Posted by admin on Jan 31, 2024 in |
The ideal of the exploration is to formulate hydrogel containing nanosponges of Triamcinolone acetonide for the treatment of Psoriasis. Psoriasis is presently treated with a numerous of topical and systemic remedies. Numerous of these treatments, still, are costly and involve adverse effects, similar as immunosuppression. As a result, there is a need to develop curatives that are effective, have less adverse effects, and are less costly. With the use of solvent emulsion diffusion process triamcinolone acetonide nanosponges were formulated, in which Eudragit L-100 was used as polymer, polyvinyl alcohol was used as an emulsifying agent, and an organic solvent mixture of Dichloromethane was used to make nanosponges. For the preparation of optimized batches of Hydrogel containing nanosponges various gelling agents were used such as Carbopol 934, HPMC K4, Sodium alginate and Acacia with same concentration. Therefore, with the help of different analytical tests i.e., SEM, FT-IR, Zeta potential etc. It was confirmed that by using the nanosponges formulation the biopharmaceutical characteristics of triamcinolone acetonide increased which is a BCS...
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Posted by admin on Jan 31, 2024 in |
Crocus sativusvar. ‘cashmerianus’ (Iridaceae)is worldwide known as “Saffron” contains than volatile and aroma-containing compounds mainly terpenes, terpene alcohol, and their esters. The bitter taste and a hay-like fragrance of saffron are due to presence picrocrocin and safranal. Traditional anxiolytic and antidepressant effects of C. sativus var. ‘cashmerianus’ was evaluated using successive extracts in elevated plus maze test and forced swim test in rat sat doses level of50, 100 and 200 mg/kg/p.o., where as diazepam (1mg/kg) was used as standard drugs. Successive methanol and aqueous extracts of petals of C. sativus at a dose of 200 mg/kg/p.o. (1st, 3rd and 7th day) were shows significant (*P <0.05) as like diazepam increased the percentage of time spent and arm entries in the open arms and decreased the closed arms entries and duration in closed arm in elevated plus maze. The results for antidepressant activity using forced swim test shown that the ethyl acetate, methanol and aqueous extracts of petals of C. sativus var. cashmerianus at a dose of 200 mg/kg significantly...
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Posted by admin on Jan 31, 2024 in |
Background: The most important factor contributing to human genetic problems is chromosomal abnormalities. It is crucial to choose screening tests and diagnostic procedures that are exact, accurate, safe, and able to be conducted during early pregnancy in order to make the best-informed choice possible while taking into account the probable outcomes of pregnancy. Method and Material: In the present prospective study chromosomal analysis was done for various types of suspected 900 referred patients. The patients were referred from mainly Gynaecology hospital Usha Nursing Home and Sat Kaival Hospital, Anand in association with Gene Care Accuris Laboratory, Surat from June 2021 to March 2023. Result: The overall frequency of chromosomal abnormalities was 2.5% (23/900). Out of 23 cytogenetic abnormal patients, numerical abnormalities were found in 21(2.33%) and structural abnormalities we detected in 02(0.22%) patients. The most common autosomal abnormalities were Down’ syndrome 18(2%). Another abnormality was Edward’s Syndrome 03(0.33%). Chromosomal structural disorder occupied 02(0.22%) including robertsonian translocation. Conclusion: To avoid the delivery of foetuses with chromosomal disorders, karyotype screening of...
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Posted by admin on Jan 31, 2024 in |
The purpose of this current investigation was for screening the wound healing potential of Ethanolic extract of Caralluma adscendens (EECA) whole plant. Caralluma adscendens (Apocynaceae), a common medicinal plant in traditional Indian medicine. Mentions in folk medicine and existing data raised an outlook on this plant for evaluating wound healing potential. Ethanolic extract of Caralluma adscendens (EECA) has been examined for its wound healing activity by utilizing couple of wound models in rats: (i) excision wound model and (ii) incision wound model following application of standard or extract topically. Animals have been categorized into 4 groups with six in every group. Group I left untreated, Group II received soframycin skin cream as standard, Group III and IV received 100mg and 200mg of Ethanolic extract of Caralluma adscendens (EECA) whole plant. Results obtained upon treatment with the plant extract groups shown activity close to standard drug activity, Soframycin, in terms of wound contraction ability, time taken for wound closure and tensile strength. 200mg of plant extract has produced better wound...
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Posted by admin on Jan 31, 2024 in |
The pyrimidine scaffold found in many bioactive drugs; some commercially available drugs containing at least one pyrimidine ring in their structure. The literature survey reveals that replacement of 1H-pyrazole of pyrazolo [3,4-d] pyrimidine ring system by other bioactive moieties drastically alters its pharmacological properties. Prompted by the varied biological activities of pyrazolopyrimidine derivatives, we envisioned our approach towards the synthesis and antimicrobial screening of a novel series of pyrazolo [3,4-d] pyrimidine derivatives. Novel functionalized pyrimidine derivatives and their derived bicyclic pyrazolo thiazolo pyrimidine compounds were synthesized by cyclocondensation of 3-cyano-2- methylthio-4-oxo-4H-substituted thiazolo [1,2-a] pyrimidines with hydrazine hydrate gave novel series of pyrimidine derivatives in one step, and the chemical structures of the compounds was confirmed by IR and 1 H NMR spectral data. All the compounds of the series have been screened for their antibacterial and antifungal activity studies. The result revealed that all compounds showed significant antimicrobial activity. The current research is being directed towards the synthesis and improvement of biological activity of the pyrazolopyrimidine...
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