Posted by admin on Apr 1, 2014 in |
The studies on allergen causing bronchial asthma and allergic rhinitis were done by testing Immunoglobulin E level and absolute Eosinophil count to clinical patients in JEBI laboratory. The patients were from urban and rural areas, comprising both males and females in all age groups. Out of 613 patients, 523 patients were having markedly increased IgE level and 147 patients were found increased Eosinophil count. They were allergic to various allergens, most commonly to dust allergen – 383 patients, to ice cold food – 285 patients, mosquito repellent allergen – 212 patients, climatic condition in 189 patients. Hence, it is well established that modernization, change of food habits, Industrialization and luxurious life style increases the incidents of atopic diseases. There are different tests done to determine allergy and various treatments; but the best way is to slowly eliminate various factors from your life and watch for improvement in...
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Posted by admin on Apr 1, 2014 in |
Wolf berries or Goji berries (Lycium barbarum L. Solanaceae) have a long tradition as food and medicinal plant. The bark of Goji berries is generally harvested in the winter season and then dried to be used for diuretic purposes. Hence, this study was designed to evaluate the possible diuretic effects of powdered L. barbarum. The study was conducted in saline primed Wistar albino rats (n=6) using frusemide (10 mg/kg) as the reference diuretic drug with two oral doses, 250mg/kg/day and 500mg/kg/day, of the test drug. Urine volume and electrolytes (Sodium, Potassium and Chloride) excretion was estimated at the end of 24 hours and data was analyzed by ANOVA followed by Dunnett’s test. P < 0.05 was considered as statistically significant. L. barbarum statistically increased the volume of urine (8.08 ±0.35ml/100g/24hr and 10.05±0.51ml/100gm/24hr) in a dose dependent manner. There was a statistical significant increase in sodium ion excretion (143.17±9.5 m.mol/L at 250mg/kg and 182±8.25 m.mol/L at 500ml/kg) when compared to the normal control (107±2.11 m.mol/L). However, there was a statistically...
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Posted by admin on Apr 1, 2014 in |
Metal complexes having two or more different metal ions not only possess excellent catalytic applications but also have many biological activities. In the present work, some ligand tartarate based mixed transition metal complexes of type [MxMI1-x (C4H4O6)]. XH2O [Where M and MI are Cu and Ni, and x= 0.2, 0.4, 0.6 and 0.8] have been successfully synthesized and were characterized by different sophisticated analytical techniques such as elemental analysis, FT-IR, TGA and XRD. From the analytical data; it was observed that all the complexes exhibited 1:1 (methyl: ligand) ratio. IR data shows that the ligand co-ordinates with metal ions in a bidentate manner through the two oxygen atoms. Thermal analysis shows the degradation pattern of the complexes. The synthesized metal complexes were then tested in vitro for biological activities against Bacillus subtilis, Staphylococcus Aureus, and Escherichia coli to assess their antibacterial and antifungal effect. Some of them showed promising antimicrobial...
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Posted by admin on Apr 1, 2014 in |
The aim of the present study was to characterize solid dispersion (SD) of Candesartan cilexetil (CC) prepared with polyvinyl pyrrolidone K30 (PVP) for enhancing its solubility and bioavailability. The SDs of Candesartan was prepared by solvent evaporation method. The prepared SDs were evaluated for saturation solubility, practical yield, drug content, and in vitro dissolution study, IR-Spectroscopy, X-ray powder diffractometry (XRD) and differential scanning calorimetry (DSC). The dissolution rates of SDs prepared with PVP was much faster than the pure CC and physical mixtures (PM). The data from the XRD showed that drug was crystalline in bulk and in PM. Significant change in melting peak in DSC thermograms of SDs revealed amorphization. SDs showed marked increase in the solubility of CC with increasing carrier concentration. At the highest ratio of carriers the drug solubility was enhanced about 6-folds for SD in PVP. The dissolution rate was increased with increasing carrier concentration at pH 6.5. XRD data revealed a remarkable interaction between the CC and the carrier that enhanced drug dissolution....
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Posted by admin on Apr 1, 2014 in |
Skin has to bear various external traumas like wounds, burns, blisters, irritation etc. as well as topical diseases like psoriasis, vitilago, cancer and herpes. Various drug delivery systems like vesicles, microspheres, transdermal patches, nanoemulsions, microemulsions, microsponges etc. are available which are better than conventional drug delivery methods because these bypass systemic circulation as well as drug can be targeted directly to the required site. Microsponges are tiny sponge-like spherical particles with a large porous surface and provide controlled release. Herpes simplex is a viral disease occurring in two forms Herpes labialis and Herpes keratitis which occur on lips and epidermal layer of skin respectively. Conventional formulations used for treating herpes have various drawbacks like irritation, rashes, frequency of dosing and low bioavailability. Hence microsponge loaded topical preparations herbal gel and medicated lipstick of Acyclovir was prepared with a purpose to overcome these drawbacks. Microsponge loaded controlled release formulations of Acyclovir were prepared using quasi emulsion solvent diffusion method. The proposed formulations of Acyclovir loaded microsponges were characterized for particle...
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