Posted by admin on Jan 1, 2014 in |
Objective: To evaluate the hypoglycemic activity of ethanolic extracts, of Convolvulus pluricaulis in normal and streptozocin-induced diabetic rats. Materials and Methods: Ethanolic extract of leaves of C. pluricaulis were orally tested at the dose of 400 mg/kg, 600 mg/kg & 800 mg/kg for hypoglycemic effect in normal and streptozocin-induced diabetic rats. In addition, changes in body weight, serum cholesterol, triglyceride and total protein levels, assessed in the ethanol extract-treated diabetic rats, were compared with diabetic control and normal animals. Results: 800 mg/kg of C. pluricaulis produced a significant reduction in fasting blood glucose levels in the normal and streptozocin-induced diabetic rats. Apart from 400 mg/kg, 600 mg/kg showed activity from day 14. Significant differences were observed in serum lipid profiles (cholesterol and triglyceride), serum protein, and changes in body weight by 800 mg/kg treated-diabetic animals, when compared with the diabetic control and normal animals. Conclusion: 800 mg/kg of C. pluricaulis exhibited significant antihyperglycemic activity in normal and streptozocin-induced diabetic rats. They also showed improvement in parameters like body weight...
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Posted by admin on Jan 1, 2014 in |
The purpose of this research was to develop mouth dissolve tablets of Hydrochlorothiazide and Ramipril, were prepared by direct compression technique. Ramipril is an Angiotensin Converting Enzyme (ACE) inhibitor. It is an inactive prodrug that is converted to ramiprilat in the liver, the main site of activation, and kidneys. Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Sodium and Chlorine (Na+ and Cl-) reabsorption from the distal convoluted tubules in the kidneys. The tablets were prepared using microcrystalline cellulose and dicalcium phosphate as diluents along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and Maize Starch. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. Formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F4) was found to be acceptable according to standard...
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Posted by admin on Jan 1, 2014 in |
Fluoride (F) is highly electronegative anion with cumulative toxic effects, from prolonged ingestion that can lead to the pathogenesis known as fluorosis, a condition especially persistent in third world countries, where populations have little choice as to the main source of F-contaminated drinking. In recent times many neurological problems among children are being addressed in endemic areas. Thereby reasons for the neurotoxicity have to be explicated thoroughly. In this study premated Wistar albino rats were exposed to 50 and 150 ppm fluoride in drinking water during gestation and pups born to them were used to analyze the extent of neurotoxicity imposed in discrete brain areas. Dose dependent toxicity was evident in different brain regions and fluoride exposure has significantly enhanced the levels of malondialdehyde (P>0.05), glutathione (P>0.05) and decreased the activities of superoxide dismutase (P>0.05), catalase (P>0.05), glutathione peroxidase (P>0.05) and glutathione- S-transferase (P>0.05). Alterations were region specific and oral supplementation of dietary antioxidants viz., vitamin-C (20mg), vitamin-E (400mg), zinc (200mg) and selenium (40mg) not only inhibited oxidative stress...
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Posted by admin on Jan 1, 2014 in |
A novel, precise, accurate, rapid and cost effective isocratic reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the estimation of Arterolane maleate and Piperaquine phosphate in pharmaceutical dosage forms (tablet). The drugs were estimated using hypersil C18 (250 mm x 4.6 mm i.d- 5 µm particle size) column. A mobile phase composed of phosphate buffer, acetonitrile, methanol in proportion of 40:30:30 v/v, at a flow rate of 1.0 ml/min was used for the separation. Detection was carried out at 244 nm. The linearity range obtained was 20-70 µg/ml for ART and 100-350 µg/ml for PIP with retention times (Rt) of 3.353 min and 2.389 min for ART and PIP respectively. The correlation coefficient values were found to be 0.999. Precession studies showed % RSD values less than 2 % for both the drugs in all the selected concentrations. The percentage recoveries of ART and PIP were in the range of 99.47-100.72% and 99.30-100.18% respectively. The assay results of ART and PIP were 99.57% and...
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Posted by admin on Jan 1, 2014 in |
Spirulina is an algae used in our country for people living with HIV (PLHIV) and it is known especially for its therapeutic immunostimulatory effects. Spirulina capsules produced locally enriched in zinc and selenium called “spiruline plus” were formulated and given to PLHIV. The objectives of this randomized placebo controlled trial were to assess the tolerance by reporting side effects and to evaluate the clinical and biological outcome of patients after 12 months follow-up. A randomized clinical trial comparing four groups of patients infected with HIV type 1 (HIV-1) and treated with different diets was conducted over 23 months. These groups were: a first group of patients treated only with placebo, a second group treated with “spiruline plus”, a third group treated with antiretroviral (ART) and placebo, the fourth group treated with ARTs and “Spiruline plus”. Clinical and laboratory data were collected at baseline and at 3, 6, 9 and 12 months after inclusion. Some of the side effects reported in the group receiving antiretroviral therapy and “spiruline plus” decreased...
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