Posted by admin on Mar 1, 2013 in |
The antioxidant activities of five wild leafy vegetables e.g. Allium porrum, Carpesium cernuum, Tricyrtis pilosa, Spilanthes acmella, and Leea sambucina collected from Meghalaya state in India were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power ability, estimation of total phenolic content, flavonoid content and flavonol content.. The results indicate that these wild edible plants can be utilized as natural antioxidant. The solvent systems used were benzene, chloroform, acetone and methanol. The different levels of antioxidant activities were found in the solvent systems used. The results indicate that these wild edible vegetables can be utilized as natural...
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Posted by admin on Mar 1, 2013 in |
The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in 500 ml phosphate buffer (pH 6.5) for 8 hours. The release mechanism was explored with zero order, first order, Higuchi equation and Korsmeyer’s equation. The drug release followed Higuchi equation. It was found that the release of drug from matrix tablet decrease with the increasing of percentage of polymer. The two high viscosity polymers (Methocel K4MCR and Methocel K100MCR) were found suitable for the...
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Posted by admin on Mar 1, 2013 in |
Background: Death related to unintended pregnancy associated events is a series public health concern in Ethiopia. This is very common in young adolescents for whom life is full of adventure and temptation with very little knowledge about the consequences of their reckless activities. Emergency contraceptives are the only method that can be used within short time after sexual intercourse, offering a second chance to prevent unwanted pregnancy. Objectives: To assess the knowledge, attitude and practice of emergency contraceptives among female college students at Mekelle town, Ethiopia. Methods: An institutional based cross-sectional survey was conducted among 616 female college students at Mekelle town from March to July, 2011. Multistage sampling technique with Probabilities proportional to size was used. Data were analyzed by SPSS window version 16.0 software package and presented using frequencies, percentages. Crude & adjusted odds ratio were used to control the possible confounding variables. Results: Of the total respondents, 393(67.3%) of them replied that they have heard about emergency contraceptives. Among those who have ever heard of emergency...
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Posted by admin on Mar 1, 2013 in |
The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – high performance liquid chromatography (RP-HPLC) method. In single and multiple dose study, verapamil significantly increased the pioglitazone exposure (AUC, Cmax) and decreased its elimination by prolongation of t1/2 and mean residence time (MRT) with a relative decrease in clearance (CL). The effect is more significant in diabetic rats. In the present study a pharmacokinetic interaction between verapamil and pioglitazone was observed. The possible interaction may involve both P-glycoprotein and CYP enzymes. Investigating this type of interactions pre-clinically is helpful to avoid drug-drug interactions in actual clinical...
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Posted by admin on Mar 1, 2013 in |
Protein drug delivery has emerged to be an important area of research in the field of novel drug delivery technology. The objective of the study was to prepare poly (D, L-lactide-co-glycolide) (PLGA) microspheres containing bovine serum albumin (BSA) as a model drug and to evaluate the various physicochemical characteristics of the formulations, namely morphology, particle size, FTIR, DSC, BSA encapsulation efficiency and in-vitro BSA release profile. BSA-loaded microspheres were prepared by double emulsion solvent evaporation method with different BSA: PLGA ratios and at different speeds of homogenization keeping the amount of BSA constant in all the formulations. Out of those 1:10 was selected as a optimized (drug: polymer) for BSA loaded PLGA microspheres, there after internal parameters like volume of inner aqueous phase(2ml), volume of DCM(10ml), concentration of polymer (9.09%),speed of homogenization, were selected as a optimized formulation parameters. Accelerated stability testing was performed with the optimized formulations for a period of eight weeks. The mean particle size and encapsulation efficiency of the microspheres were found to decrease as ...
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