Posted by admin on Jul 1, 2013 in |
The Present study focuses on the challenges facing the development of oral insulin the fact we have no formulation in market, being an attractive and advantageous over the regular injections. Physiological and biological factors of the insulin has great influence for the development of an oral formulation with many difficulties regarding the stability over gastric pH and proteolytic enzymes, selection of the proper formulation and its components depends on these conditions. The development with insulin therapy are needed with better patience compliance, low toxicity, higher glycemic control, thereby Diabetes related complications occurrence can be...
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Posted by admin on Jun 1, 2013 in |
The new Ru (II) complex [Ru(4-Et-py)4(dppz)]2+ (dppz = dipyrido phenazine) have been synthesized and characterized by different analytical techniques like elemental analysis, LC-MS, 1H NMR , 13C NMR. The interaction of this complex with calf thymus DNA has been explored by U.V. absorption spectroscopy, Fluorescence measurements, and viscosity measurements. Their photocleavage behavior towards pBR 322 and anti-bacterial properties of this complex was also investigated. The experimental results show that the complex binds with DNA by intercalation...
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Posted by admin on Jun 1, 2013 in |
Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing 0.05% w/w Clobetasol-17-propionate (CP) as active ingredient are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipophilic stratum cornium and much more viable epidermis. Penetration enhancers are thought to intact with one component of skin causing the stratum cornium to swell or leach out some of the structural component their by increasing the drug penetration to the barrier membrane. The current study was carried out to study the effect of various penetration enhancers such as oleic acid (OA), isopropyl myristate (IPM), polysorbate 80 (PS) and thymol (TM) on topical delivery of Clobetasol-17-propionate (CP) and was evaluated in-vitro using cellophane membrane as well as rat skin mounted in Franz diffusion cell. CP was analyzed spectrophotometrically at 240 nm. The efficiency of penetration enhancers to improvise topical delivery of CP was observed in the order...
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Posted by admin on Jun 1, 2013 in |
A simple, specific, precise, and efficient method for the Simultaneous estimation of Metformin HCl and Voglibose tablet by a Reverse Phase-High Performance Liquid Chromatography method is developed and validated. Selected mobile phase were in a combination of acetonitrile: buffer pH- 6.5 in the ratio of 62:38. Optimized column is a stainless steel column packed with base octa decylsilyl silica gel of 250X4.6mm and at 254 nm wavelength for metformin and Voglibose detection by Spectrofluorimeter and excitation wavelength at 350nm and emission wavelength at 430nm. In our study, the validation of analytical method for determination of Metformin and voglibose tablet formulation was performed in accordance the parameters including-system suitability, specificity, linearity of response, accuracy, precision (reproducibility & repeatability), robustness (change of wave length±2 nm). The method is validated according to ICH...
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Posted by admin on Jun 1, 2013 in |
The aim of present study was to develop a new colon targeting formulation, which can minimize the escape of Mesalazine completely in upper gastro-intestinal tract and ensure availability of maximum amount of drug to achieve the desired site i.e. distal colon. The use of press coated tablets with Hydroxypropylmethylcellulose acetate succinate (HPMCAS) and sodium alginate in outer shell was investigated. Two coats (upper and lower) were compressed onto the core tablets of Mesalazine using varying quantities of coating composition i.e. 100mg and 150mg each for lower and upper coat. The Mesalazine tablets coated by compressing 100 mg of HPMCAS each as upper and lower coat did not maintain integrity of the coats and released almost 100% of drug within 3 hrs. The tablets coated by compressing 150 mg of HPMCAS on the core tablets maintained good integrity during the dissolution test and prevented escape of Mesalazine totally in acid stage and buffer sage 1. However, the release of Mesalazine in subsequent buffer stage 2 was also affected. Mesalazine tablets...
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