Posted by admin on Apr 1, 2013 in |
Present study was done to evaluate the memory enhancing effect of Aegle marmelos and its comparison with the present standard treatment Piracetam in Wistar rats. The learning and memory was assessed using the elevated plus maze. The findings of the present study indicate that, Aegle marmelos extract treated animals at a dose of 100 mg/kg p.o. as well as 200 mg/kg p.o. showed significant decrease in transfer latency from 6th day to 7th day (p<0.05), but the percentage reduction was more with higher dose. When compared to the control group, this reduction was statistically significant (p<0.05). These findings demonstrate the facilitatory effect of Aegle marmelos on learning and memory (nootropic activity). This may be attributed to the involvement of neurotransmitters like acetylcholine, serotonin, noradrenaline and dopamine, which play a vital role in the cognitive...
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Posted by admin on Apr 1, 2013 in |
The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp lethality bioassay. A reputed cytotoxic agent, vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that n-hexane, ethyl acetate, chloroform soluble fractions of Azadirachta indica possess cytotoxic principles (LC50 1.429 mg/mL, 2.368mg/mL and 1.479 mg/mL respectively) comparison with positive control vincristine sulphate (LC50 0.563...
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Posted by admin on Apr 1, 2013 in |
Purpose: The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. Methods: Histopathological alterations in the developing ovaries were examined in neonates from birth to 21st day of weaning on specific days viz. 1, 7, 14 and 21st day of postnatal development. Lead acetate was administered via oral gavaging at 266 mg/kg/bodyweight and 1066 mg/kg/bodyweight to pregnant Swiss mice from 10th day of gestation to 21st day of lactation. Results: Studies conducted on females revealed mostly miscarriages, premature delivery and infant mortality. Lead suppresses the development of various follicles during fetal and neonatal life. Conclusion: It appears that lead interferes during specific events of ovarian developmental stages, which may create higher sensitivity for dysfunction in reproductive system during adulthood. The present investigation evaluates the relative...
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Posted by admin on Apr 1, 2013 in |
Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipients (surfactants and carriers) was heated first and then hardened by cooling to room temperatures. They were then pulverized, sieved, and encapsulated into hard gelatin capsules, then drug release was studied USP basket method at 50 rpm and controlling the temperature 370C. Ibuprofen is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain and stiffness. An attempt was taken to study the effect of surfactants and carriers in badly water soluble drug (Ibuprofen) by using solid solution method. In this trial Sodium Lauryl Sulfate, Poloxamer, Polyethylene Glycol (PEG)-6000, Tween 80 and Polyvinylpyrrolidone (PVP) K30 were used as solubilising agent. Ibuprofen is badly water soluble drug and distilled water was used...
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Posted by admin on Apr 1, 2013 in |
Exercising in a gym, largely aimed at getting a better-shaped body, is a long and tiring process. So many people opt for power enhancing drugs, boosting their athletic performance. These include steroids, erythropoietin, creatine, protein and zinc supplements among others. Together with increasing the muscle bulk, they exert highly undesirable effects on normal physiology. The subjects were asked to fill in a detailed proforma, which aimed at evaluating the effects of PEDs and exercise on aggression, frustration, irritation, anger, mood changes, behavioral changes etc. The results were compared against a control group that comprised of individuals who were working out without using PED. The results suggested that through an unknown mechanism PED usage has affected various psychological parameters of the...
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