Posted by admin on Nov 1, 2013 in |
The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system which is considered to be stable, robust quality and enhanced dissolution rate. To optimize the method of manufacture by formulate the Ciprofloxacin solid dispersion system by various techniques like Physical mixing, Co-grinding, Kneading and solvent evaporation techniques. The disintegrating agent used in the present study is Crosscarmellose sodium. Among the four different techniques used for preparation of solid dispersions solvent evaporation technique has shown the increase in dissolution rate that is the Trail-5 was found to have a faster solubility and dissolution property which was prepared by using Crosscarmellose sodium as a disintegrant in the ratio of...
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Posted by admin on Nov 1, 2013 in |
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent is primary determinant for its activity. To serve this purpose, we have decided to substitute arylacetamide with benzotriazole which may exploit the analgesic potential of newly synthesized derivatives i.e N-(Alkyl or Aryl)-2-(1H-benzotriazol-1-yl)-acetamides and thus it may be helpful in reducing the pain without having side effect of...
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Posted by admin on Nov 1, 2013 in |
The aim of present work is to develop and validate simple, sensitive, economical and accurate Spectrophotometric methodhas been developed for determination of Maraviroc in pure form and in pharmaceutical formulations. Maraviroc in Phosphate buffer pH 7.4 shows maximum absorbance at 210 nm. Beer’s law was obeyed in the concentration range of 5-25 µg/mL, The LOD and LOQ were found to be 0.10428 μg/ml and 0.315 μg/ml respectively. A recovery of Maraviroc in tablet formulation was observed in the range of 100.70-103.90%. Percentages assay of Maraviroc in tablet was more than 99.73%. The proposed method is precise simple, accurate, precise, economical and robust and can be used for routine analysis of Maraviroc in bulk and pharmaceutical...
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Posted by admin on Nov 1, 2013 in |
The present study was carried out to assess the pharmacokinetic drug interaction between nebivolol and cefixime following single oral dose administration in hypertensive patients. Therapeutic dose of nebivolol alone and combination with cefixime were administered to a separate group of hypertensive patients. Serial blood samples were collected at pre-dose (0.0) to 48 h post-dose following each treatment to characterize the pharmacokinetic parameters. The plasma nebivolol concentrations were estimated by a sensitive liquid chromatographic mass spectrometry (LC-MS) method. Mean (SD) of AUC0-t (ng.h/mL) and AUC0–∞ (ng.h/mL) for nebivolol given as a combination versus nebivolol alone is 39.24 (6.96) vs. 17.29 (4.60) and 45.30 (6.70) vs. 24.42 (5.08) respectively. Corresponding values for Cmax (ng/mL) is 2.98 (0.47) vs. 3.09 (0.37). Cefixime significantly increased the extent of exposure of nebivolol when used in combination. There was minor change in the peak exposure and elimination parameters. The results indicate that there observed to be a pharmacokinetic interaction when nebivolol is administered in combination with cefixime. Hence, the combination is contraindicated or used with...
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Posted by admin on Nov 1, 2013 in |
The aim of the work is to formulate sustained release matrix tablets of simvastatin and to optimize them using Response Surface Methodology. The tablets were prepared by direct compression method and evaluated as per pharmacopoeia methodology. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile. Concentration of HPMC K15M (X1) and PVP K30 (X2) were taken as the independent variables and the in vitro dissolution (Y1), t50% (Y2) and mean dissolution time (Y3) as dependent variables. Response surface plots and contour plots were drawn, and the optimum formulations were selected by feasibility and grid searches. Both the polymers had a significant effect on drug release from the tablets. The formulations were followed Higuchi drug kinetics and diffusion was the prime mechanism of drug release. The polynomial mathematical models produce for various response variables using the regression analysis and were found to be statistically significant (P< 0.05). Optimization study was validated using 8 confirmatory runs, indicated very high degree of...
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