Posted by admin on Sep 1, 2013 in |
The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carbazole (16a-20c) as a novel for the human immunodeficiency virus (HIV)-1. These compound were characterized by IR, 1H NMR and Mass...
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Posted by admin on Sep 1, 2013 in |
Fioria vitifolia L. (Linn.),(Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also used as an immune system booster. The methanolic extract of whole plant of Fioria vitifolia was taken underphytochemical investigation. The methanolic extract was partitioned with different solvent system by increasing their polarities using column chromatography, followed by thin layer chromatography for spot identification. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant .The methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema)and anti-pyretic(brewer’s yeast induced pyrexia)and anti-oxidant activities. It is used in traditional medicine for the relief of pain and inflammation in Tamil nadu, India. Preliminary studies showed the analgesic activity of methanol extract of aerial parts of the plant against Eddy’s hot plate and tail flick models and anti-inflammatory activity against carrageenan-induced model in albino rats. In this follow up studies, the major active principle was isolated by column...
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Posted by admin on Sep 1, 2013 in |
Plasmodium falciparum is the protozoan parasite responsible for the majority of life-threatening cases of human malaria, causing more than one million deaths a year. The global emergence of drug-resistant malarial parasites necessitates identification and characterization of novel drug targets. At present, α-carbonic anhydrase (CA) genes are identified in limited numbers of parasites in both protozoa and helminthes, however, the malarial genes are found in four species of Plasmodium. The CA gene of P. falciparum encodes an α- carbonic anhydrase enzyme possessing catalytic properties distinct of that of the human host CA I and II isozymes. P. falciparum native and recombinant enzymes have been prepared. Eighteen new schiff base ligand (AA01-AA18) related to previously reported potent blood schizontocidal antimalarial agent, 2-tertbutylprimaquine were synthesized and evaluated for in vivo antimalarial activities against drug-sensitive Plasmodium falciparum strain. Acute toxicity studies found that synthesized compounds were less toxic than the parent compound chloroquine, while preserving the desired antimalarial activity. Five of the analogues (AA3, AA6, AA-4, AA-9 and A-10) have exhibited curative antimalarial...
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Posted by admin on Sep 1, 2013 in |
Antibacterial activity and protein content was studied in two species of octopus belonging to the family Octopoda. The highest zone of inhibition of about 34mm and 28mm were obtained against Vibrio parahaemolyticus and theprotein content was 107.16µg/L and 136.20µg/Lin Octopus dolfusii and Octopus aegina, respectively. SDS profile revealed bands of molecular weight of about 32.83 KDa to 72.36 KDa for both the species. Conclusively, the factors analyzed prove that the sample species play an important roles in chemical defensive mechanism against pathogens causing diseases in human and fishes. This study paves a way for further pharmaceutical research against pathogenic bacterial strains producing valuable...
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Posted by admin on Sep 1, 2013 in |
The present study involves in the preparation and evaluation of floating tablets of Salbutamol sulphate by direct compression method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose, Dextrin and Carbopol. Sodium bicarbonate, Tartaric acid and citric acid were incorporated as gas generating agent. The study aims to achieve different formulations using different polymers in order to find out the most suitable and successful type of polymer. The prepared tablets were evaluated in terms of thickness, average weight, hardness, friability, drug content uniformity, swelling index, in- vitro buoyancy study and in-vitro dissolution study. The formulated tablet Hardness was found to being the range of 2.6 to 3.8 kg/cm2, the % friability was in the range of 0.30 to 0.50. The Swelling Index and floating time of different formulations range from 1.78 to 16.15 and 8.15 to 12 hrs respectively. In-vitro release studies were carried out using USP XXII dissolution test apparatus. The tablet containing Salbutamol sulphate was released from batch F1-F10 found...
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