Posted by admin on Oct 1, 2013 in |
The present research exertion was undertaken to evaluate the antiarthritic effect of methanolic extract of Moringa oleifera Lam stem bark. The extract was subjected to preliminary phytochemical investigation and antiarthritic activity was evaluated with turpentine oil, formaldehyde and CFA induced arthritis. Other parameter like body weight and hematological estimation were carried out.The result indicated that the methanolic extract of Moringa oleifera has excellent antiarthritic activity against turpentine oil, formaldehyde and CFA induced arthritis. The all groups of animals showed increase in the body weight except arthritis control and hematological perturbations indued by CFA were maintained. The complete result indicated that Moringa oleifera methanolic extract possesses a potent protective effect against turpentine oil, formaldehyde and CFA induced arthritis. The consequences of the present investigation proved well thatMoringa oleifera methanolic extract is effective in the treatment of rheumatoid arthritis and that it support the common belief prevailing in traditional medicine world...
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Posted by admin on Oct 1, 2013 in |
Research in complementary therapies and alternative medicines is increasing and formulating therapeutic medicines based on these findings has become the need of the hour. The present research aims to formulate and evaluate a polyherbal gel containing Achyranthes aspera and Plectranthus amboenicusextract. The formulation was designed by using alcoholic as well as aqueous extract of Achyranthes aspera and Plectranthus amboenicus leaves in varied concentrations. The extracts were subjected to various physicochemical evaluations. The gel was prepared by using a suitable gelling agent- Carbopol 934. The polyherbal formulation was evaluated for its antifungal activity and it was found that the formulation have elicited promising antifungal activity which was comparable with that of standard drug (fluconazole). However the activity was found to be due to the synergestic blend of herbal drugs. The polyherbal formulation exhibits a promising topical gel for fungal infections of the skin. Thus the present study demonstrates an immense scope for development of such polyherbal formulations and also explores the vast potential to further carry out research by exploiting...
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Posted by admin on Oct 1, 2013 in |
A simple, precise, accurate and reproducible spectrophotometric method has been developed for Simultaneous estimation of Atenolol and Nifedipine by employing second order UV derivative Spectrophotometric method in Water: ACN (60:40). The Second order derivative absorption at 245.63 nm (zero cross point of Nifedipine) was used for quantification of Atenolol and 218.7 nm (zero cross point of Atenolol) for quantification of Nifedipine. The linearity was established over the concentration range of 50-150 μg/ml and 20-60 μg/ml for Atenolol and Nifedipine with correlation coefficient (r2) of 0.999 and 0.998 respectively. Interday and intraday studies showed repeatability of the method. The mean % recoveries were found to be in the range of 99.25% – 101.15% and 98.56% – 101.85% for Atenolol and Nifedipine, respectively. The method is successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study. The proposed method has been validated as per ICH guideline and successfully applied to the simultaneous estimation of Atenolol (ATN) and Nifedipine (NIF) in their combined Tablet dosage form....
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Posted by admin on Oct 1, 2013 in |
The purpose of the study was to present the know-how of preparing intramuscular injection forms of chlorpromazine HCl (CPZ) solutions for use in veterinary medicine. Aqueous solutions of CPZ were prepared aseptically at concentrations of 10 or 25 mg/ml. The CPZ formulations were intended for veterinary use only. The concentrations of CPZ in the solutions were 1 or 2.5% which were formulated mainly with ascorbic acid, benzyl alcohol, sodium chloride, sodium metabisulfite or sodium sulfite and water for injection. The pH values of the solutions were adjusted by HCl or NaOH to be in the range of 5 to 6 before filtration (pore size of 0.2 µm), sterilization and distribution into air tight containers. The aqueous formulations of CPZ were clear, almost colorless to slightly straw-colored solutions, sterile and free from undesirable visible particlulate matters. They were according to the requirements of solutions intended for intramuscular injection. Using the prepared formulations, the acute toxicity (median lethal dose, LD50) of CPZ was close to that of a commercial product. Similarly,...
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Posted by admin on Oct 1, 2013 in |
According to Brazilian regulation, the registration of phytomedicines must inform the characterisation of, at least, one of their constituent. In order to contribute to this goal, a tincture of Cissus verticillata (L.) Nicolson & C.E. Jarvis prepared with ethanol 96oGL was investigated. This plant species is widely used due its hypoglycaemic properties, to control diabetes, and empirically to treat the consequence of cerebral vascular accident. Thus, this work reports the evaluation of the flavonoid content in the tincture and the characterisation of flavonoid glycosides, because flavonoids can be part of the active constituents of this herbal drug, and also because these substances can be used as markers. This article both confirms the presence of several flavonoids previously detected in this herbal drug and reports the presence of others not previously described and are characterised in this species for the first time. The flavonoid content in the tincture, determined as Rutin using UV spectroscopy, is 3.6g% of tincture. A method based on reversed phase (RP) HPLC analysis was developed and...
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