Posted by admin on Sep 1, 2013 in |
The present study was an attempt to investigate the feasibility of the matrix based sustained release unit dosage formulation of cefixime trihydrate. Matrix tablets were prepared by using xanthan gum along with the other polymer combinations (Guar gum, sodium alginate and hydroxypropylmethyl cellulose). Effect of different formulation variables like polymer concentration, ratio of polymer combination and compression force was evaluated. The Fourier transform infrared spectroscopy,differential scanning calorimeter and X ray diffraction analysis were also carried out to evaluate physico-chemical compatibility between drug and excipients. In vitro release results suggested a 24 h controlled drug release from the prepared tablet of cefixime trihydrate. Swelling and erosion studies were performed to verify the release mechanisms involved in the formulation. In vitro antimicrobial study was also performed to check the synergistic efficacy of CFT with excipients. The formulations were found to be stable up to 3 months of stability testing at 40ºC/75%...
Read More
Posted by admin on Sep 1, 2013 in |
Oral bioavailability of Simvastatin is very low (5%) due to bad solubility and effect of first pass. The aim of this work is to enhance its solubility and reformulating it as orodispersible tablet to overcome the two problems. Simvastatin solid dispersions in β- cyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios namely 1:1, 1:2, and 1:3 by kneading and solvent evaporation methods. Solid dispersion formation and mixture compatibility was investigated by DSC and FTIR. Based on the results of solubility studies; the best solid dispersion formula was selected and formulated into orodispersible tablet using Emcosoy, K-polacrillin as novel superdisintegrants and mannitol, Pullulan as water soluble diluents and evaluated. The results showed that the increase in drug solubility was dependent on polymer type, concentration and also was affected by preparation method. Simvastatin-hydroxyl-butyl-β-cyclodextrin solid dispersion mixture prepared in 1:2 drug: polymer ratio by solvent evaporation method had a higher solubility. Orodispersible tablet formula prepared by Emcosoy as superdisintegrant, Pullulan as diluent showed least wetting and disintegration times (20...
Read More
Posted by admin on Sep 1, 2013 in |
In present work, a new vanishing cream using a natural base from palm oil and palm kernel oil and standard vanishing cream using stearic acid were prepared. The creams were o/w emulsions containing suitable combination of oil phase and aqueous phase along with preservatives. Both creams were white, non-greasy and smooth on application. They were subjected to various parameters such as; pH, viscosity, spreadability and tube extrudability. Stability studies of the prepared creams were determined at different temperatures for a period of 3 months as per ICH guidelines and the results revealed that both formulations were with good stability except the standard vanishing cream which was slightly hardened at 5oC. The pH was found to be 6.7 and 6.98, and spreadability was found to be 11.30g. cm/sec and 13.33g.cm/sec for natural base and stearic acid based creams respectively. The tube extrudability was found to be good and fair for natural base and stearic acid based cream respectively. Furthermore, the formulations were studied for primary skin irritation test on rabbits...
Read More
Posted by admin on Aug 1, 2013 in |
Use of plants as a source of traditional healing systems around the world that utilize herbal remedies is an important source for the discovery of new antimicrobials against resistant strains of bacteria. It is being used as a source of medicinal agents for antibacterial, antihelminthic, astringent, emetic, sedative and stimulant. A 10 g dried leaves powder of Woodfordia fruticosa was extracted separately in each different solvent i.e., aqueous, ethanol and methanol. The extract was stored at 4ºC in airtightbottles until further uses. Total 8 strains including gram positive and gram negative bacteria were selected to assess the susceptibility test against the different drug extract. These are Escherichia coli (ATCC-25922), Pseudomonas aeroginosa (ATCC-27853), Salmonella paratyphi (ATCC-9150), Salmonella typhimorium (ATCC-25241), Shigella sonnei (ATCC-25931), klebseilla pneumonia (ATCC-27736), Staphylococcus aureus (ATCC-25923) and Proteus vulgaris (ATCC-6380). The antibacterial activity was performed in vitro using Agar well diffusion assay and diameter of zone of inhibition was measured. The Methanolic shows good zone of inhibition in almost bacteria. The highest zone of inhibition was observed in...
Read More
Posted by admin on Aug 1, 2013 in |
The rapid and sensitive UV spectrophotometric method was described for the determination of etodolac, non-steroidal anti-inflammatory drugs. The type of solvent, the range of wavelength and the range of concentration were chosen in order to optimize the conditions. The developed and validated method was successfully applied to the analysis of etodolac without derivatization with any compound in commercial formulations. The standard calibration curve of etodolac was constructed by plotting absorbance versus concentration in the determined concentration range with the final dilution. The calibration curve was Absorbance in 277 nm wavelength = 0.0303 Concentration in ppm –0.0201 and linear (R³0.9995) in concentration range of 1-50 ppm of etodolac. The LOD and LOQ values of method were 0.7 ppm and 1.0 ppm, respectively. Moreover, the proposed method was fast with respect to analysis time as compared to more sophisticated chromatographic...
Read More
