Posted by admin on May 1, 2014 in |
Ficus carica is the common fig fruit belonging to the family Moraceae, The Pharmacognostical studies of the half ripened fruits were carried out using the various micro-chemical tests. The dried fruits were subjected to extraction using 90 % ethanol and this extract was further evaluated for the adaptogenic activity. Swim Endurance test in mice and Cold Stress model in rats was used to screen the antistress potential. Biochemical parameters such as Blood Glucose level, Total Leukocyte count, Total Cholesterol, HDL, LDL, Triglyceride levels were estimated. The microscopic studies confirmed that the fruit of Ficus is a modified receptacle of the inflorescence; this contains the male and the female flowers which are situated in the interior of the receptacle. The ethanolic extract was found to increase the swim endurance time significantly. In case of cold stress model the ethanolic extract increased the depleted blood glucose and lowered the elevated total cholesterol as well as triglyceride levels. It was able to maintain the normal homeostasis as well as act as an...
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Posted by admin on May 1, 2014 in |
Purpose: To extract, isolate and identify daidzein from the bark of Acacia Arabica (Lam.) Willd of Bhopal, Madhya Pradesh, India. Methods: Succesesive methanolic extract from the bark of Acacia arabica was subjected to column chromatography and fractionated by benzene, n-butanol, and acetone successively. Eluents having similar Rf values were pooled together. These pools were subjected to flavonoid test and only a single pool passed it which was again subjected to chromatographic separation for purification and crystallized powders was subjected to UV, FT-IR, EI-MS and 1H-NMR for structure identification. Results: We have successfully isolated and identified daidzein by comparing with previously published literatures. Conclusion:From this study it can be concluded that the whole plant can be used as a source of...
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Posted by admin on May 1, 2014 in |
The phytochemical screening, the antihyperglycemic and antihyperlipidemic effects of crude hydroalcoholic extract of aerial parts ofMarrubium vulgare L. were evaluated in normal and Streptozotocin- induced diabetic in Wistar rats. First, the preliminary phytochemical test to identify the chemical constituents of crude hydroalcoholic extract of aerial parts of M. vulgare was carried. Next, the rats were treated with a single intraperitoneal injection dose of 300 mg/kg body weight. The changes in fasting blood glucose level were measured, in the short term, before (0, 60, 120 and 180min) after the treatments. After 14 days experimental period, rats were weighed and blood was collected for measurement of serum glucose, total cholesterol, and triglycerides. The phytochemical investigation of M. vulgare led to the characterization of several families of secondary metabolites: flavonoids, coumarins, saponins, tannins, terpenes and/or sterols. The statistical data indicated the very significant (p<0.0001) decrease in the fasting blood glucose, total cholesterol and triglycerides, for diabetic rats, 2 weeks after injection of extract studied, compared to control diabetic rat. This decrease is...
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Posted by admin on May 1, 2014 in |
The purpose of this study was to develop prednisolone-loaded microsponges for colon specific drug delivery. The microsponges formulations were prepared by quasi-emulsion solvent diffusion method employing eudragit RS 100 as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. Afterwards, microsponge formulations were prepared by gradually increasing the drug: polymer ratio. The surface morphology, particle size, production yield, and drug entrapment efficiency of microsponges were examined. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. Particle size of prepared microsponges was observed in the range of 465 ± 12.5 to 82.2 ± 15 µm. The drug entrapment efficiency of the microsponges was found in the range of 53.38 ± 0.95 to 91.75 ± 1.60 %. The in-vitro dissolution studies of microsponges in the media with different pH (1.2, 7.4 and 6.8) showed that drug release in colon could be controlled by Eudragit RS 100. It was observed that the release kinetics on the basis of the...
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Posted by admin on May 1, 2014 in |
The antiulcer activity of Aqueous and Methanolic extracts of Neolamarckia cadamba leaves and bark was investigated in Pylorus ligation and Aspirin induced ulcer models in Wistar albino rats. In both models the common parameter determined was ulcer index. Aqueous extract of Neolamarckia cadamba leaves (AENCL) at dose of 200mg/kg and 400 mg/kg produced significant inhibition of gastric lesion induced by Pylorus ligation induced ulcer and Aspirin induced gastric ulcer. The AENCL (200mg/kg and 400mg/kg) showed significant (p<0.05) reduction in gastric volume, pH, free acidity, Total acidity, ulcer index and % ulcer inhibition was compared to control. This present study indicates that AENCL and Methanolic extract of Neolamarckia cadamba leaf (MENCL) have potential antiulcer activity in both models. These results may further suggest that the AENCL and MENCL possess antiulcerogenic as well as ulcer healing properties which might be due to its antisecretory activity. Antioxidant activity was evaluated for free radical scavenging activity by DPPH assay which showed the significant antioxidant activity of AENCL and MENCL further supported their antiulcerogenic...
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