Posted by admin on Feb 1, 2014 in |
The percentage error observed in the claimed standard concentration of cholesterol 200 mg/dl for kits A to D is found to be 0.6, 12.3, 8.96 and 3.76 respectively. As per the guidelines of CLIA 8 allowable error is +10% for cholesterol estimation. Similarly as per the NCEP 9 guidelines + 9 % error is allowable. Therefore, it is noted that kit A is the best kit with an error of just 0.6% followed by kit D which showed an error of 3.76%. Kit C is the third best kit which had an error of 9%. However, kit B failed to meet the CLIA and NCEP requirements as it exhibited an error as high as 12.3%. This highlights that artificial standards provided by the kit manufacturers with reagents cannot be relied upon as a calibrator system, since at the very beginning of calibration the system would fail, as observed in case of kit B in this...
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Posted by admin on Feb 1, 2014 in |
Adverse drug reactions (ADR) contribute significantly in health care cost through increased patient morbidity and mortality. Thus, there is an urgent need to create awareness among health care professionals towards ADR monitoring and reporting. The aim of our study is to assess the knowledge, attitude and belief of physicians and pharmacists towards ADR. This is a prospective cross-sectional survey based study. Questionnaire consists of 17 open ended and closed ended questions, was prepared and validated for its content and circulated to physicians and pharmacists from the selected hospitals and community pharmacies of Ras Al Khaimah, U.A.E. Majority of the physicians (n=50) were not aware of the ADR reporting system in UAE. Good number (n=19) of physicians did not know whom to report. The most common classes of medications associated with ADR were antibiotics. Great part of the physicians (n=45) have mentioned that only around 10% of their patients report their ADR. Only small number (n=15) of these physicians have reported the ADR to head of department or to drug...
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Posted by admin on Feb 1, 2014 in |
The toxicity profile of alcoholic extract of roots ofTragia cannabina Family: Euphorbiaceae was studied in wistar rats. The multiple oral administration of extract at single dose of 100, 500, 1000, 2000 and 3000 mg/kg body weight for 24 hrs. did not produce sign of toxicity, behavioral appearance, change on a gross appearance. The sun-acute toxicity was determined by administration of graded dosage (125, 250, and 500 mg/kg body weight; orally) of the extract daily for 28 days and the effect on body weight, organ weight and serum biochemical parameters were estimate. Body weight of dose and control rat increase throughout the duration of treatment. Our data demonstrate significantly no difference in serum concentration of aspartae amino transferase, alanine amino transferase, alkaline phosphate, protein, urea, creatinin were measured. The results showed that subacute treatment did not shows any change in corporal weight and hematological parameters. However, a change in liver weight but not in hepatic enzymes was observed. This suggests that the liver function is not altered by Tragia cannabina...
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Posted by admin on Feb 1, 2014 in |
The effects of 4-thiazolidinone-derivative – Les-589 as perspective anti-hypoxic agent under the experimental hypoxic hypoxia actions were studied. The values of peripheral blood and hematological indexes as well as parameters of cellular oxidative metabolism (level of lipoperoxidation products, activity superoxide dismutase and catalase, levels and ratio of lactic and pyruvic acids in the blood and liver tissue) of the experimental animals were investigated. The presented data confirm the anti-hypoxic properties of the Les-589 under study conditions and are the strong argument for further Les-589 study as perspective antihypoxant with preventative...
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Posted by admin on Feb 1, 2014 in |
The present study was performed with an objective to assess knowledge, awareness, frequency indication and pattern of uses and attitude towards Non-Steroidal anti-inflammatory drugs (NSAIDs) among the scholars. In this survey based qualitative research, 591 respondents from the C.S.J.M. University campus, Kanpur, were screened out during the changing weather of north India (January–February 2013) with the help of Questionnaire. All the respondents were having the experience of pain- 61.08% headache, 31.64% backache, 21.31% joint pain, 16.36% menstrual pain, 13.19% sport or exercise related pain; and as analgesic the aspirin and paracetamol with or without ibuprofen were found to be most commonly used drugs among 63.75% NSAIDs user as pain reliving remedy. 51.6% had taken drug multiple times in a day while 28.93% of them took multiple doses at a time. 53.3% of scholars were unaware about such irrational pattern and adverse effects of these NSAIDs, although they were pursuing higher studies. While 46.7% scholars, who were aware about some of the ADRs of NSAIDs were belonging to pharmacy (78.61%)...
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