Posted by admin on Apr 1, 2013 in |
Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties. The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug development and it should be considered as early as possible in the drug discovery...
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Posted by admin on Apr 1, 2013 in |
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100% methanol, 80% methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There was no significant (P<0.05) difference in the moisture, fat and ash content. All the three samples were found to be good sources of major minerals viz. Iron, Calcium phosphorus and also of trace elements like manganese, zinc, copper, potassium.S36 found to be rich in phytochemicals and antioxidants. The polyphenol content was in the order...
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Posted by admin on Apr 1, 2013 in |
The aim of the present investigation is to formulate and evaluate Tizanidine hydrochloride sustained release pellets. Tizanidine hydrochloride is an immadazole α2-adrenergic agonist used in the management of increase in muscle tone associated with spasticity. It has short biological half-life of 2- 2.5 hrs and is rapidly eliminated from the body. Sustained release dosage form of Tizanidine hydrochloride was developed for reduction in total amount of dose administration, to improve patient compliance, and increase efficiency in the treatment. The pellets were prepared by pan coating and fluidized bed coating technique (Wurster type) using hydroxy propyl methyl cellulose E5 (HPMC E5), Ethyl cellulose N-50, Eudragit L-100 as polymers and Isopropyl alcohol, Methylene dichloride as solvents. The pellets are filled in capsules and evaluated for weight variation, content uniformity, moisture content, lock length, disintegration and in-vitro dissolution tests and the results were found to be within the limits. A comparative study of dissolution profile of different batches with marketed product was performed. The optimized batch showed good similarity with the marketed...
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Posted by admin on Apr 1, 2013 in |
A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obeyed in the concentration range of 50-250 μg/ml. Statistical analysis proves that the proposed method is reproducible and selective for the routine analysis of pharmaceutical formulations of...
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Posted by admin on Apr 1, 2013 in |
Scindapsus officinalis (Roxb.) Schott fruits are widely used in many parts of India for the treatment of various diseases. It is one of the plants used in Indian system of medicine which belongs to family Aracea. It has the significant antioxidant property due to presence of flavonoids and phenolic compound and has ability of cytoprotection due to antioxidant property. Hydroalcoholic extract (50%Ethanol) of Scindapsus officinalis fruit was prepared and evaluated for its hepatoprotective Potential against paracetamol-induced hepatotoxicity in rats. Alteration in the levels of SGPT, SGOT, ALP, bilirubin, total protein and tissue GSH, GSSG and MDA were tested in both treated and untreated groups. SGPT, SGOT, ALP and bilirubin was enhanced significantly (p<0.05) in Paracetamol (2mg/kg B.wt.) treated group and total serum protein, tissue MDA rise and tissue level of GSH was significantly (p<0.05) reduced in Paracetamol (2mg/kg B. wt.) treated group. Pretreatment with Hydroalcoholic extract (50% Ethanol) of Scindapsus officinalis fruit (200mg/kg B. wt. and 400 mg/kg B. wt.) has brought back the altered levels of biochemical markers...
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