Posted by admin on Dec 1, 2013 in |
Celastrus paniculatus is an important medicinal plant used in India. Traditionally seed oil of this herb is used widely in several medicinal preparations and its bark is used in malaria in folk medicines. It is endangered and vulnerable plant. The investigation used Reducing power assay and Total phenolic content to determine antioxidant potential in the ethanolic extract of the drug. The result showed significant reducing power activity and good phenolic content ability of the sample. The extract of leaves may be considered as good antioxidant...
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Posted by admin on Dec 1, 2013 in |
An analytical method has been developed for quantitative determination of diltiazem, chemically (+)-cis-1,5-benzothiazepin-4-(5H)one, 3-(acetyloxy)-5-[2-(dimethyl amino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydro chloride, by complexation with Pd(II) spectrophotometrically. Diltiazem is a calcium channel blocker type antihypertensive drug. Diltiazem forms an stable orange colored 1:2 complex with Palladium(II) Chloride with lmax 400nm, molar absorptivity coefficient of complex e= 8.5 X102 l mol-1cm-1, Beer’s law range 3.413 X101 mg/ml to 2.722 X102 mg/ml with intercept of regression 0.019 and correlation coefficient 0.989. Interference of foreign metal ions and effect of temperature and pH was also studied. The characterization of complex involves, Elemental Analysis, FTIR, 1H NMR, ESR, Raman spectra, magnetic susceptibility measurement and thermal studies. On the basis of above studies structure of the complex has been proposed. The developed analytical method was applied on in-vivo blood samples- whole blood and serum samples. For whole blood samples Beer’s law range is 1.01 X 102 mg/ml to 2.77 X 102 mg/ml with coefficient of variance ±1.49 and relative standard deviation 0.64% and for serum samples Beer’s law range is...
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Posted by admin on Dec 1, 2013 in |
The title compounds (7a-f), (8a-f) and (9a-f) have been prepared from chalcones (6a-f) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles (7a-f) and cyanopyridines (8a-f) respectively. Chalcones (6a-f) on condensation with 2-amino thiophenol in the presence of glacial acetic acid give benzothiazepines (9a-f). Structures of newly synthesised compounds were established on the basis of their elemental analysis, IR and 1H NMR. All the synthesised compounds have been screened for their antimicrobial...
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Posted by admin on Dec 1, 2013 in |
The purpose of this study was to produce of microparticles for Dry Powder Inhalation, produced by environmentally driven Amphiphilic crystallization technique process by using different nonionic surfactants at different concentration and at different processing parameters, for inhalation therapy. Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of asthma by pulmonary delivery.The objective of the current work was to developed microcrystals by using Amphiphilic crystallization process with different nonionic surfactants at different processing parameters. Salvation of Budesonide in aqueous Cremophor EL and Tween 20(1:1) was investigated using HPLC. A response surface type central composite design were employed using Design-Expert 5.0 software (StatEase, QD Consulting, Penzance, UK) with the factors investigated were stirrer speed, antisolvent addition rate, Cremophor EL and Tween 20. The crystals were filtered and freeze dried.Optimize the process variables for narrow particle size distribution (PSD). Cremophor EL and Tween 20 were added as the stabilizers. Freeze dried crystals were subjected to XRD, DSC and SEM analysis for stability. The PSD also depended on...
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Posted by admin on Nov 1, 2013 in |
Histopathological changes in developing stomach caused by lead acetate exposure at different days of the postnatal development were investigated in Swiss mice. In this study, pregnant Swiss mice were exposed to 533 mg/kg BW of lead acetate from 10th day of gestation to 21st day of lactation. The pups of exposed groups were sacrificed at 1, 7, 14 and 21 day of lactation period, and the effects of lead on histopathology of developing stomach were observed. Results of the present study showed that administration of lead to pregnant mice caused histopathological change in the stomach of developing pups. It is concluded that lead adversely affects the normal histology of developing stomach in pups exposed during gestation and lactation but it could not delay the major events of postnatal...
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