Posted by admin on May 1, 2013 in |
In the present study an attempt has been made to prepare fast dissolving tablets of Sumatriptan Succinate to improve dissolution rate of the drug in oral cavity & hence better patient’s compliance & effective therapy. Sumatriptan Succinate is a 5-HT1D (5-hydroxy tryptamine 1D) receptor agonist, used in the treatment of migraine and cluster headache. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate fast dissolving tablets of Sumatriptan succinate to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving Sumatriptan succinate was prepared using superdisintegrants Crospovidone, Croscarmellose Sodium, and Preglatinised Starch using the direct compression method. The tablets prepared were evaluated for Thickness, Uniformity of weight, Drug content, Hardness, Friability, Wetting time, in vitro and in vivo disintegration time, in vitro drug release. The formulation F3 containing Crospovidone (8%) was found to give the best result since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient...
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Posted by admin on May 1, 2013 in |
Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. Objective: To assess the pattern of drug use among pregnant women in Adama Referral Hospital, Oromia region, Ethiopia. Methods: All drug prescriptions of pregnant women prescribed from December 1, 2011 to May 30 2011 were reviewed retrospectively using structured data collection format. Result: A total of 381 pregnant women prescriptions were included in the study. The average maternal age in the study was 26.74 years. A total of 176(24.44%), 336(46.66%) and 208(28.88%) drugs with an average 2.2, 1.13 and 1.83 per pregnant women were used in first, second and third trimesters respectively. Minerals and vitamins 209(29%) were the most frequently prescribed drugs followed by Antibiotics...
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Posted by admin on May 1, 2013 in |
Two simple, precise and accurate methods were developed and validated for the Simultaneous estimation of Hydrocortisone acetate and Sulphacetamide sodium in the combined dosage forms. The first method involves the usage of Simultaneous equation for the determination and the second method employed is the Multicomponent mode. For both the methods the wavelengths selected were 241.5nm and 271.0nm which are the absorbance maxima of Hydrocortisone acetate and Sulphacetamide sodium respectively. The drugs obeyed Beer’s law in the concentration range of 5-50µg/mL for hydrocortisone acetate and 5-40 µg/mL for Sulphacetamide sodium. The results of the analysis were validated statistically and by recovery...
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Posted by admin on May 1, 2013 in |
The study aims at assessing Basil’s genetic phenotypic variability and viral disease incidence in India for sustainable pathological interventions. Basil (Ocimum basilicum) is important for its medicinal and nutritive value. It is highly adaptable as a potential crop in the tropics and could therefore enhance the food security of India nations. Germplasm seed evaluation and characterization was therefore carried out from the Research lab, D.B.S. College (R.L.D.B.S.C.) & F.F.D.C. seed collection survey to expand F.F.D.C. basil genetic base. The field layout was completely randomized design with five replications. The treatments were: O. basilicum, O. gratissimum and the local basil. Treatments were randomly allocated per replication. There were significant phenotypic differences in the O. basilicum variety. These differences were observed in the plant coloration ranging from deep to light purple coloration of stem, leaf, leaf vein and petiole. Our observations also revealed for the first time significant tolerance to Venial Mottle Mosaic Virus (VMMV) in the purple colored compared to the green O. basilicum in the early stages of growth...
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Posted by admin on May 1, 2013 in |
: The aim of the present study is to evaluate the cytotoxic effect of the ink extracts of different specis of cuttlefish (Sepia pharaonis female, Sepia pharaonis male, Sepiella inermis female, Sepia aculeata female) and squid (Loligo duvauceli female). The ink extracts were prepared by delipidation with acetone and extracted by Tris HCl buffer. The cytotoxic effect of the drug was studied using Trypan blue cell viability assay andethidium bromide /acridine orangestaining. The ink extracts from different species of squid and cuttlefish inhibited cell proliferation and induced cell death in a dose dependent manner. The cytotoxic effects induced by cuttlefish ink extract on chick embryo fibroblast cells involve typical apoptotic changes like nuclear condensation, studied using ethidium bromide and acridine orange staining. The ink extracts from the female Cuttlefish, Sepia pharaonis (25 and 75 µg/ml) showed the highest antiproliferative activity. The results suggested the potent antiproliferative effect of the ink of cuttlefish, Sepia pharaonis on chicken embryo fibroblasts and thereby the therapeutic potential of the ink as an anticancer...
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