Posted by admin on Jul 1, 2013 in |
Nanotechnology is widely used for delivery of various drugs to the body for increasing the bioavailability, reducing toxicity and controlled release.Nanospheres are the solid particles which are spherical in shape, having the particle size range between 1-1000 nm and having better bioavailability. In nanospheres, the drug is physically and uniformly dispersed in the matrix system of the polymer. Nanospheres of Propranolol Hydrochloride were prepared by using solvent evaporation technique with different concentration of Eudragit RS100 and Eudragit RL100 polymers. The different formulation factors like drug: polymer ratio, concentration of solvent, stirring speed, stirring time on particle size, drug encapsulation, drug efficiency, surface morphology, and process yield and drug release behavior was studied. The in-vitro performance of nanospheres were evaluated by recovery efficiency, particle size analysis, surface topography (using scanning electron microscopy), drug-polymer compatibility (using differential scanning calorimetry) and drug release studies. The single emulsion solvent evaporation method used for nanospheres preparation was suitable in the particle size range between 265.67±3.98 nm, the encapsulation efficiency was 74.67±2.56% (w/w) and the...
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Posted by admin on Jul 1, 2013 in |
The new chalcones of 2-acetyl-5-methylfuran derivatives are synthesized by reaction with various aromatic and hetero aromatic aldehydes using the method of aldol condensation. Characterization of these synthesized compounds performed with IR, 1H NMR, physical characteristics like molecular mass, melting point and elemental analysis. The data related to structural characterization were given individually with antimicrobial activities.Characterization of these synthesized compounds performed with IR, 1H NMR, physical characteristics like molecular mass, melting point and elemental analysis. The data related to structural characterization were given individually with antimicrobial activities. The literature suggests that chalcones are also useful intermediates for the synthesis of several chemical and pharmacological classes of therapeutic agents having heterocyclic structures in them. Also a number of chalcones with novel substituents synthesized, characterized and biologically evaluated for anti-microbial activity in our laboratory and significant outcome was observed. Thus various novel substituents for chalcone synthesis and QSAR studies will be a promising effort for development of better anti microbials with several significant biological...
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Posted by admin on Jul 1, 2013 in |
A new simple, rapid, precise, accurate and specific RP-HPLC method was developed to carry out the quantification of Andrographolide in the formulation vis a vis its standardization to ensure the batch to batch consistency in mycotoxin inhibition activity of the polyherbal formulation Toxiroak premix. An optimal condition of separation and detection were achieved on a Phenomenex luna C18 column (250 mm x 4.6 mm, 5 μm) using isocratic mixture of Acetonitrile and 0.1 % ortho-phosphoric acid in a ratio of 40:60,v/v as a mobile phase, 1.0 ml/min as flow rate 226 nm as the wavelength for detection and quantification. To verify the the efficiency of chromatographic run, the system suitability was studied by taking into account number of theoretical plates and symmetry / tailing factor which were found to be consistent during repeated injections . The method was validated for linearity, selectivity, accuracy, precision, repeatability and recovery in accordance with the statistical method of validation and is useful for establishing the batch to batch...
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Posted by admin on Jul 1, 2013 in |
Bacillus circulans strain isolated from dump yards of vegetable wastes was tested for its abilities to hydrolyze the structural polysaccharides. The effect of different production parameters such as pH, temperature, carbon source, nitrogen source (Organic and inorganic), incubation time, inoculum sizes and surfactants on pectinase production by the isolated bacterial strain was studied. The enzyme production was assayed in submerged fermentation (SmF) condition. The maximum pectinase production was observed with Galactose (256 U/ml), Yeast extract (130 U/ml), Ammonium sulphate (72 U/ml), pH 7.0 (236 U/ml), Temperature 40°C (126 U/ml), Tween-80 (144 U/ml), Incubation time 48 hours (166 U/ml) and Inoculum size level 5% (136 U/ml) in the production...
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Posted by admin on Jul 1, 2013 in |
The present study was designed to compare the antioxidant, antimicrobial and thrombolytic effects of the Lannea coromandelica bark and leave extracts. After the initial phytochemical screening, the ethanolic fractions of the L. coromandelica bark and leaves were partitioned by solvents of different polarity. Methods used to evaluate the antioxidant potential of the extracts were total phenolic content, total flavonoid content, free radical scavenging capacity, total antioxidant capacity and reducing power assay. Total phenol and total flavonoid contents were found to be the highest for bark and leaves in the ethyl acetate fraction and lowest in the n-Hexane fraction. In DPPH free radical scavenging test, the lowest IC50 value was found in the ethyl acetate fraction of the bark and leaf, resulting IC50 value of 3.8±0.14 μg/ml and 6±0.32 μg/ml respectively. In the same vein, ethyl acetate fraction of both leaf and bark showed the highest antioxidant capacity and reducing power. Reducing power of both bark and leaves were found to be concentration dependent and most prominent was observed with...
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