Posted by admin on Apr 1, 2014 in |
The present investigation concerns the design and evaluation of floating tablets of Tizanidine hydrochloride, which after oral administration are designed to prolong the gastric residence time and increased drug bioavailability. It is a centrally acting α2 adrenergic agonist. It is used in the treatment of migraine headaches, spasms and anticonvulsant. The dosage was designed by using natural polymers, Guar gum, Xanthan gum, Karaya gum, Psyllium and HPMC. Floating tablets prepared by direct compression technique. The prepared floating tablets were evaluated in terms of their precompression parameters, friability, hardness, uniformity of weight, drug content, swelling index, in-vitro dissolution studies. The floating properties and drug release studies were determined using 0.1N HCl as a dissolution medium. The best formulation was determined based on the buoyancy and drug release...
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Posted by admin on Apr 1, 2014 in |
Organ weight analysis is an important endpoint for identification of potentially harmful effects of test compounds in toxicology studies. Organ weight differences are often accompanied by differences in body weights between treatment groups which make the organ weight interpretation more difficult. We have evaluated the relationship between organ weight and body/brain weight based on statistical analysis to determine which endpoint (absolute organ weight, organ-to-body weight ratio, or organ-to-brain weight ratio) is likely to accurately detect target organ toxicity by using data from control rats that were part of 43 toxicity studies conducted under similar conditions. All the organs weight data of both sexes were subjected to the linear regression; correlation was established with body weight and brain weight. Present data set revealed that there was a strong correlation between liver, kidneys and heart weights with body weights. Organs like spleen and adrenal weight also showed correlation with body weight. Other commonly weighed organs in toxicity studies viz. thymus, pituitary and thyroid- parathyroid did not show consistent pattern of relationship...
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Posted by admin on Apr 1, 2014 in |
The antitumor activity of the methanol stem extract of Mimosa rubicaulis lam (MEMR) was evaluatedagainst Ehrlich Ascites Carcinoma (EAC) tumor model in Swiss albino mice. After 24h of intraperitonial inoculation of tumor (EAC) cells in mice, MEMRwas administered at the dose of 100, 200 and 400mg per kg body weight orally for 13 consecutive days. After 24 h of the last dose and followed by eighteen hours of fasting, mice were sacrificed and antitumor effect of MEMR extract on EAC bearing mice was assessed by evaluating tumor volume, viable and nonviable tumor cell count, mean survival time, percentage of increase in life span and hematological parameters of EAC bearing host. MEMR showed significant (p< 0.0001) decrease in tumor volume, viable cell count, percentage of increase in life span of EAC bearing mice. Haematological profile such as RBC, WBC, Haemoglobin, PCV (packed cell volume) levels restored to more or less normal level in MEMR treated mice as compared to EAC control. Effect of MEMR on viability of cancer cell lines...
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Posted by admin on Apr 1, 2014 in |
The present study was conducted to evaluate the hepato-protective activity of methanol extract of seeds of Trigonella foenum graecum (TFG)in CCl4 induced toxicity in Wistar albino rats. Seeds of TFG were collected, and subjected to continuous cold maceration in a macerator, for 72 h with solvents like petroleum ether (60 – 80) and methanol separately. Hepatic injury in rats was induced separately by administration of equal mixture of CCl4 and olive oil (50% v/v, 1.25 ml/kg, i.p.). Liver damaged was monitored by raised biochemical marker enzymes (SGOT, SGPT, and alkaline phosphatase). CCl4 was administered twice a week, on every first and fourth day of all 14 days. The extract at the dose of 250 mg/kg b. wt. was evaluated by inducing hepatotoxicity with CCl4 and using silymarin (100 mg/kg) as the reference standard. Biochemical parameters like, SGOT, SGPT and serum bilirubin level were analysed. A section of liver was subjected to histopathological studies. Based on the above studies, it is reported that the methanol extract of TFG possess significant...
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Posted by admin on Apr 1, 2014 in |
The objective of the present work was to formulate and evaluate a sustained release gastroretentive dosage form. A mucoadhesive bilayered film was prepared consisting of an Immediate Release (IR) and a Controlled Release (CR) layer. The film is folded into a Hard Gelatin Capsule which after administration into GIT unfolds and adheres to the GI mucosa. Cefpodoxime Proxetil is an antibiotic of BCS Class IV. Thus by retaining the drug in the gastric region its absorption is enhanced. Hence it is taken as the model drug. Different polymers like HPMC, EC and Carbopol were used for the film preparation and the mucoadhesive property was evaluated which showed that Presence of Carbopol increases the films mucoadhesive property. The in vitro drug release, bio-adhesion and mechanical property of the batches were evaluated to get the best batch. The optimization study of the film was carried out applying 32 factorial design. The final batch is subjected to In vivo gastroretention test on rabbits which showed a gastric adherence for...
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