Posted by admin on Sep 1, 2013 in |
The present study involves in the preparation and evaluation of floating tablets of Salbutamol sulphate by direct compression method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose, Dextrin and Carbopol. Sodium bicarbonate, Tartaric acid and citric acid were incorporated as gas generating agent. The study aims to achieve different formulations using different polymers in order to find out the most suitable and successful type of polymer. The prepared tablets were evaluated in terms of thickness, average weight, hardness, friability, drug content uniformity, swelling index, in- vitro buoyancy study and in-vitro dissolution study. The formulated tablet Hardness was found to being the range of 2.6 to 3.8 kg/cm2, the % friability was in the range of 0.30 to 0.50. The Swelling Index and floating time of different formulations range from 1.78 to 16.15 and 8.15 to 12 hrs respectively. In-vitro release studies were carried out using USP XXII dissolution test apparatus. The tablet containing Salbutamol sulphate was released from batch F1-F10 found...
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Posted by admin on Sep 1, 2013 in |
Demand of the Unani herbal drugs is becoming universal as the people are becoming more and more cognisant about the natural benefits of medicines with plant origin. Herbal drugs being easily affordable are becoming the first preference for the common man over purchasing the expensive modern pharmaceuticals. The WHO estimates that 80% of the world population rely on the medicines of plant origin for their primary healthcare. Even though the market for the herbal drugs is increasing with time but the chances of substitution and adulteration have become a major menace to these natural products. In the present study Habb-e-Azaraqi, which is used in the Unani medicine from last several decades for the various ailments of the human body has been evaluated for the various parameters of standardization for the development of its quality standard. The parameters include ash value, moisture content, swelling index, extractive value and quantitative study of various biologically important constituents like phenolic compounds, flavonoids, alkaloids, etc. The study might provide practical information regarding its identification...
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Posted by admin on Sep 1, 2013 in |
The purpose of the study is to evaluate the antimicrobial and cytotoxic activity of methanolic and pet-ether extract of leaves of Mesua ferrea. The antimicrobial activity was investigated against eight pathogenic Gram-positive and Gram-negative bacterial species at three concentrations (100, 300, 500 µg/disc) by using disc diffusion method. Both extracts showed moderate antibacterial activity against six bacterial species among eight and the activity was increased with increasing concentration of the sample. The maximum antimicrobial potential was obtained against Bacillus subtilis, Bacillus megaterium and Staphylococcus aureus in case of both extracts. The cytotoxic effect of the extracts was assayed on Artemica salina leaches. The LC50 values were found to be 7.94 μg/mL for methanolic extract and 3.98 μg/mL for pet-ether extract compared to 0.451 μg/mL for standard drug vincristine sulphate. The study confirms that the plant extracts have moderate antimicrobial activity and considerable amount of cytotoxic...
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Posted by admin on Sep 1, 2013 in |
The study was carried out to evaluate the immunomodulatory activity and the effect on the biochemical parameters of Averon®, an herbal formulation, on cyclophosphamide induced immunosuppression in rats. Haematological and biochemical parameters were evaluated after 21 days on blood samples collected by retro-orbital puncture at sacrifice. Results showed that death occurred in the immunosuppressed groups before collection of blood by retro-orbital puncture whereas in the immunoprophylactic groups, there was a minimal dose-boosting effect of the white blood cells that was statistically significant. There was no significant statistical difference in alkaline phosphatase, total bilirubin, cholesterol, high density lipoproteins, low density lipoproteins, triglycerides and total proteins (p≤0.05). However, a statistical significant difference was seen in the alanine aminotransferase and creatinine levels (p≤0.05) and aspartate aminotransferase (p≤0.001). Averon® is thus said to be better suited as an immunoprophylactic herbal formulation than immunostimulatory with better immunoboosting effects at higher doses (>400mg/kg) in the order of 800mg/kg and...
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Posted by admin on Sep 1, 2013 in |
Marine organisms possess an inexhaustible source of useful chemical substances for the development of new drugs. The present project focused to identify the bioactive compounds from the seaweed Kappaphycus alvarezii. The experimental samples were collected from the sea coast of Rameshwaram, Tamil Nadu, in the form of fresh living sample. The fresh solvent extracts of K. alvarezii were found to be rich in total carotenoid content and vitamin C. The concentration of vitamin C was found to be 9.2 mg/g.f.wt, Polyphenol 27.2mg GAE standard, gallic acid equivalent/100 g.dry.wt, β-carotene 6.52 mg/g dry.wt and total carotenoid 0.769 mg/g.f.wt. The phytochemical analysis demonstrated the presence of high carbohydrate, protein, alkaloids, glycosides, flavonoids, steroid, and phenolic compound and absence of tannin in the extracts also k. alvarezii extracts revealed macromolecules contents such as carbohydrate contents of 53 g, Protein 16.2g and fat content 1.01 g /100 g of dry wt. Micronutrients were estimated that calcium content was 5.3g/100g and iron content was found to be more in 1.14 mg, phosphorus content of...
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