Posted by admin on Apr 1, 2013 in |
With the blend of Methocel K15, a synthetic polymer and xanthan gum, a natural polymer (3:1) was used in the formulation of matrix tablets to find out the effect of natural polymer in the sustained release dosage form. Direct compression process was applied for the preparation of Ketotifen fumarate tablets. The dissolution profiles were carried out by USP apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl and distilled water. For interpreting the results a one way analysis of variance (ANOVA) was exploited. Statistically significant differences were found among the drug release profile from different matrices. At a higher polymeric content (60% of the total tablet weight), drug release from the combination of Methocel K15M and xanthan gum (3:1) was slower. On the contrary, at a lower polymeric level (30% of the total tablet weight); the rate of drug release was prominent. The best-fit release kinetics was accomplished with the Higuchi model followed by the zero-order plot, Korsmeyer and Hixson Crowell equations. One formulation showed drug...
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Posted by admin on Apr 1, 2013 in |
The concerned study reveals the first time experimental investigation of Hypoglycemic and antihyperglycemic effect of seed extract of Acacia tortilis plant was in normoglycaemic and Alloxan-induced (135 mg/Kg body weight intraperitoneally) diabetic rats. The seed extract at the dose of 100 and 200 mg/kg body weight was administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) and blood glucose estimation was done in all groups. The extract significantly lowered the blood glucose levels to an extent comparable to that produced by standard Oral hypoglycemic drug (Gliclazide 22 mg/Kg body weight) in both normal and diabetic rats. The results suggest that seed extract of Acacia tortilis possess significant antidiabetic activity. The extract seems promising for the development of a phytomedicine for diabetes mellitus in future...
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Posted by admin on Apr 1, 2013 in |
In this study, five different products of each metronidazole tablets and benzoate salt oral suspensions were purchased from the different retail outlets in the local market of Addis Ababa and analyzed using official methods (Pharmacopoeial methods of USP/BP/IP) by employing HPLC for the tablet dosage forms and non-aqueous titration with potentiometric end point for the suspensions. The assay results showed that all brand and generic products of metronidazole tablets and metronidazole benzoate oral suspensions met the USP and the IP specifications, respectively. Furthermore, all the tablets analyzed have passed the hardness, friability and weight variation tests. All tablets except metrogyl passed the disintegration time test and dissolution rate test specifications of BP/USP. In addition, different brands and a generic product of metronidazole benzoate oral suspensions were evaluated by determining their physical stability with respect to the two useful parameters, sedimentation volume and Viscosity. Amrizole has relatively moderate viscosity (728.0 ± 0.12 cP), which may cause good pourability of the suspension with a sedimentation value of 1 (acceptable and stable...
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Posted by admin on Apr 1, 2013 in |
The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant free radical scavenging activity with IC50 value of 119.0µg/ml for S. japonica stem. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The LC50 value of sample CTJS (Carbon Tetrachloride fraction of S. japonica Stem), was 3.0µg/ml is highly most significant. Antibacterial activity was tested by disk diffusion method. The Carbon Tetrachloride soluble fraction showed good antibacterial activity against different species of bacteria at different doses. The Ethyl Acetate soluble fraction shows good activity only against E. coli at different...
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Posted by admin on Apr 1, 2013 in |
Adenia lobata Engl (Passifloraceae) is a woody climber which grows in most African countries mainly the coastal belt. It is an important medicinal plant used to treat haemorrhoids, malaria, fever, diabetes and gonorrhea. In our attempt to find out the constituents of this medicinal plant, the dried stem powder of A. lobata was successively extracted by Soxhlet with petroleum ether and 70% ethanol to obtain the crude petroleum ether (PEAL: yield =1.1w/w %) and ethanol (EEAL: yield = 5.4 w/w %) extracts. The antihyperglycaemic activity of PEAL and EEAL were determined in streptozotocin-induced diabetic rats (70 mg/kg body weight). The ethanol extract was most active and was subjected to chromatographic separation to isolate its chemical constituents. The isolated compounds were identified using NMR spectroscopic namely 1H, 13C NMR, COSY, HSQC and HMBC Spectroscopy with reference to literature. Two compounds isolated from the extract were found to be, palmitic acid and g-hydroxy-d-valerolactone. To the best of our knowledge, this is the first time these compounds are reported from this medicinal...
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