Posted by admin on May 1, 2014 in |
The study was designed to determine the phytocomponents and in-vitro anthelmintic activity of chloroform fraction of methanolic extract of Antigonon leptopus leaves. GC-MS analysis of chloroform fraction of the methanolic extract of Antigonon leptopuswas performed on a GC–MS equipment (Thermo Scientific Co. Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II). The extract under study has been screened for anthelmintic activity on Pheretima posthuma. The chloroform fraction was analysed by GC-MS which revealed the presence of many diversified compounds including phenols, hydrocarbons, quinazolines, coumarins, steroids and terpenes like cadinene, juniper camphor etc. All the compounds were identified from Wiley spectral library. Mass spectral data of 16 compounds is presented. The results obtained from the study indicate significant anthelmintic activity, supporting folk use of the plant when compared with the standard. From the results, it is evident that Antigonon leptopus contains various bioactive compounds and biological activity which is recommended as a plant of phytopharmaceutical...
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Posted by admin on May 1, 2014 in |
Some transitional metal ions complexes with 3-{[(Z)-(4-hydroxyphenyl) methylidene] amino} benzoic acid with general formula [M(L2)xH2O], [where M = Mn(II),Co(II), Ni(II),Cu(II), Zn(II), Pd(II) and Pt(II)metal ions and L=3-{[(E)-(4-fluorophenyl) methylidene] amino} benzoic acid ] have been synthesized and characterized on the basis of elemental analysis, conductance, magnetic susceptibility, IR, UV-Visible, ESR, X-RD and TGA/DTA. The complexes are covalent in nature with octahedral geometry. The covalency factor (β), bonding parameter were calculated. The dentistry of the complexes was in the range between 1.5 to 1.90 m/dm3 in toluene and the spectral line indicates low crystallinityof the complexes. All the complexes are non-electrolytic in nature. All the complexes are paramagnetic in nature expect Zn(II) complexes indicates slight participation of the 3d electron in bond formation. The ligand and its complexes have been screened for their antimicrobial activity with some bacteria it shows that antibacterial and antifungal activity complexes are more active towards these bacteria than Schiff...
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Posted by admin on May 1, 2014 in |
Hypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL) was evaluated in experimental rat models in vivo. The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effects of POL extract with doses 200mg, 400mg and 800mg were evaluated on Wistar albino rats by using a standard protocol. Anti-hyperglycaemic effect of POL extract with the same doses i.e. 200mg, 400mg and 800 mg were also studied in alloxan induced diabetic albino rats. The aqueous POL extract at doses 800mg showed significant hypoglycaemic effects as compared with a standard drug like glibenclamide. The same doses of POL also showed anti-hyperglycaemic properties in alloxan induced diabetic rats. The present study showed that the aqueous POL extract has hypoglycaemic as well as anti-hyperglycaemic...
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Posted by admin on May 1, 2014 in |
The aim of the present study is to develop a nanoparticle formulation as a potential carrier for topical drug delivery. Colchicine loaded Nanoparticles (Colchicine-NPs) were prepared by the double emulsion solvent evaporation method using biodegradable and non biodegradable polymers alone or as binary mixtures. Based on the evaluation of the entrapment efficiency, the particle size and the % drug released over 24 hours, a polymer mixture of poly-D,L-lactic acid (PLA), and Eudragit RL, in the weight ratio 1:1 was selected for further studies. The following formulation variables were optimized: the pH of the external aqueous phase was adjusted to a value of pH 6 in order to decrease the solubility of colchicines; the solvent composed of dichloromethane and acetone 1:1 (v/v) was selected to obtain maximum water miscibility; CaCl2 was selected as a counter ion additive in the external aqueous phase; Span was used in the internal organic phase to increase entrapment efficiency and medium chain triglyceride was found to be most efficient at a concentration of 30% w/w....
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Posted by admin on May 1, 2014 in |
As Antioxidant potential of many plants is mainly due to phenolic components such as phenolic acid, phenolic diterpense therefore total phenolic content and antioxidant potential of cucurbita maxima. (Pumpkin) powder was determined respectively by using Folin-Ciocalteu reagent and diphenyl-picryl-hydrazyl (DPPH) assay. In this method the antioxidants present in the plant extracts reacted with DPPH, which is a stable free radical and converted it to 1,1-diphenyl-1,2-picryl, hydrazine. Total phenolic content of pumpkin was determined using Folin-Ciocalteu reagent and gallic acid as standard, amount of phenolic compound was found to be 6.5 mg/gm powder of the drug. The high fiber content of pumpkin helps to aid proper digestion and in traditional medicine it is used as an anthelmintic, taenicide, diuretics and in the treatment of hemorrhoids so we compared the anti oxidant potential of pumpkin powder with marketed preparation (Pilex tablet). The half maximal inhibitory concentration (IC50) is a measure of the effectiveness of a compound in inhibiting biological or biochemical function. IC50 value of pilex tablet = 8.53 µg/ml & IC50 value...
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