Posted by admin on Mar 1, 2014 in |
The pet ether and chloroform extracts of Durenta repens leaves was screened for antidepressant action in tail suspension model. Both the extracts showed antidepressant action at the dose of 200mg/kg. Chloroform extract produced significant (p<0.001) mobilisation of the animals when compared with that of the standard drug Imipramine (10mg/kg) and acts as a potent centrally acting antidepressant drug. Results obtained for pet ether extract was not significant in treating the depression in the animal model. The antidepressant action may be mediated by the centrally releasing catecholamine’s possesses antidepressant...
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Posted by admin on Mar 1, 2014 in |
Herbal medicines are gaining more and more attention all over the world, due to their long historical clinical usage and comparatively less side effects. Standardization of herbal drugs and their quality control is needed with proper integration of modern scientific techniques and traditional knowledge. The analysis and quality control of herbal medicines are moving towards an integrative and comprehensive direction, in order to better address the inherent holistic nature of herbal medicines. The techniques used in standardization of plant material include its morphological, anatomical and biochemical characteristics. The present study highlights the pharmacognostical studies including parameters such as powder analysis by microscopical evaluation, and study of physicochemical parameters i.e. proximate analysis and preliminary phytochemical screening of seed kernel of Caesalpinia bonducella Linn. and fruits and roots of Coccinia indica Wight & Arn. which are used as antidiabetic agents. The present study, thus, will help to provide important information with respect to the proper identification of the plant for utilization in different herbal...
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Posted by admin on Mar 1, 2014 in |
The main aim of the extended release tablets is to reduce the dose frequency and to improve the patient compliance. The objective of the present study was to formulate and optimize the extended release tablets of Pramipexole dihydrochloride monohydrate for 24hrs, which made the advantage of this formulation as once daily with more patient compliance. The combination of different hydrophilic polymers and hydrophobic polymer in varying concentrations were used to get the desired extended release profile over a period of 24 h. The drug and excipients mixed granules was subjected to evaluate the physical properties like angle of repose, bulk density, compressibility index were found to be satisfactory. The hydrophilic polymer Hydroxy propyl methyl cellulose (HPMC K200M) at 41.7% and( HPMC E 3LV) at 5% in combination with hydrophobic polymer (Eudragit L100) at 5% level produced desired extended release Pramipexole dihydrochloride monohydrate matrix tablets. The in vitro drug release of optimized formulation (F9) was 99% and was more release than innovator product of Mirapex ER (94.5%) which extended up...
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Posted by admin on Mar 1, 2014 in |
Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It is not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods-: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patients admitted in the wards of medicine department at Sir Sayajirao General (SSG) Hospital, Vadodara. The data was collected by using case record form specially prepared for the study. Results: In our study, total 350 prescriptions containing 539 antimicrobial drugs were prescribed in-patients during study period. Average number of antimicrobials per prescription was 1.54.486 (90.16%) and 53(9.53%) antimicrobials were prescribed by using generic name and trade name respectively. 313(58.07%) and 226(41.93%) antimicrobial agents were prescribed for parenteral administration as well as oral route respectively.188(53.71%) prescriptions constitute single antimicrobial agents, while 162(46.28%) prescriptions contain either two or more than two antimicrobial agents. Among all prescriptions, 4 % and 20% of them were without the age and...
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Posted by admin on Mar 1, 2014 in |
Antihypertensive agents are class of drugs that are used to treat hypertension (high blood pressure) as well as other CVS disorders. Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. Single-dose combination antihypertensive therapy is an important option that combines efficacy of blood pressure reduction and a low side effect profile with convenient once-daily dosing to enhance compliance as compared to monotherapy. The survey enabled to monitor 500 prescriptions and found most available combinations at Savar area in Bangladesh among which beta blockers with Ca-channel blockers was used most (89%) and the brand Fixocard of Incepta was the brand...
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