Posted by admin on May 1, 2013 in |
Aim: To evaluate anti-inflammatory effects of losartan in experimentally induced rheumatoid arthritis (RA). Materials and Methods: Adjuvant induced arthritis model is used in this study. Albino-Wistar rats of either sex were used. Arthritis was induced by single intra-plantar injection of Freund’s complete adjuvant (FCA) suspended in oil in right hind paw. Rats were divided in to three groups (n=8) namely disease control, standard and test group. Drug treatment was carried out for 21 days. Effect of test drug on acute inflammatory phase was evaluated on day 5 by assessing right hind paw edema. After 21 days animals were sacrificed and evaluated for left hind paw edema, weight changes, histo-pathological synovitis grading in left hind limbs and secondary lesion score. Results: Results showed that losartan significantly reduced right hind paw edema on day 5 (p<0.05) and showed significant weight gain (p<0.05). Losartan though reduced the histo-pathological synovitis grade and secondary lesion score was not statistically significant (p>0.05). Conclusion: Our study suggests that losartan could be a potential candidate for treatment...
Read More
Posted by admin on May 1, 2013 in |
Oral controlled release pellet formulations of glipizide were prepared using extrusion spheronization technique. Pellets provide specific advantages in controlling the drug release and increasing the absorption of the active ingredient. The major drawback for these systems is dose dumping which is very prominent in presence of alcohol. In the present study, attempt was made to prepare alcohol resistant pellet formulations of glipizide. Glipizide is an oral anti-diabeticdrug belonging to the sulfonylurea group, used for the treatment of non-insulin dependent diabetes mellitus (NIDDM). Various polymers like Eudragit RSPO, RLPO and cellulose acetate butyrate were used for preparing the pellets. The prepared pellets were studied for different flow properties and drug release studies. The in vitro drug release studies were carried out in phosphate buffer as well as in phosphate buffer containing 5% alcohol. Drug release from the pellets was by non fickian diffusion mechanism and was comparable with that of marketed preparations. The pellets also had shown resistance to alcohol dose...
Read More
Posted by admin on May 1, 2013 in |
The main objective of the present investigation is to evaluate the analgesic activity of ethanolic extract of Tamarindus indicaL. on mice. Analgesic activity of the ethanolic extract of the Tamarindus indica leaves at a dose of 200mg/kg & 400mg/kg was evaluated against the standard drug Diclofenac-Na at a dose of 25mg/kg. Adult Swiss albino mice of either sex of divided in to 4 groups comprising six numbers in each group was undertaken for study and evaluated by tail immersion method. The three doses of T. indicaleaves ethanolic extract was found to produce significant (p < 0.05) analgesic activity. In tail immersion method the crude extract produced elongation of time 30 minutes after oral dose of 200 and 400 mg/kg body weight respectively. 400 mg dose of Ethanolic extract of Tamarindus indica show analgesic activity comparable to 25mg Standard drug (Diclofenac sodium). 400mg Ethanolic extract of Tamarindus indica shows better result in comparable to standard drug. Ethanolic extract of Tamarindus indicaleaves have potential analgesic activity against stimuli in the tested...
Read More
Posted by admin on May 1, 2013 in |
In the present study, novel derivatives of substituted cis-stilbene were prepared from benzyl (chloro) triphenyl phosphorane, substituted phenyl acetic acid and In vivo anti-inflammatory activity was evaluated by carrageenan- induced rat paw edema assay model. The newly synthesized compounds were characterized by IR, 1H NMR and Mass analyses. The results revealed that all the test compounds protected the rats from carrageenan induced inflammation and the test compounds showed a significant anti-inflammatory activity against the control group. Among the compounds tested 1i, 1l, 1o, 2c, 2d, 2h, 3b and 3d showed better anti-inflammatory activity and 2f, 3c showed moderate...
Read More
Posted by admin on May 1, 2013 in |
Objective: To evaluate the efficacy of aqueous and methanolic extracts of plant Desmodium triflorum for potential antibacterial activity. Materials and Methods: Phytochemical analysis of Desmodium triflorum belonging to family Fabeacea was examined using aqueous and methanolic extracts. Methanolic and aqueous extracts of whole plant were investigated individually for antibacterial activity by agar disc diffusion method as well as by agar well diffusion method. Both the extracts were tested against selected species of Staphylococcus aureus (G+ve), Micrococcus luteus (G+ve), Bacillus pumilus (G+ve), Pseudomonas aeruginosa (G-ve), Pseudomonas fluorescens (G-ve), Escheria coli (G-ve) to find the inhibitory activities of microbes at the dose level of 50 and 100 µg/ml. Result: The phytochemical analysis of aqueous and methanolic extracts confirmed the presence of alkaloids, steroids, tannins, saponins and flavonoids. Methanolic extract of Desmodium triflorum showed considerably high antibacterial activities against (G+ve) bacteria than aqueous extract. Conclusion: Although the active components were not isolated but antibacterial active plant principles such as flavonoids, alkaloids and tannins were observed in the extract. Methanolic extract of Desmodium...
Read More
