Posted by admin on Apr 1, 2014 in |
Tridax procumbens (Linn.) is an important medicinal plant belonging to the family Asteraceae. It is known for a number of pharmacological activities like antidiabetic, anticancer, anti-inflammatory, wound healing, hepatoprotective and antioxidant activity.Flavonoid “Quercetin” was isolated from the flowers of this plant. Dried flowers were Soxhlet with petroleum ether, chloroform, and methanol successively. The methanolic fraction so obtained was successively extracted with petroleum ether, diethyl ether and ethyl acetate. The ethyl acetate fraction was hydrolyzed with 7% H2SO4 and extracted with ethyl acetate to obtain crude Quercetin. The crude product was recrystallized with dilute ethanol to get pure Quercetin. The purified material was subjected to various chromatographic and spectral techniques such as UV, IR, HPTLC, HPLC, NMR etc. and was identified as “Quercetin”. This study is also of practical importance because quercetin is an important constituent of Tridax procumbens and it has many uses such as in cancer, diabetes, inflammation, & in viral infections...
Read More
Posted by admin on Apr 1, 2014 in |
The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5.0 blank fed state simulated intestinal fluid and & pH 6.5 blank fasted state simulated intestinal fluid. Hence, tartaric acid is selected in the core tablet to enhance the dissolution of clopidogrel tablets at intestinal fluid pH 5.0 & pH 6.5. Formulation was evaluated with different levels of tartaric acid in core tablet. Formulation with 50mg/unit of tartaric acid showed the extent of dissolution of 100% in pH 5.0 blank fed state simulated intestinal fluid and 96% in pH 6.5 blank fasted state simulated intestinal fluid. To control the impact of humidity on degradation, a moisture protective layer is coated on core tablet with non-aqueous solvent, using conventional coating pan....
Read More
Posted by admin on Apr 1, 2014 in |
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950’s and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and ethanol solvents to obtain the respective extracts. In the present study, we have investigated the role of aqueous and ethanol extracts of Parthenium hysterophorus against milk-induced leukocytosis and eosinophilia in albino mice. The results of the study revealed that pretreatment with both the extracts caused significant reduction in the total leukocyte and eosinophil counts in animals in dose-dependent manner. From these results, it can be concluded that the plant Parthenium hysterophorus is having antieosinophilic...
Read More
Posted by admin on Apr 1, 2014 in |
The therapeutic use of herbal medicine has gained considerable momentum in the world during the past decade. Hence, Quality control standards for various medicinal plants used in indigenous systems of medicine are becoming more necessary. Adulteration and misidentification of medicinal plants can cause serious health problems to consumers and pose legal problems for pharmaceutical firms. So, the aim of this investigation was to establish a simple and efficient protocol to determine possible drug adulteration by use of similar plants. Powder microscopy can help the correct identification and establish standardization of plant drugs. The present study has revealed an easy way to identify Alpinia calcarata and Alpinia galanga microscopically and thus it can also be employed to detect the degree of adulteration in powdered raw medicinal plant materials as well. Likewise, microscopical detection is easy, reliable and cost effective tool for detection of adulteration in medicinal plants.Alpinia calcarata Rosc. and Alpinia galanga Linn. of Zingiberaceae popularly known also as Lesser galangal and greater galangal, have a widespread occurrence in India,...
Read More
Posted by admin on Apr 1, 2014 in |
The present work was designed to formulate floating tablet of Metoprolol Succinate with synthetic superdisintegrant as swelling agent. Various formulations of Metoprolol Succinate were prepared by direct compression method using the different concentrations of superdisintegrant ranging from 10% to 15%. The selected batches were evaluated for various parameter like weight variation, thickness, diameter, friability, floating lag time, duration of floating, water uptake, content uniformity, in-vitro drug release and in-vitro drug release kinetics. Formulations with Crosspovidone had showed better results than the Kyron T-314. The data obtained from the in-vitro dissolution studies of optimized batch F5 was fitted in different models viz. zero order, first order, Korsemeyer-Peppas model, Higuchi model and Hixon-Crowell model. Drug release mechanism was found to be First order from optimized formulation. Further for getting the type of release mechanism the data was fitted as per the Korsemeyer-Peppas equation. The exponent value n was found in between 0.45 to 0.89. It indicates that the release of Metoprolol Succinate from developed floating tablets followed non-Fickian transport...
Read More
