Posted by admin on Jun 1, 2013 in |
Background: Most recently fertility issues in HIV positive men and women are becoming increasingly important. Because of ART access and its good life effect, it is expected that the need and desire to get married, to have children and to have sexual partners for PLWHA would change with the regard to reproductive health. In Ethiopia HIV positive individuals may or may not have desire to have children. And the extent of this desire and how it varies by individual, health and demographic characteristics is not well known. Objective: the aim of the study was to assess desire for fertility and associated factors among PLWHA in selected ART clinics of Horro Guduru Wollega Zone, Oromia National Regional State, Ethiopia Methods: A cross-sectional, institutional-based study that employed quantitative and qualitative in-depth interviews was conducted. Three hundred twenty one study subjects were selected using systematic random sampling technique and the data was collected using interviewer administered structured questionnaire. Data entry and analysis were performed using EPI Info version 3.5.1 and SPSS version...
Read More
Posted by admin on Jun 1, 2013 in |
The quest for eternal health has made mankind to intensively research the nature itself. Nature has a rich source of medicinal plants, the proper use of which is necessary to maintain health. According to WHO, almost 80% of the population of developing countries has utmost faith in traditional medicines, of which plants are the important source. WHO recommends macroscopic and microscopic studies of the herb should be the first step in authentication, which is necessary to ensure the quality of any medicinal product. Cyperus rotundus (L.), a medicinal plant belonging to the family of the Cyperaceae, grows all over India. In the present study macroscopic and microscopic characterization of the rhizomes of Mustawas done to develop an atlas of diagnostic characters by the standard methodology of macro-microscopic characterization of herbal raw drugs. Macroscopical and organoleptic characters as well as the microscopic features of Musta rhizomes were documented. A self-explanatory atlas of photomicrographs was prepared to aid rapid identification of raw drug called Musta. The atlas will serve as standard...
Read More
Posted by admin on Jun 1, 2013 in |
The present study was undertaken to investigate the hepatotoxic potential of rosiglitazone- an oral hypoglycemic thiazolidenedione class of drug. The hepatotoxic potential of rosiglitazone was assessed in-vitro on isolated rat hepatocytes before subjecting to in-vivo studies. The in-vitro activity was measured by trypan blue exclusion assay and determination of liver marker enzymes. The hepatotoxic potential of rosiglitazone was measured at 100 to 500 µg/ml concentration and maximum hepatotoxicity was produced at highest concentration tested. In-vivo hepatotoxic potential of rosiglitazone was assessed on hyperglycemic rats and protective effect of silymarin a known hepatoprotective agent was also tested. When rosiglitazone was administered at the dose of 2 mg/kg body weight for 21 successive days on rats, has produced marked hepatotoxicity when compared to normal animals. The hepatotoxic potential was evaluated by determination of serum biochemical markers and liver anti-oxidant enzyme studies. Hypoglycemic effect of rosiglitazone in presence of silymarin was also assessed in alloxan induced hyperglycemic rats to rule out any drug interaction. The rosiglitazone has produced significant elevation of serum...
Read More
Posted by admin on Jun 1, 2013 in |
Solid lipid nanoparticle proved appropriate as prolonged release formulation for lipophilic drugs. The present work dealt with the preparation of the antifungal lipophilic drug nystatin into solid lipid nanoparticles ((Nyst-SLNs).) formulation for topical delivery with the aim to prolong its release and effectiveness. Hot homogenization and ultrasonication were applied in the production of (Nyst-SLNs). Different matrix material and stabilizers were tested. All the formulations were subjected to particle size analysis, zeta potential, drug entrapment efficiency and in-vitro release studies. Transmission electron microscopy was conducted to investigate the morphology of nystatin loaded nanoparticles. The differential scanning calorimetry visualized the dispersed amorphous state of nystatin in the SLN. In addition, the present study addresses the compositions of different formulation on the physicochemical properties and drug release profile of...
Read More
Posted by admin on Jun 1, 2013 in |
In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot plate method using Morphine Sulfate as a standard reference drug. Anti-inflammatory activity was evaluated by mercury displacement method using Diclofenac as standard reference drug. The results were expressed as mean ± S.E.M. The data were statistically analyzed by Student’s t test and P<0.05 were considered as significant. The screening data shows that synthesized compounds possess potential analgesic and anti-inflammatory...
Read More
