion envenomation. It is used in Algeria to treat many diseases. In order to optimize and develop new therapeutic strategies for scorpion envenoming, a phytotherapeutic approach has been investigated. Pharmacological properties of Citrullus colocynthis were evaluated as new approach based on their local and systemic beneficial effects after scorpion envenomation mainly Androctonus australis hector venom (Aah). Local action (paw edema) and systemic effects (inflammatory, metabolic parameters, oxidative stress and hyperglycemia) were studied in pretreated mice with Citrullus colocynthis (50 mg/kg), 30 min before injection of sublethal dose of Aah venom (10 µg/20 g). Obtainedresults showed thatinjected Citrullus colocynthis before envenomation is able to protect animals against the toxicity of the venom. It significantly reduced paw edema, cell migration, exudation, hyperglycemia, and MDA. Citrullus colocynthis decreased also some inflammatory markers (MPO and EPO activities, CRP and C3) and maintain the level of CPK, ASAT and ALAT. Citrullus colocynthis...
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Posted by admin on May 1, 2014 in |
Phthalate esters are industrial chemicals widely used in cosmetics, plastics bottles and medical devices, and the risk of exposure to phthalates is on the increase. In recent years, many studies have been carried out on the possible health hazards of phthalates, including the effect on reproduction. In this studyrats were injected twice weekly with Di-butyl Phthalates (DBP) or Di (2-Ethylhexyl) Phthalates (DEHP) (100 mg/kg) and cohabited with male rats for one month. Fertility and mortality rates as well as fecundity were impacted significantly. Fertility rate decreased from 87 % in control rsats to 67 % in DBP treated and 50 % in DEHP treated rats. Similarly mortality rate in new born litters increased from 2.8 % in control rats to 52.3 % in DBP treated and 31.3 % in DEHP treated rats. Fecundity rate which expresses the average number of litters in each delivery was reduced from 8.2 in control rats to 7.3 in DBP treated and 5.3 in DEHP treated rats. No significant changes were observed in total...
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Posted by admin on May 1, 2014 in |
Probiotic formulations are now widely accepted throughout the world for therapeutic applications as these organisms have a long history of safe use (GRAS). There are two main challenges to make a probiotic formulation viable for commercial utilization. The first one is the quality of health attributes that the probiotic organisms can confer and the second one is the stability of the formulation till the end of its shelf life. With our promising probiotic blend (a mixture of probiotic organisms) as API (Active Pharmaceutical Ingredient), we have tried to develop a sachet containing probiotic formulation by using different types of excipients and packaging options. Among the excipients that were tried, a commercial variety of mannitol was found to be most suitable. Appropriate packaging material is most vital for enhancement of the shelf life of a formulation. Three types of laminates were used for making sachets for protecting the probiotic formulation against moisture and oxygen. Among them, type 1 (combination of Paper/ Polyethylene/Aluminium foil/ Polyethylene) was found to give maximum protection...
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