Posted by admin on Apr 1, 2013 in |
Purpose: The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. Methods: Histopathological alterations in the developing ovaries were examined in neonates from birth to 21st day of weaning on specific days viz. 1, 7, 14 and 21st day of postnatal development. Lead acetate was administered via oral gavaging at 266 mg/kg/bodyweight and 1066 mg/kg/bodyweight to pregnant Swiss mice from 10th day of gestation to 21st day of lactation. Results: Studies conducted on females revealed mostly miscarriages, premature delivery and infant mortality. Lead suppresses the development of various follicles during fetal and neonatal life. Conclusion: It appears that lead interferes during specific events of ovarian developmental stages, which may create higher sensitivity for dysfunction in reproductive system during adulthood. The present investigation evaluates the relative...
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Posted by admin on Apr 1, 2013 in |
Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipients (surfactants and carriers) was heated first and then hardened by cooling to room temperatures. They were then pulverized, sieved, and encapsulated into hard gelatin capsules, then drug release was studied USP basket method at 50 rpm and controlling the temperature 370C. Ibuprofen is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain and stiffness. An attempt was taken to study the effect of surfactants and carriers in badly water soluble drug (Ibuprofen) by using solid solution method. In this trial Sodium Lauryl Sulfate, Poloxamer, Polyethylene Glycol (PEG)-6000, Tween 80 and Polyvinylpyrrolidone (PVP) K30 were used as solubilising agent. Ibuprofen is badly water soluble drug and distilled water was used...
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Posted by admin on Apr 1, 2013 in |
Exercising in a gym, largely aimed at getting a better-shaped body, is a long and tiring process. So many people opt for power enhancing drugs, boosting their athletic performance. These include steroids, erythropoietin, creatine, protein and zinc supplements among others. Together with increasing the muscle bulk, they exert highly undesirable effects on normal physiology. The subjects were asked to fill in a detailed proforma, which aimed at evaluating the effects of PEDs and exercise on aggression, frustration, irritation, anger, mood changes, behavioral changes etc. The results were compared against a control group that comprised of individuals who were working out without using PED. The results suggested that through an unknown mechanism PED usage has affected various psychological parameters of the...
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Posted by admin on Apr 1, 2013 in |
Vasectomy is one of the most effective but less utilized types of contraception method which could addresses the involvement of males to the family planning. The aim of the study was therefore to investigate the awareness about and practice of men towards vasectomy among workers in Dashen brewery, Ethiopia. Descriptive cross sectional study was conducted using pre tested self-administered questioner to assess the Knowledge, attitude and factors associated with low utilization of vasectomy. A total of 187 study participants were included to this study using single population proportion formula and random sampling technique. Majority of the participants 155 (82.9%) never heard about vasectomy as a contraception method. Their knowledge about vasectomy is generally very poor as large proportion of respondents didn’t know how it works, its effectiveness and its effect on their sexual performance. None of the respondents have ever used vasectomy as a modern male contraception method. Misleading information towards its impact on sexual performance/desire was reported as a main reason not to use this method. Among others...
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Posted by admin on Apr 1, 2013 in |
Interest in medicinal plant as a re-emerging health aid has been fuelled by the rising cost of prescription drug in the maintenance of personal health. In present work an attempt has been made to carry out antimicrobial activity of bryonia laciniosa plant, used in Indian folk medicine. The aim of the study was to grow in vitro callus from bryonia laciniosa from leaf explants and its microbial activity. Antibacterial effect of Bryonia laciniosa was evaluated on bacterial strains like Bacillus cereus, Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli and Klebsiella pneumoniae. The solvents used for the extraction of plants were water and methanol. The in vitro antibacterial activity was performed by agar disc diffusion. The most susceptible bacteria was K. pneumoniae. The extracts of callus and plant material could not inhibit any of the bacterial strains investigated. Callus was induced from leaf explants in Murashige and Skoog (MS) medium supplemented with different combinations of auxin and cytokinin growth regulators. The Callus was induced in MS medium with 2, 4-D (3mg/l)...
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