Posted by admin on Sep 1, 2013 in |
Tuberculosis is the major public health problem in throughout the world caused by Mycobacterium tuberculosis. Result indicates that micronutrient deficiency is common in patients with tuberculosis. As per in this study patients with newly diagnosed tuberculosis patients were divided into four groups. One group (n=41) received a placebo, second group (n=47) received 5000 IU vitamin A as retinyl acetate, third group (n=49) received 15 mg zinc as zinc sulphate and fourth group (n=41) received both 5000 IU vitamin A as retinyl acetate & 15 mg zinc as zinc sulphate. All groups received the same antituberculosis treatment (ATT). Results there were no significant differences in biochemical status amongst groups at baseline. After 2 months, the number of patients with sputum smears negative for tubercle bacilli was almost equal in all the groups (Group A-90.6%, Group B-90.3%, Group C-91.4% and Group D=93.1%). After 2 and 6 months of ATT, the increase in hemoglobin, serum albumin, vitamin A and zinc concentrations were significantly higher in the micronutrient group than in the placebo...
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Posted by admin on Sep 1, 2013 in |
A new, simple and sensitive spectroscopic method has been developed for the estimation of Atorvastatin calcium hydrate residue by using swabbing technique. In the proposed method the absorbance was measured 245.0nm corresponding to the absorbance maxima of Atorvastatin calcium in the ratio methanol and water as 90:10 as a solvent. Shimadzu-2450 UV-Visible spectrophotometer with UV Prove 2.31 software, capable of multi-component analysis, was used for quantization. Linearity range was observed in the concentration range of 1-10μg/ml for Atorvastatin. The % recovery of Atorvastatin was found out to be 100.2%. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and...
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Posted by admin on Sep 1, 2013 in |
A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesized in good yield. The structures of the compounds obtained have been established on the basis of Spectral (IR, 1H NMR, 13C NMR and Mass) data. The present study also involves in vivo anti- inflammatory activity and in vitro antibacterial activity against few strains (gram positive and gram negative) of bacteria of synthesized compounds. Derivatives 6a, 6e and 6g exhibit promising anti-inflammatory and antibacterial activity with reference to standard drug Indomethacin and Ampicillin...
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Posted by admin on Sep 1, 2013 in |
The main objective of the present study is to evaluate the effect of pH of enteric polymer [methacrylic acid ethyl acrylate copolymer dispersion (Eudragit L30 D-55)], on dissolution profile of Duloxetine HCl delayed release formulation with the Tlag of 2hrs. The said formulation was formulated using fluidized bed process in three separate layers, the drug layer, the barrier layer and the enteric layer, were coated on sugar spheres. The enteric coated pellets were top coated using a film coating material, filled in hard gelatin capsules. Eudragit L30-D55 is used as such and neutralized to different pH (pH 4.00, pH 4.25, pH 4.50, pH 4.75, pH 5.00 and pH 5.25), coated on barrier coated pellets. The formulation coated by using enteric polymer neutralized to pH 4.75 shows the maximum extent of dissolution (91.8%) in 0.1N HCl for 2 hrs followed by pH 5.5 phosphate buffer at...
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Posted by admin on Sep 1, 2013 in |
The present study was an attempt to investigate the feasibility of the matrix based sustained release unit dosage formulation of cefixime trihydrate. Matrix tablets were prepared by using xanthan gum along with the other polymer combinations (Guar gum, sodium alginate and hydroxypropylmethyl cellulose). Effect of different formulation variables like polymer concentration, ratio of polymer combination and compression force was evaluated. The Fourier transform infrared spectroscopy,differential scanning calorimeter and X ray diffraction analysis were also carried out to evaluate physico-chemical compatibility between drug and excipients. In vitro release results suggested a 24 h controlled drug release from the prepared tablet of cefixime trihydrate. Swelling and erosion studies were performed to verify the release mechanisms involved in the formulation. In vitro antimicrobial study was also performed to check the synergistic efficacy of CFT with excipients. The formulations were found to be stable up to 3 months of stability testing at 40ºC/75%...
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