Posted by admin on Apr 1, 2013 in |
The concerned study reveals the first time experimental investigation of Hypoglycemic and antihyperglycemic effect of seed extract of Acacia tortilis plant was in normoglycaemic and Alloxan-induced (135 mg/Kg body weight intraperitoneally) diabetic rats. The seed extract at the dose of 100 and 200 mg/kg body weight was administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) and blood glucose estimation was done in all groups. The extract significantly lowered the blood glucose levels to an extent comparable to that produced by standard Oral hypoglycemic drug (Gliclazide 22 mg/Kg body weight) in both normal and diabetic rats. The results suggest that seed extract of Acacia tortilis possess significant antidiabetic activity. The extract seems promising for the development of a phytomedicine for diabetes mellitus in future...
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Posted by admin on Apr 1, 2013 in |
In this study, five different products of each metronidazole tablets and benzoate salt oral suspensions were purchased from the different retail outlets in the local market of Addis Ababa and analyzed using official methods (Pharmacopoeial methods of USP/BP/IP) by employing HPLC for the tablet dosage forms and non-aqueous titration with potentiometric end point for the suspensions. The assay results showed that all brand and generic products of metronidazole tablets and metronidazole benzoate oral suspensions met the USP and the IP specifications, respectively. Furthermore, all the tablets analyzed have passed the hardness, friability and weight variation tests. All tablets except metrogyl passed the disintegration time test and dissolution rate test specifications of BP/USP. In addition, different brands and a generic product of metronidazole benzoate oral suspensions were evaluated by determining their physical stability with respect to the two useful parameters, sedimentation volume and Viscosity. Amrizole has relatively moderate viscosity (728.0 ± 0.12 cP), which may cause good pourability of the suspension with a sedimentation value of 1 (acceptable and stable...
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Posted by admin on Apr 1, 2013 in |
The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant free radical scavenging activity with IC50 value of 119.0µg/ml for S. japonica stem. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The LC50 value of sample CTJS (Carbon Tetrachloride fraction of S. japonica Stem), was 3.0µg/ml is highly most significant. Antibacterial activity was tested by disk diffusion method. The Carbon Tetrachloride soluble fraction showed good antibacterial activity against different species of bacteria at different doses. The Ethyl Acetate soluble fraction shows good activity only against E. coli at different...
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Posted by admin on Apr 1, 2013 in |
Adenia lobata Engl (Passifloraceae) is a woody climber which grows in most African countries mainly the coastal belt. It is an important medicinal plant used to treat haemorrhoids, malaria, fever, diabetes and gonorrhea. In our attempt to find out the constituents of this medicinal plant, the dried stem powder of A. lobata was successively extracted by Soxhlet with petroleum ether and 70% ethanol to obtain the crude petroleum ether (PEAL: yield =1.1w/w %) and ethanol (EEAL: yield = 5.4 w/w %) extracts. The antihyperglycaemic activity of PEAL and EEAL were determined in streptozotocin-induced diabetic rats (70 mg/kg body weight). The ethanol extract was most active and was subjected to chromatographic separation to isolate its chemical constituents. The isolated compounds were identified using NMR spectroscopic namely 1H, 13C NMR, COSY, HSQC and HMBC Spectroscopy with reference to literature. Two compounds isolated from the extract were found to be, palmitic acid and g-hydroxy-d-valerolactone. To the best of our knowledge, this is the first time these compounds are reported from this medicinal...
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Posted by admin on Apr 1, 2013 in |
Objective: The study was designed to evaluate the efficiency of pharmaceutical care on the control of clinical parameters, such as fasting glycaemia and glycosylated haemoglobin also to assess drug therapy problems in patients with type 2 diabetes mellitus. Setting: the study was conducted at Diabetic Center in Sulaimany/Iraq, during 18 September 2010 -20 January 2011. Methods: A prospective and randomized control trial study was conducted with 130 type 2 diabetes patients with glycosylated haemoglobin of higher than 7.0%, they were divided into two groups: (i) pharmaceutical care (intervention) group (n=65), and (ii) the control group (n=65). They were monitored for 3 consecutive visits. Patients in the control group received usual medical care, but patients in the intervention group received both standard medical care and pharmaceutical care. Results: At the end of the study, a statistically significant reduction was observed in the glycemic levels of patients in the intervention group whilst a small reduction, which is statistically not significant, was detected in the control group. Furthermore, the follow-up of the...
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