Posted by admin on Apr 1, 2014 in |
The aim of the present study was to characterize solid dispersion (SD) of Candesartan cilexetil (CC) prepared with polyvinyl pyrrolidone K30 (PVP) for enhancing its solubility and bioavailability. The SDs of Candesartan was prepared by solvent evaporation method. The prepared SDs were evaluated for saturation solubility, practical yield, drug content, and in vitro dissolution study, IR-Spectroscopy, X-ray powder diffractometry (XRD) and differential scanning calorimetry (DSC). The dissolution rates of SDs prepared with PVP was much faster than the pure CC and physical mixtures (PM). The data from the XRD showed that drug was crystalline in bulk and in PM. Significant change in melting peak in DSC thermograms of SDs revealed amorphization. SDs showed marked increase in the solubility of CC with increasing carrier concentration. At the highest ratio of carriers the drug solubility was enhanced about 6-folds for SD in PVP. The dissolution rate was increased with increasing carrier concentration at pH 6.5. XRD data revealed a remarkable interaction between the CC and the carrier that enhanced drug dissolution....
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Posted by admin on Apr 1, 2014 in |
Skin has to bear various external traumas like wounds, burns, blisters, irritation etc. as well as topical diseases like psoriasis, vitilago, cancer and herpes. Various drug delivery systems like vesicles, microspheres, transdermal patches, nanoemulsions, microemulsions, microsponges etc. are available which are better than conventional drug delivery methods because these bypass systemic circulation as well as drug can be targeted directly to the required site. Microsponges are tiny sponge-like spherical particles with a large porous surface and provide controlled release. Herpes simplex is a viral disease occurring in two forms Herpes labialis and Herpes keratitis which occur on lips and epidermal layer of skin respectively. Conventional formulations used for treating herpes have various drawbacks like irritation, rashes, frequency of dosing and low bioavailability. Hence microsponge loaded topical preparations herbal gel and medicated lipstick of Acyclovir was prepared with a purpose to overcome these drawbacks. Microsponge loaded controlled release formulations of Acyclovir were prepared using quasi emulsion solvent diffusion method. The proposed formulations of Acyclovir loaded microsponges were characterized for particle...
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Posted by admin on Apr 1, 2014 in |
A rapid and sensitive method for the determination of the best conditions that allow us to calibrate the ibuprofen in drug is presented. This approach uses high performance liquid chromatography with DAD detector, which is a separation method most used because it is fast, easy, and maintains the nature of the mixture to be separated. The spectra of ibuprofen were recorded using several mobile phases “58%Na2HPO4 (50mmol/l), 42%ACN” and “60%ACN, 40% water “when the pH values are (pH=2.5 and pH=5); the flow rate values are 0.9ml/min -1.5 ml/min with detection wavelength of 240nm; and two stationary phases using the C18 column and Phenyl urea column (25cm x 4.6mm, 0.5µm). The ibuprofen sample: 1 mg of ibuprofen dissolved in 1 mL of water. For this we have tried through our study aiming relying on foreign...
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Posted by admin on Apr 1, 2014 in |
Zopiclone (ZPC), a cyclopyrrolone derivative, is a short-acting hypnotic agent. Its pharmacological properties include hypnotic, sedative, anxiolytic, anticonvulsant and muscle-relaxant actions. ZPC has a single chiral centre, and its enantiomers are S-zopiclone (S-ZPC) and R-zopiclone (R-ZPC). S-ZPC was adjudge to possess two- fold enhanced pharmacological activity than racemate (ZPC) while its opposite enantiomer R-ZPC appears to have almost zero activity and elevated toxicity. A high performance LC-MS\MS method employing positive electrospray ionization was developed for the simultaneous determination of both S-ZPC and R-ZPC in human plasma samples by using S-Zopiclone d8 as internal standard. Analytes were extracted from plasma samples by employing solid phase extraction technique. After extraction, 5µL of clean sample was injected on to chromatographic system and distinct separation achieved on chiralpak IC-3, 0.46 cm I.D*15 cm L column with the isocratic mobile phase consisting of a mixture of Ammonia in Acetonitrile and Milli Q Water. Detection was performed using API 4000 MS that monitors specific transition per compound in Multi Reaction monitoring mode. Limit of quantitation...
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Posted by admin on Apr 1, 2014 in |
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 receptor. Protein- Ligand interaction plays a major role in structure-based drug designing. In this study, analogs of BMS-378806 drug for HIV target protein gp120 were virtually designed using Marvin Sketch 4.1.10 and molecular docking studies were carried out using HEX 4.1 docking software. From the results, it was observed that, analog-6 showed better binding affinity to gp120 with Etotal = -102.67 than the original BMS-378806 drug, thus indicating that this compound might be considered as a potential drug candidate against gp120 for controlling HIV-1 infection. Further studies need to be carried out to evaluate the pharmacological efficacy of these...
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