Posted by admin on Aug 1, 2013 in |
Various medicinal properties have been attributed to natural herbs. The use of traditional medicine is widespread in India. These herbal remedies are an important source for the discovery of new antimicrobials against the resistant strains of bacteria. Asavas and Arishtas are specially prepared ayurvedic medicines. They are alcoholic solutions containing all the active ingredients of the drugs of which they are compounded. Asavas are prepared by using herbal juices or herbs soaked in water while Arishtas are prepared by decoction. Different parts of medicinal plants are used traditionally for the preparation of specific asava or arishta that is effective against specific disorder. About 25 different medicinal plants commonly used were selected. Dried powders of these plants were extracted in water. The antibacterial activity of the extracts were then tested by agar well diffusion method against standard cultures of Escherichia coli, Klebsiella aerogenes, Proteus vulgaris, Salmonella typhimurium, Staphylococcus aureus and Bacillus thuringenesis. The individual extracts of Emblica officinalis, Terminalia chebula, Terminalia belerica andWoodfordia fructicosa, Jaggery were active against the test...
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Posted by admin on Aug 1, 2013 in |
The principal derivative of chitin is Chitosan, produced by alkaline deacetylation of chitin, is a non-toxic, biodegradable and biocompatible, cationic polymer. Chitosan has been widely used in the formulation of particulate drug delivery systems to achieve controlled drug delivery. The main objective of the study was to develop enteric coated Chitosan capsule containing budesonide for targeting the ileum and ascending colon sites which were mainly affected in Crohn’s disease. This work describes a new colonic drug delivery system utilizing capsule shells prepared from Chitosan. Coating of drug filled Chitosan capsule with pH dependent enteric polymer like Eudragit S100 / L100 (1:1) provides it a special feature of releasing drug at colonic pH. The in-vivo study involves the Gamma scintigraphic evaluation of enteric coated Chitosan capsule. The enteric coated Chitosan capsule proved to be efficient to deliver the drug at ileum and ascending colon in Crohn’s...
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Posted by admin on Aug 1, 2013 in |
The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drug like Ezetimibe. It is a poorly soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs, in which the “liquisolid compacts” is a promising technique. Different formulations were prepared by using polyethylene glycol-400 as a non-volatile liquid vehicle, with drug and vehicle ratios of 1:5 and 1:7.5, microcrystalline cellulose (Avicel PH 102), starch were used as carrier materials and nm-sized silica gel (Aerosil-200) was used as coating materials. The empirical method introduced by Spireas and Bolton was applied to calculate the amounts of coating and carrier materials required to prepare Ezetimibe liquisolid tablets. Based upon this method, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 20:1 to 5:1. They were characterized for different physical...
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Posted by admin on Jul 1, 2013 in |
This study is an effort to assess Analgesic and anti-inflammatory property of widely used Ayurvedic preparation Amlapittantak Ras. In current study, the effects of APR were evaluated through validated animal models of pain including Hot plate, acetic acid-induced writhing, formalin-induced paw licking and Xylene induced ear edema test. In hot plate method, APR treated mice at doses 200 and 400mg/Kg causes a significant (p<0.001) inhibition of writhing responses. When compared to the control it was shown percent inhibition of 57.9% and 61.7% at 4th hour with a dose dependent manner. In Writhing test the result was significant (P<0.1 and P<0.001) with writhing inhibition 36% and 61.33% at doses 200 and 400 mg/kg respectively. In paw licking testthe APR was highly significant analgesic effect (p=0.00195**) but the anti-inflammation result was not statistically significant. At dose 100mg/kg, APR treated male mice exerted a decrease in inflammation in the xylene induced ear edema test when compared to the corresponding control group, which was not statistically significant. From this result it can be...
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Posted by admin on Jul 1, 2013 in |
The two species of Withania i.e. Withania obtusifolia and Withania somnifera were usually misinterpreted because of their co-existence in mixed populations. The present investigation involves analyzed of interspecific relationship between these two species. A careful morphological, anatomic and phytochemical, identification of the two species has led to the findings that there was a slight variation between these two species. SDS-PAGE has been effectively used for the comparative study of proteins profiles in leaf and seeds of W. somnifera and W. obtusifolia. The RAPD analysis of W. somnifera and W. obtusifolia encouraged us to think positively that there are most considerable genetic variations between these two species. This result was the most important evidence for differences between the two Withania...
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