Posted by admin on Jul 1, 2013 in |
Catharanthus roseus is a medicinal herb found in many tropical and subtropical regions around the world. This plant produces a diverse array of secondary metabolites that are pharmaceutically important like vinblastine and vincristine used as chemotherapeutic agents in the treatment of several types of cancers. Low yield of these vinca alkaloids from the plant in vivo and the challenges to meet their high demand worldwide led researchers to develop various in vitro techniques like hairy root culture, callus cultures, shoot cultures, metabolic engineering and regulation studies to increase their production. The present review gives an account of the various phytochemicals derived from the plant and the pharmacological aspects of secondary metabolites studied. Present review also highlights the biotechnological prospects of an efficient and alternative means of production of valuable metabolites from Catharanthus roseus and also from rich microflora residing inside the plant tissues. It gives an emphasis on the need of exploration of diverse niches of...
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Posted by admin on Jul 1, 2013 in |
The focus of this exploratory study was to investigate pharmacy academics’ perception of their role in the Libyan health. A cross sectional survey design was used in this study. Using a questionnaire developed following an extensive literature review, a survey cross was undertaken in Libya from June to September 2010. The respondents’ were pharmacy academics who had graduated from pharmacy faculties and were teaching at Libyan pharmacy faculties naming universities (Alfateh Tripoli and Alarab Medical Benghazi). The majority of respondents’ reported that they did not teach courses related to social pharmacyin their institutions.There was substantial willingness among academics to incorporate social pharmacy subjects to pharmacy curriculum in Libya. The results obtained from the present study revealed that social pharmacy subjects are not fully thought and given priority in the Libyan pharmacy...
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Posted by admin on Jul 1, 2013 in |
Polychlorinated dibenzo-p-dioxins(PCDDs) and Polychlorinated dibenzofurans(PCDFs) represent a large group of industrial and byproduct compound is resistance to chemical and biological degradation and highly toxic.A series of 18 PCDD and PCDF compounds is subjected to QSTR studies by using differnt molecular descripters. The dependent variable used in this study represents log(EC50) values (EC50-median effective concentration during a bioassay).The regression analysis of the data has shown that the toxicity of the compound can be modeled excellently in multi-parametric model.Its resulting model exhibited good R2value up to 0.8938. The present work contribute in the identification of those compounds which are very toxic and polluting our...
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Posted by admin on Jul 1, 2013 in |
The objective of the study is to design gastro retentive drug delivery systems for Amoxycillin trihydrate. It was prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. The preparation was carried out by using guar gum as a carrier in the form of a three-layer matrix tablet. Amoxycillin trihydrate was chosen as a model drug because of its site-specificity. Matrix tablets containing either 30 % (M) of guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of Amoxycillin were prepared by compressing on both sides of guar gum matrix tablet granules of Amoxycillin M with either 50 (TLM) of guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for weight variation, hardness, friability, buoyancy and in-vitro dissolution studies. Optimized formulation of amoxicillin was found to have increased gastric residence prolonging the...
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Posted by admin on Jul 1, 2013 in |
The present work describes a validated reverse phase high performance thin layer liquid chromatographic method for simultaneous estimation of Diclofenac sodium and Famotidine in bulk and in pharmaceutical dosage form. Chromatographic separation of the drugs were performed on aluminum plates precoated with 200-μm layers of silica gel 60 RP-18 F254S as the stationary phase and the solvent system consisted of methanol: water: triethylamine (7.5:3.5:0.5) (v/v/v). Densitometric evaluation of the separated zones was performed at 291 nm. The two drugs were satisfactorily resolved with Rf values 0.54 ± 0.02 and 0.69 ± 0.02 for Diclofenac Sodium and Famotidine, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity over the range of 1500 ng/band to 9000 ng/ band for Diclofenac Sodium and over the range of 500 ng/ band to 3000 ng/ band for Famotidine...
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