Posted by admin on Dec 1, 2013 in |
Curcumin, a hydrophobic polyphenolic compound derived from the rhizome of the herb Curcuma longa, possesses a wide range of biological applications including anti-cancer. Nanocurcumin particles were prepared by top-down method as its can improve hydrophilic and increase bioavailability. As a result, curcumin concentration was yielded up to 10% (w/w), and the particle size was defined less than 1,000 nm in diameter. The particles were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic laser light scattering (DLS), and X-ray diffraction (XRD). The acute oral toxicity was done with a dose up to 500 mg per kg of body weight and no dead mice were found indicating the nanocurcumin particles are safe for long-term use. The model of hepatic fibrosis mice was induced by intraperitoneal (i.p) injection of 0.8 mL of carbon tetrachloride (CCl4) in olive oil (1:3 v/v) per kg of body weight. Nanocurcumin particles (15 mg/kg of body weight) were orally administered to hepatic fibrosismouse model in 4 weeks to evaluate the therapeutic potential in comparison...
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Posted by admin on Dec 1, 2013 in |
The Piper betel is an evergreen and perennial creeper belonging to the Piperaceae family, with glossy heart-shaped leaves and white catkin. It is valued both as a mild stimulant and for its medicinal properties. The total phenolic content of methanolic leaves extract was estimated by Folin-Ciocalteu assay method, and was found to be 0.110 mg/CE/g (Catechine Equivalent per gram). However, antioxidant activity of methanolic leaves extract of Piper betel was determined by DPPH free radical scavenging method. The DPPH radical scavenging activity of methanolic extract of Piper betel was found to be highest at 100μl concentration which was 25.2%. Nevertheless, % DPPH scavenging activity of standard ascorbic acid at same concentration was found to be 40%. The % DPPH scavenging activity increases with the increasing concentration. The concentration of Piper betel needed for 50% inhibition (IC50) was found to be 282.31μg/ml whereas 369.19 μg/ml needed for ascorbic...
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Posted by admin on Dec 1, 2013 in |
A high-performance liquid chromatography (HPLC) method has been developed for the determination of isosorbide mononitrate and its related substances in isosorbide mononitrate and sodium chloride injection. An C18 column (5μm, 250 ×4.6 mm) was used for the determination, with methanol and water (25:75,v/v)as the mobile phase at the flow rate of 1 mL min−1. The detection wavelength was 210 nm. The related substances were quantitated versus an external standard. The method was capable of resolving all of the two known related substances. The two related substances were isosorbide dinitrate (ISDN) and 2- isosorbide mononitrate (2-ISMN), respectively. The method was successfully applied to quantify related substances. The limits of detection of isosorbide mononitrate, isosorbide dinitrate and 2-isosorbide mononitrate (2-ISMN) were all 0.3ng. And the limits of quantitation of isosorbide mononitrate, isosorbide dinitrate and 2- isosorbide mononitrate (2-ISMN) were all 0.8ng. The method was found to be accurate, precise, specific, linear and sensitive, for the...
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Posted by admin on Dec 1, 2013 in |
The investigation on the local knowledge about traditional herbal medicine is becoming increasingly important in defining strategies and actions for conservation of medicinal plants. This study therefore considered worthwhile to collect information from local rural and tribal population living in Betul district of Madhya Pradesh (India) concerning the use of medicinal plants; identify the most important species used; determine the relative importance of the species surveyed and calculate the informant consensus factor (ICF) in relation to medicinal plant use. Data collection relied predominantly on qualitative tools to record the interviewee’s personal information and topics related to the medicinal use of specific plants. The present study revealed that 119 plant species grown in the study region are in use by rural and tribal community in traditional medicine for the treatment of various diseases. Most of the locals interviewed dealt with well-known safe medicinal plants such as, Allium sativum, Acacia arabica, Emblica offficinalis, Momordica charantia and Ocimum sanctum with use value of 0.62, 0.54, 0.52, 0.51, and 0.50 respectively. Dental, inflammation-pain...
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Posted by admin on Dec 1, 2013 in |
Depression is a well-defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easily annoyed and disinclined to rest. It is a very important public health problem which is devastating millions of life all over world and making the scenario very look very pathetic. Homoeopathic medicines are effective in the treatment of various acute and chronic diseases. Efficacy of homoeopathic medicines on depression is of great importance. Most mental health disorders like depression, anxiety tend to chronic illness that requires long-term treatment. Appropriate treatment of depression with homoeopathic remedies can help to prevent the likelihood of serious recurrences of depression. The advantages of homeopathic remedies are-it is effective in people of all age right from children to the elderly, is safe and has minimal...
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