Posted by admin on Aug 1, 2013 in |
Air pollution tolerance index was assessed with plant species located at ChinnaTirupathi, Salem, Tamil Nadu, India. This study was conducted during March, 2013. Since, all the lands are converted to buildings, it is essential to know more about plants and its benefits offered to the environment and the dangers, risks caused by cutting trees. In this study, our aim is to evaluate, whether the plant is toleranant or sensitive to pollution. From the results obtained, we can infer that all the plants collected were having APTI value in the range of 9.41 to 15.46. Selected plants having APTI score of less than 16 are grouped under plants sensitive to pollution and are biological indicators of air pollution. Sensitivity of certain plants to air pollutants is variable from place to...
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Posted by admin on Aug 1, 2013 in |
Nanoparticles of silver (Ag-NPs) have received tremendous research attention for their widespread applications in recent times. The most significant one is their antibacterial properties for which they have been used from food storage to medical supplies. The present study describes a novel green synthesis of silver nanoparticles by using Mangifera Indica and Syzygium cumini leaf extract. The green synthesized silver nanoparticles had been confirmed by UV-Vis spectrum of the reaction media. The UV-Vis spectrum of green synthesized silver from Mangifera Indica and Syzygium cumini have maximum absorbance peaks at 370 and 350 respectively. The Based on the findings, it seems very reasonable to believe that this greener way of synthesizing silver nanoparticles is not just an environmentally viable technique but it also opens up scope to improve their antibacterial...
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Posted by admin on Aug 1, 2013 in |
Traditional knowledge and ethno–botanical use of plants have been widely acknowledged all over the world. In the present scenario, emergence of multiple drug resistance to human pathogenic organisms, this has necessitated a search for new antimicrobial substances from other sources including plants. Combretum albidum, a traditional medicinal liana, used by rural peoples, villagers and tribals residing in different parts of Maharashtra, Tamil Nadu and Kerala, to treat various ailments. The Muthuvans, Chinnar tribe of Idukki district, Kerala is using stem bark of this plant as a remedy for Jaundice. The present study carried out to check the antimicrobial activity of water and methanol extracts of stem bark of C. albidum. The result showed significant antibacterial activity against Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Pseudomonas aeruginosa, Bacillus subtilis and Salmonella...
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Posted by admin on Aug 1, 2013 in |
A simple HPTLC method has been developed for the estimation of Gallic acid and Piperine in methanolic extract of Zeal herbal granules [ZHG], a Polyherbal formulation. The separation was performed on TLC aluminum plates precoated with silica gel 60 F254, good separation was achieved in the mobile phase of toluene: ethyl acetate: formic acid (11: 15: 1v/v/v) and densitometry determination of Gallic acid (0.50 Rf) and Piperine (0.70 Rf) was carried out at single wavelength scanning at 254 nm. The method validated as per ICH guideline, shows regression co-efficient value for Piperine 0.9992 and 0.9979 for Gallic acid in range of 40-90 µg/mL Recovery of Piperine and Gallic acid in final product found in range of 98-102%. Precision study (interday & intraday) showed that the relative standard deviation is less than 2%, showing method is well precise. Quantification study shows 0.23 % w/w of Piperine and 0.37 % w/w of Gallic acid in ZHG. Present study shows that developed method is simple, precise, specific, robust and accurate, and could...
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Posted by admin on Aug 1, 2013 in |
The critical nature of pharmaceutical dosage forms requires that both formulation and process variables are optimized in order to achieve desired quality outcome. In this study, process optimization is examined with a view to position the final product in such a way as to deliver the expected performance. Six formulations were designed with similar excipients and nifedipine as model drug. Each formulation went through wet granulation process, during which the granulation time, amount of granulation liquid and wet milling using different sieve sizes were modified to reflect the parameters being investigated. Results vindicated the importance of modification of process variables to the extent that significant difference was observed in the physicochemical parameters, especially in vitro dissolution and drug release rates. Data from in vitro dissolution testing was fitted into different kinetic models so as to predict the order and mechanism of drug release. It could be concluded from this research work that through logical process optimization, it is possible to identify critical process parameters that can be modified to...
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