Posted by admin on Jan 1, 2013 in |
Viruses are the major pathogenic agents that can cause variety of diseases in humans, animals and plants. Several deadly diseases like Hepatitis A, Hepatitis C, encephalitis, meningitis, and influenza are caused by viruses. Due to the constant and rapid emergence of viral pathogens, current recommended commercial drugs for above diseases are becoming resistant. In this view in present study forty three medicinal plants with numerous phytochemicals present in Dukes phytochemical database are subjected to PASS (Prediction of Activity Spectra for Substances) server for the prediction of their biological activity. Compounds with maximum probable activity for inhibiting specific viral targets are chosen and their drug likeliness is estimated based on Lipinski’s rule of five. The medicinal value of those compounds and its activity for inhibiting specific viral targets are analyzed from the PASS prediction results. Several interesting properties of Influenza virus, Arbovirus, Picornavirus, Flavivirus, and Herpes virus proteases with catalytic dyad and triad, active site, three dimensional structural features and their role in disease progression are review from the literature. ...
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Posted by admin on Jan 1, 2013 in |
Background: Oxystelma esculentum is used traditionally as diuretic, laxative, hepatoprotective and anti-ulcer. Objectives: The present work deals with the isolation and structure elucidation of Epicatechin from O. esculentum. Methods: Methanolic extract of the entire plant of O. esculentum was subjected to pilot TLC experiments and column chromatography. Results: This yielded a pure, white compound which resolved at Rf 0.3 on TLC plate using the mobile phase toluene: ethyl acetate (5:4) when developed in iodine chamber. This compound was subjected to UV, IR and 1H-NMR spectral analysis and its structure elucidation revealed it to be Epicatechin. Conclusion: This compound has been reported for the first time in this plant and can serve as a useful tool in its...
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Posted by admin on Jan 1, 2013 in |
Introduction: Solanum nigrum (S. nigrum) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of S. nigrum against experimentally induced hepatotoxicity in albino rats. Aim of the study: To explore the hepatoprotective activity of S. nigrum. Materials and Methods: Albino Wistar rats weighing 150-200g of either sex were divided into six groups of six animals each. Group I was given normal saline (PO), group II Carbon tetrachloride (CCl4) (IP), group III Liv. 52 syrup for twenty days followed by carbon tetrachloride, group IV, V & VI received aqueous extract of Solanum nigrum ( 2ml/100g/day twice daily) orally for 10, 20 & 30 days respectively followed by CCl4. Blood was collected from anaesthetized animals & liver was dissected out. Alanine transaminase (ALT), alkaline phosphatase (ALP) & Total bilirubin were estimated and liver was subjected to histopathological examination. Results: ALT, ALP & Total bilirubin levels were significantly increased in CCl4 treated group...
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Posted by admin on Jan 1, 2013 in |
The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 to 8.1 mM ±SEM) i.e., 68.44% in 300mg/kg ethyl acetate extract as a 7 days hypoglycemic treatment. On 120 minutes OGTT test, reduction of blood glucose level was also significant. In 300mg/kg extract blood glucose level reduced from (20.53mM to 7.69 ±SEM) 62.64% was observed. Analgesic treatment was observed carefully and mentionable activities were evaluated. Percentage of inhibition was 58.16 with the number of writhing 11.8±SEM in 300mg/kg inhibition was observed with 6.8 ±SEM writhing. P. pellucida has significant anti-inflammatory effect after 4 hr with 3.47± SEM. The present study indicates significant hypoglycemic, analgesic and anti-inflammatory effects of P. pellucida. The present investigation established the pharmacological evidence to support the folklore claim and that of...
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Posted by admin on Jan 1, 2013 in |
In the present research work, diethyl malonate and phenyl hydrazine were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro-butyl and 4-nitrooxy-butyl substitution at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal...
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