Posted by admin on Nov 1, 2013 in |
A series of different 6-Methyl – 4- aryl -5 – (5-aryl -1,3,4-oxadiazole-2-yl ) -1,2,3,4-tetrahydro pyrimidin-2- (1H) – one / thione ( IIIa-g) have been synthesised fromEthyl – 6- methyl- 2- oxo / thioxo – 4-substituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (Ia-g) followed by reaction with hydrazine hydrate in ethanol gave 6 – methyl-2-oxo / thioxo – 4 -substituted phenyl – 1,2,3,4-tetrahydro pyrimidine-5-carbo hydrazide (IIa-g) by means of Microwave irradiation for 2-4 mins and giving excellent yield in short reaction time, are notable advantages of this method. The structure elucidations of all the synthesised compounds have been accomplished by elemental analysis, IR, NMR and Mass spectroscopic...
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Posted by admin on Oct 1, 2013 in |
Most of the traditional systems of medicines are effective but the need is just to validate them to assess the quality, quantity and purity of the drugs. To support the same a polyherbal Ayurvedic powdered formulation Shatavaryadi churna used as immunomodulator, galactagogue, aphrodisiac and rejuvenator was taken for pharmacognostical, physicochemical and elemental investigation. Shatavaryadi churna is the composition of five ingredients, i.e. powder of Asparagus racemosus Willd. tubers-1part, Tribulus terrestris Linn. fruits- 1 part, Mucuna pruriens (L.) DC seeds- 1 part, Withania somnifera Dunal. roots- 1 part and Chlorophytum tuberosum Baker bulbs- 1 part. Ingredients of the formulation, In-house formulation and Marketed formulation have been pharmacognostically, physicochemically and elementally characterized by microscopy, physical constant values and Energy Dispersive Spectroscopy. Selected parameters for the investigation were anatomical study; powder microscopy; Extractive values i.e. alcohol soluble, water soluble, chloroform soluble, ethyl acetate soluble and petroleum ether soluble; Ash values i.e. total ash, water insoluble ash, acid insoluble ash; moisture content value, foreign matter and elemental content. The set parameters were found...
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Posted by admin on Oct 1, 2013 in |
On the basis of various literature survey, imidazole derivatives show various activity such as antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic imidazole nucleus. Having structural similarity with histidine imidazole compound can bind with protein molecules with ease compared to the some other heterocyclic moieties. Thus imidazole offers better pharmacodynamic characteristics. Furthermore, some imidazole drugs, at high concentrations, could exert direct inhibitory effects on membranes, without interference with sterols and sterol esters. Various recent new drugs developments in imidazole derivatives show better effect and less toxicity. Prompted by the broad spectrum activities of 2, 4, 5- triphenylimidazole derivatives, it was decided to synthesize various 2, 4, 5-triphenyl-1-substituted imidazoles and to evaluate them for their pharmacological...
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Posted by admin on Oct 1, 2013 in |
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage purity was found to be 99.94% and an excellent mean recovery (98.65%-100.7%). The method was validated statistically and it can be employed for the routine analysis of Rizatriptan benzoate in marketed...
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Posted by admin on Oct 1, 2013 in |
The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, HDL,VLDL and organs to body weight ratio were studied. The histo-pathological study was carried out by High Fructoseinduced diabetic and anti-diabetic rats pancreas. Statistical analysis of the results shown that in High Fructoseinduced diabetic rats chloroform and alcohol extracts of Xylia dolabriformis leaves at 40, 80, 160 and 200 mg/kg doses. Xylia dolabriformis leaves extract improved renal creatinine clearance, decreased the LDL, VLDL, increased the HDL and reduce renal total protein loss demonstrating nephroprotective and cardioprotective properties. The organ to body weight ratio studies carried out on last day, shown pancreas and liver specific effects of Xylia dolabriformis leaves. These results were also supported by histo-pathological studies. We conclude from the present study that Xylia dolabriformis alcoholic...
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